Involution of brown adipose tissue through a Syntaxin 4 dependent pyroptosis pathway
Xiaofan Yu,
Gabrielle Benitez,
Peter Tszki Wei
et al.
Abstract:Aging, chronic high-fat diet feeding, or housing at thermoneutrality induces brown adipose tissue (BAT) involution, a process characterized by reduction of BAT mass and function with increased lipid droplet size. Single nuclei RNA sequencing of aged mice identifies a specific brown adipocyte population of Ucp1-low cells that are pyroptotic and display a reduction in the longevity gene syntaxin 4 (Stx4a). Similar to aged brown adipocytes, Ucp1-STX4KO mice display loss of brown adipose tissue mass and thermogeni… Show more
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