Involvement of basal ganglia transmitter systems in movement initiation

Hauber, Wolfgang

doi:10.1016/s0301-0082(98)00041-0

Cited by 206 publications

(126 citation statements)

References 323 publications

Supporting

Mentioning

102

Contrasting

Unclassified

Order By: Relevance

“…Neurons expressing D 1 receptors form the direct pathway, which projects to internal globus pallidus and substantia nigra, while neurons expressing D 2 receptors make up the indirect pathway, projecting to external globus pallidus (McKenzie et al, 1984;Paul et al, 1992;O'Connor, 1998;Nicola et al, 2000;Svenningsson et al, 2000;Onn et al, 2000). Dopamine is a relevant modulator of striatal excitatory inputs from the cortex, generally facilitating motor behavior (initiation, sequencing, and ending of movement, Hauber, 1998). In addition, there are several behaviors that can be elicited by specific stimulation of either dopamine D 1 or D 2 receptors.…”

Section: Discussionmentioning

confidence: 99%

Expression and Function of CB1 Receptor in the Rat Striatum: Localization and Effects on D1 and D2 Dopamine Receptor-Mediated Motor Behaviors

Martín

Fernández-Espejo

Ferrer

et al. 2007

Neuropsychopharmacol

136

View full text Add to dashboard Cite

Cannabinoid CB 1 receptors are densely expressed on striatal projection neurons expressing dopamine D 1 or D 2 receptors. However, the specific neuronal distribution of CB 1 receptors within the striatum is not known. Previous research has established that the endocannabinoid system controls facilitation of behavior by dopamine D 2 receptors, but it is not clear if endocannabinoids also modulate D 1 receptor-mediated motor behavior. In the present study, we show that cannabinoid CB 1 receptor mRNA is present in striatonigral neurons expressing substance P and dopamine D 1 receptors, as well as in striatopallidal neurons expressing enkephalin and dopamine D 2 receptors. We explored the functional relevance of the interaction between dopamine D 1 and D 2 receptors and cannabinoid CB 1 receptors with behavioral pharmacology experiments. Potentiation of endogenous cannabinoid signaling by the uptake blocker AM404 blocked dopamine D 1 receptor-mediated grooming and D 2 receptor-mediated oral stereotypies. In addition, contralateral turning induced by unilateral intrastriatal infusion of D 1 receptor agonists is counteracted by AM404 and potentiated by the cannabinoid antagonist SR141716A. These results indicate that the endocannabinoid system negatively modulates D 1 receptor-mediated behaviors in addition to its previously described effect on dopamine D 2 receptor-mediated behaviors. The effect of AM404 on grooming behavior was absent in dopamine D 1 receptor knockout mice, demonstrating its dependence on D 1 receptors. This study indicates that the endocannabinoid system is a relevant negative modulator of both dopamine D 1 and D 2 receptor-mediated behaviors, a finding that may contribute to our understanding of basal ganglia motor disorders.

show abstract

Section: Discussionmentioning

confidence: 99%

Expression and Function of CB1 Receptor in the Rat Striatum: Localization and Effects on D1 and D2 Dopamine Receptor-Mediated Motor Behaviors

Martín

Fernández-Espejo

Ferrer

et al. 2007

Neuropsychopharmacol

136

View full text Add to dashboard Cite

show abstract

“…[54,58]). This may indicate that multiple neurotransmitter systems are involved, just as they are in drug-induced stereotypy (for review see: [9,25,28,65]), or that, rather than the transmitter levels and receptor densities most commonly measured (e.g. [54,58]), subtle aspects of the systems are implicated such as receptor sensitivity (e.g.…”

Section: Introductionmentioning

confidence: 99%

Evidence for a relationship between cage stereotypies and behavioural disinhibition in laboratory rodents

