Involvement of adenylate cyclase/cAMP/CREB and SOX9/MITF in melanogenesis to prevent vitiligo

Arora, Navneet; Siddiqui, Ehraz Mehmood; Mehan, Sidharth

doi:10.1007/s11010-020-04000-5

Cited by 19 publications

(17 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…α-MSH, which is a hormone that is involved in the first stage of melanogenesis, stimulates phosphorylation of protein kinase A (PKA) and cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB) in melanocytes, thus inducing the synthesis of the downregulating proteins that are associated with melanogenesis [ 31 , 32 , 33 , 34 ]. Therefore, we next examined whether imperatorin induces melanogenesis via the PKA/CREB signaling pathway in B16F10 cells.…”

Section: Resultsmentioning

confidence: 99%

“…Thus, natural products that target the cAMP/PKA/CREB axis act as potent regulators of melanogenesis. In addition, CREB increases melanogenesis by activating MITF expression, which promotes the transcription of TYR, TYRP-1, and TYRP-2 [ 31 , 32 , 33 , 34 ]. Chen et al [ 46 ] previously reported that knockout of the MITF-M gene caused albinism in mice, which confirmed the importance of MITF as a key transcription factor in melanin production.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Imperatorin Positively Regulates Melanogenesis through Signaling Pathways Involving PKA/CREB, ERK, AKT, and GSK3β/β-Catenin

Kim

Hyun

2022

Molecules

View full text Add to dashboard Cite

The present study investigated the melanogenic effects of imperatorin and isoimperatorin and the underlying mechanisms of imperatorin using a mouse melanoma B16F10 model. Interestingly, treatment with 25 μM of either imperatorin or isoimperatorin, despite their structural differences, did not produce differences in melanin content and intracellular tyrosinase activity. Imperatorin also activated the expression of melanogenic enzymes, such as tyrosinase (TYR) and tyrosinase-related proteins TYRP-1 and TYRP-2. Mechanistically, imperatorin increases melanin synthesis through the cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA)/cAMP-responsive element-binding protein (CREB)-dependent upregulation of microphthalmia-associated transcription factor (MITF), which is a key transcription factor in melanogenesis. Furthermore, imperatorin exerted melanogenic effects by downregulating extracellular signal-regulated kinase (ERK) and upregulating phosphatidylinositol 3 kinase (PI3K)/protein kinase B (AKT)/glycogen synthesis kinase-3β (GSK-3β). Moreover, imperatorin increased the content of β-catenin in the cell cytoplasm and nucleus by reducing the content of phosphorylated β-catenin (p-β-catenin). Finally, we tested the potential of imperatorin in topical application through primary human skin irritation tests. These tests were performed on the normal skin (upper back) of 31 volunteers to determine whether 25 or 50 µM of imperatorin had irritation or sensitization potential. During these tests, imperatorin did not induce any adverse reactions. Taken together, these findings suggest that the regulation of melanogenesis by imperatorin can be mediated by signaling pathways involving PKA/CREB, ERK, AKT, and GSK3β/β-catenin and that imperatorin could prevent the pathogenesis of pigmentation diseases when used as a topical agent.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Imperatorin Positively Regulates Melanogenesis through Signaling Pathways Involving PKA/CREB, ERK, AKT, and GSK3β/β-Catenin

Kim

Hyun

2022

Molecules

View full text Add to dashboard Cite

show abstract

“…Potential candidate genes observed within selection signals on chromosome 2 (WNT4, FZD7, FZD5) are implicated in Wnt signaling [66,67], which is an essential process for melanogenesis [68]. Likewise, the CREB1 gene located within selection signatures on chromosome 2 is involved in the melanin production process by transcriptional activation of the microphthalmia-associated transcription factor (MITF) gene [69]. As possible candidate genes in the region of selection signals on chromosome 13, we observed the GNAS and GNAS-AS1 genes, which are involved in the production and regulation, respectively, of G proteins such as the G protein α-subunit (Gs), functioning in melanogenesis as well [70][71][72].…”

Section: Discussionmentioning

confidence: 99%

Capturing Genetic Diversity and Selection Signatures of the Endangered Kosovar Balusha Sheep Breed

