Investigations of Some Side-Effects Observed in Syphilitic Patients Treated With Penicillin

Kalz, Frederick

doi:10.1001/archderm.1952.01530240060008

Cited by 14 publications

(3 citation statements)

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“…There was no significant association with any systemic disease in terms of history, physical examination or laboratory investigations, and despite reports that passive transfer of dermographism is mediated by IgE (Aoyama, 1971;Newcomb & Nelson, 1973), the incidence of the atopic diathesis was not increased relative to the general population (Carr et al, 1964). Doeglas (1975) demonstrated aspirin sensitivity in 14% of twenty-two patients with symptomatic dermographism, and persistent dermographism was recorded in 10% of 100 subjects following penicillin therapy for syphilis (Kalz & Prichard, 1952). Fisher & Schwartz (i953)j however, showed no evidence of an allergic mechanism involving food or drugs in a study of twenty patients, and oral salicylates produced no change in weal size in a further ten patients (Moore-Robinson & Warin, 1967).…”

Section: Aetiology and Laboratory Investigationsmentioning

confidence: 70%

Symptomatic dermographism: Natural history, clinical features, laboratory investigations and response to therapys

et al. 1983

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Summary Fifty patients with a history of symptomatic dermographism were investigated. The mean age of onset was 25·75 years (range: ‘from birth’ to 52 years) and the peak age of onset was in the second and third decades. The mean duration at last follow‐up was 5–1 years (range: 3 months to 47 years). The duration was longer than 5 years in 22%, and longer than 10 years in 10% of the patients. Ninety‐two percent of patients, but not a single member of an age‐matched group of sixty control subjects, produced measurable wealing at a pressure of 3·5 × 105 Pa or less applied with a calibrated dermographometer. The incidence of the atopic diathesis was not increased in patients with symptomatic dermographism, and no associations with systemic diseases, food allergens or medications were established‐ Routine haematological, biochemical, microbiological and intradermal screening tests were not found to be helpful in the management of this condition. Protease inhibitor profiles revealed a significant reduction in the level of circulating a i‐antitrypsin inhibitor which was not the result of a genetic difference between the patient and control groups. In a double‐blind randomized controlled trial of eight different antihistamine regimes in twelve patients, a combination of hydroxyzine (10 mg qds) and cimetidine (400 mg qds) proved significantly superior to all other treatments in reducing dermographometer‐induced wealing, and was associated with fewest side‐effects.

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Section: Aetiology and Laboratory Investigationsmentioning

confidence: 70%

Symptomatic dermographism: Natural history, clinical features, laboratory investigations and response to therapys

et al. 1983

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“…But an indictment is not firm unless a straightforward dermatitis medicamentosa is observed-urticaria, rubelliform eruption, erythema multiforme and nodosa, multiform erythema, vasculitis and purpura, or photosensitization. The discovery of a developing or accentuated dermatographism would favor drug sensitivity (7). Elimination of all, or at least the most likely causative medication, can be tried: arsenic, phenolphthalein, antipyrene, phenobarbital, cocaine, morphine, quinine, sulfanilamide, penicillin, chloroquin, chlorthiazide and mercurials.…”

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confidence: 99%

The Diagnosis of Pruritus in the Elderly

Young

1967

J American Geriatrics Society

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“…Garai (1949) found that a patient who was sensitive to sodium and potassium penicillin was insensitive to the calcium salt, and desensitized him with gradually increasing subcutaneous doses of calcium penicillin. Kalz and Prichard (1952) published reports of cases of penicillin sensitivity that were relieved by antihistamines. Maslansky and Sanger (1952) found that penicillin is less likely to cause reactions when it is mixed with an antihistamine.…”

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confidence: 99%

Desensitization of Nurses Allergic to Penicillin

O'Driscoll¹

1955

BMJ

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CHLORPROMAZINE AND OPERATIVE STRESSBDRr ¶AL 473 Q-T interval was markedly reduced. I am indebted to Dr. Bunjd, lecturer in medicine, for reports on these.The post-operative condition of the majority of patients was satisfactory, but they tended to lie still for prolonged periods and required careful watching to ensure a clear airway. Recovery is not so rapid as after nitrous oxide and pethidine, but less sedatives are required post-operatively. SummaryChlorpromazine has been used before and during induction of anaesthesia in 150 serious-risk patients in a tropical hospital with a view to reducing the incidence of sudden alterations in blood pressure due to oversensitive autonomic reflexes occurring during major operations. It was not found possible to obtain figures which would show an obvious improvement over the standard technique using nitrous oxide and pethidine, and premedication with the opium alkaloids and scopolamine. Nevertheless, the drug is still being used, especially as a premedication before chest surgery. Overdosage is associated with hypotension and responds readily to a L-noradrenaline (levophed) infusion.

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Investigations of Some Side-Effects Observed in Syphilitic Patients Treated With Penicillin

Cited by 14 publications

References 5 publications

Symptomatic dermographism: Natural history, clinical features, laboratory investigations and response to therapys

Symptomatic dermographism: Natural history, clinical features, laboratory investigations and response to therapys

The Diagnosis of Pruritus in the Elderly

Desensitization of Nurses Allergic to Penicillin

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