Investigations of diterpene alkaloids isolated from Aconitum anthora L. and A. moldavicum L., and of aconitine-derived lipo-alkaloids

Phytochemical, pharmacological and toxicological studies of alkaloid- and sesquiterpene lactone-containing medicinal plants

“…Similarly to the traditional method, the unavoidable part of the reported process is the heating step. As the result of this method, 14-benzoyl aconitane lipo-alkaloids with various fatty acids were produced (Fig 1) [ [83][84][85]. According to the bioactivity screening of these compounds, they are inhibitors of COX-1, COX-2, 5-LOX enzymes and NaV1.2 channel.…”

“…According to the bioactivity screening of these compounds, they are inhibitors of COX-1, COX-2, 5-LOX enzymes and NaV1.2 channel. This could serve as explanation for the traditional application of aconite drugs as anti-inflammatory agents and as painkillers [85]. In vivo experiments, performed on mice, revealed that 14-Bz-aconitane lipo-alkaloids are far less toxic than aconitine (18).…”

“…Csupor (2007) [305] andBorcsa (2014) [85] provided in their PhD theses detailed review about the chemistry of Aconitum species, diterpene alkaloids and lipo-alkaloids. Therefore in this chapter the studies from 2013 have been reviewed.…”