Adeniyi

Simon

Bytyqi

et al. 2022

Genes

View full text Add to dashboard Cite

There is a growing concern about the loss of animal genetic resources. The aim of this study was to analyze the genetic diversity and potential peculiarity of the endangered Kosovar sheep breed Balusha. For this purpose, a dataset consisting of medium-density SNP chip genotypes (39,879 SNPs) from 45 Balusha sheep was generated and compared with SNP chip genotypes from 29 individuals of a second Kosovar breed, Bardhoka. Publicly available SNP genotypes from 39 individuals of the relatively closely located sheep breeds Istrian Pramenka and Ruda were additionally included in the analyses. Analysis of heterozygosity, allelic richness and effective population size was used to assess the genetic diversity. Inbreeding was evaluated using two different methods (FIS, FROH). The standardized FST (di) and cross-population extended haplotype homozygosity (XPEHH) methods were used to detect signatures of selection. We observed the lowest heterozygosity (HO = 0.351) and effective population size (Ne5 = 25, Ne50 = 228) for the Balusha breed. The mean allelic richness levels (1.780–1.876) across all analyzed breeds were similar and also comparable with those in worldwide breeds. FROH estimates (0.023–0.077) were highest for the Balusha population, although evidence of decreased inbreeding was observed in FIS results for the Balusha breed. Two Gene Ontology (GO) TERMs were strongly enriched for Balusha, and involved genes belonging to the melanogenesis and T cell receptor signaling pathways, respectively. This could result from selection for the special coat color pattern of Balusha (black head) and resistance to certain infectious diseases. The analyzed diversity parameters highlight the urgency to preserve the local Kosovar Balusha sheep as it is clearly distinguished from other sheep of Southeastern Europe, has the lowest diversity level and may harbor valuable genetic variants, e.g., for resistance to infectious diseases.

show abstract

“…This pathway ends up in the activation of the microphthalmia-associated transcription factor (MITF). MITF orchestrates the production of pigmentation in the melanocyte by the induction of TYR, TRP-1, and TRP-2. , Additionally, the activation of MITF and the subsequent enzyme and protein overexpression can also be promoted by oxidative stress.…”

Section: Skin-related Conditionsmentioning

confidence: 99%

Potential Role of Oleanolic and Ursolic Acids from Food and Plant Materials as Natural Ingredients for the Cosmetic Industry: A Review

Mejía-Valdez

Antunes‐Ricardo

Martínez-Ávila

et al. 2023

ACS Food Sci. Technol.

View full text Add to dashboard Cite

Cosmeceuticals have emerged as health and beauty aid products that integrate active ingredients from natural sources. Phytochemicals have prevailed in this market as an effective alternative toward different skin conditions. This is mainly due to the increasing demand for natural products that overcome the side effects of conventional treatments. Alopecia, acne, and skin aging are prevalent skin-related conditions worldwide. These conditions are characterized by high levels of inflammatory biomarkers and oxidative stress conditions. Oleanolic and ursolic acids are two biologically active pentacyclic triterpenoid isomeric compounds. They have shown strong potential for the prevention and treatment of diverse skin-related conditions through their effective antioxidant and anti-inflammatory capacity. This review presents the latest available information on the biological potential of oleanolic and ursolic acids, highlighting their cosmeceutical potential. In the pursuit of a better understanding of their potential as natural ingredients of dermatological relevance, graphical analysis is provided to propose the molecular mechanisms involved in the effects of each skin-related condition.

show abstract

Involvement of adenylate cyclase/cAMP/CREB and SOX9/MITF in melanogenesis to prevent vitiligo

Cited by 19 publications

References 49 publications

Imperatorin Positively Regulates Melanogenesis through Signaling Pathways Involving PKA/CREB, ERK, AKT, and GSK3β/β-Catenin

Imperatorin Positively Regulates Melanogenesis through Signaling Pathways Involving PKA/CREB, ERK, AKT, and GSK3β/β-Catenin

Capturing Genetic Diversity and Selection Signatures of the Endangered Kosovar Balusha Sheep Breed

Potential Role of Oleanolic and Ursolic Acids from Food and Plant Materials as Natural Ingredients for the Cosmetic Industry: A Review

Contact Info

Product

Resources

About