Garner

Mason

2002

Behavioural Brain Research

217

163

View full text Add to dashboard Cite

Cage stereotypies */abnormal, repetitive, unvarying and apparently functionless behaviours */are common in many captive animals, sometimes resulting in self-injury or decreased reproductive success. However, a general mechanistic or neurophysiological understanding of cage stereotypies has proved elusive. In contrast, stereotypies in human mental disorder, or those induced by drugs or brain lesions, are well understood, and are thought to result from the disinhibition of behavioural selection by the basal ganglia. In this study, we found that the cage stereotypies of captive bank voles also correlate with signs of altered response selection by the basal ganglia. Stereotypic bar-mouthing in the caged voles correlated with inappropriate responding in extinction learning, impairments of response timing, evidence of a knowledge-action dissociation, increased rates of behavioural activation, and hyperactivity. Furthermore, all these signs intercorrelated, implicating a single underlying deficit consistent with striatal disinhibition of response selection. Bar-mouthing thus appears fundamentally similar to the stereotypies of autists, schizophrenics, and subjects treated with amphetamine or basal ganglial lesions. These results represent the first evidence for a neural substrate of cage stereotypy. They also suggest that stereotypic animals may experience novel forms of psychological distress, and that stereotypy might well represent a potential confound in many behavioural experiments. #

show abstract

“…2). The overall function of these loops is to facilitate the initiation and execution of movement (Hauber 1998), the selection of purposeful patterns of movement in response to internal and environmental stimuli (Pessiglione et al 2003), and reward and motivation (Pessiglione et al 2006). …”

mentioning

confidence: 99%

Double-dissociation between the mechanism leading to impulsivity and inattention in Attention Deficit Hyperactivity Disorder: A resting-state functional connectivity study

Sanefuji

Craig

Parlatini

et al. 2017

Cortex

View full text Add to dashboard Cite

Two core symptoms characterize Attention Deficit Hyperactivity Disorder (ADHD) subtypes: inattentiveness and hyperactivity-impulsivity. While previous brain imaging research investigated ADHD as if it was a homogenous condition, its two core symptoms may originate from different brain mechanisms. We, therefore, hypothesized that the functional connectivity of cortico-striatal and attentional networks would be different between ADHD subtypes. We studied 165 children (mean age 10.93 years; age range, 7-17 year old) diagnosed as having ADHD based on their revised Conner's rating scale score and 170 typical developing individuals (mean age 11.46 years; age range, 7-17 year old) using resting state functional fMRI. Groups were matched for age, IQ and head motion during the MRI acquisition. We fractionated the ADHD group into predominantly inattentive, hyperactive-impulsive and combined subtypes based on their revised Conner's rating scale score. We then analyzed differences in resting state functional connectivity of the cortico-striatal and attentional networks between these subtypes. We found a double dissociation of functional connectivity in the cortico-striatal and ventral attentional networks, reflecting the subtypes of the ADHD participants. Particularly, the hyperactive-impulsive subtype was associated with increased connectivity in cortico-striatal network, whereas the inattentive subtype was associated with increased connectivity in the right ventral attention network. Our study demonstrated for the first time a right lateralized, double dissociation between specific networks associated with hyperactivity-impulsivity and inattentiveness in ADHD children, providing a biological M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT 2 basis for exploring symptom dimensions and revealing potential targets for more personalized treatments.

show abstract

Involvement of basal ganglia transmitter systems in movement initiation

Cited by 206 publications

References 323 publications

Expression and Function of CB1 Receptor in the Rat Striatum: Localization and Effects on D1 and D2 Dopamine Receptor-Mediated Motor Behaviors

Expression and Function of CB1 Receptor in the Rat Striatum: Localization and Effects on D1 and D2 Dopamine Receptor-Mediated Motor Behaviors

Evidence for a relationship between cage stereotypies and behavioural disinhibition in laboratory rodents

Double-dissociation between the mechanism leading to impulsivity and inattention in Attention Deficit Hyperactivity Disorder: A resting-state functional connectivity study

Contact Info

Product

Resources

About