Investigation of the topical application of procyanidin oligomers from apples to identify their potential use as a hair‐growing agent

Takahashi, Tomoya; Kamimura, Ayako; Kagoura, Masayori; Toyoda, Masahiko; Morohashi, Masaaki

doi:10.1111/j.1473-2165.2005.00199.x

Cited by 28 publications

(29 citation statements)

References 19 publications

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“…Sixteen studies met inclusion criteria ( Figure 1) [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] . A total of 1,709 male participants were included with an average age of 40 years.…”

Section: Results Of Literature Searchmentioning

confidence: 99%

Efficacy of Off-Label Topical Treatments for the Management of Androgenetic Alopecia: A Review

et al. 2019

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Androgenetic alopecia (AGA) is characterized by non-scarring follicle miniaturization. Despite the success of approved therapies, commonly reported side effects and the need for continual use has led to the investigation of alternative therapies. The aim of this paper is to critically review the success of off-label, topical monotherapies for treatment of AGA in men. A literature search was conducted to obtain randomized, controlled and blinded studies that investigated off-label, topical, monotherapies in male patients. Hair density, hair diameter and hair growth were used to evaluate treatment success. Fourteen off-label topical therapies were investigated among the 16 studies that met inclusion criteria. Nine off-label therapies were reported to produce a significantly greater improvement in hair restoration parameters (e.g., mean change from hair count and hair diameter) as compared to placebo (p<0.05 for all treatments). In two studies, procyanidin oligomers exhibited greater efficacy over vehicle with response to mean change in hair density (hairs/cm 2) (p s < 0.0001 at week 24). In conclusion, prostaglandin analogs and polyphenols, such as latanoprost and procyanidin oligomers, can improve hair restoration parameters in male AGA patients, possibly through targeting mechanisms proposed in the etiology of AGA. The current evidence suggests short term (24 weeks) use may provide benefit for hair loss patients; however, long-term efficacy and safety data are required.

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Section: Results Of Literature Searchmentioning

confidence: 99%

Efficacy of Off-Label Topical Treatments for the Management of Androgenetic Alopecia: A Review

et al. 2019

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“…Procyanidin B2 has now proven to be effective in promoting hair growth and proliferation. In murine epithelial cells, Procyanidin B2 has been shown to inhibit protein kinase C (PKC) isozymes and modulate transforming growth factors β (TGF β), a class of cytokines whose signaling pathway plays critical roles in regulating different cellular activities including cell growth, cell differentiation, and cell development [23,25,26]. To our knowledge, beyond the biological effects of procyanidins, our findings have shown for the first time an important increase in keratin biosynthesis and content in human epidermal cells, which could play an important role in the growth of skin production by favoring the keratinization process [24].…”

Section: Discussionmentioning

confidence: 99%

Induction of Hair Keratins Expression by an Annurca Apple-Based Nutraceutical Formulation in Human Follicular Cells

et al. 2019

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Hair disorders may considerably impact the social and psychological well-being of an individual. Recent advances in the understanding the biology of hair have encouraged the research and development of novel and safer natural hair growth agents. In this context, we have previously demonstrated-at both preclinical and clinical level-that an Annurca apple-based dietary supplement (AMS), acting as a nutraceutical, is endowed with an intense hair-inductive activity (trichogenicity), at once increasing hair tropism and keratin content. Herein, in the framework of preclinical investigations, new experiments in primary human models of follicular keratinocytes and dermal papilla cells have been performed to give an insight around AMS biological effects on specific hair keratins expression. As well as confirming the biocompatibility and the antioxidant proprieties of our nutraceutical formulation, we have proven an engagement of trichokeratins production underlying its biological effects on human follicular cells. Annurca apples are particularly rich in oligomeric procyanidins, natural polyphenols belonging to the broader class of bioflavonoids believed to exert many beneficial health effects. To our knowledge, none of the current available remedies for hair loss has hitherto shown to stimulate the production of hair keratins so clearly.

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“…Procyanidin B‐2 is a compound identified in apple (Malus domestica) which acts as a growth‐promoting factor on murine hair epithelial cells. Takahashi et al . describes the hair‐growing effects of 1% procyanidin B‐2 tonic after sequential use for 4 months.…”

Section: Methodsmentioning

confidence: 95%

A bibliometric study of scientific literature in Scopus on botanicals for treatment of androgenetic alopecia

Rondanelli

Perna

Peroni

et al. 2015

J of Cosmetic Dermatology

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This study has highlighted three important aspects: (1) growing interest for this topic; (2) evidences mainly in hair grow stimulants and recently in the inhibition of 5-alpha-reductase, as demonstrated by article and citation counts across years; (3) in addition, all major studies have been focused on green tea epigallocatechin-3-gallate, Serenoa repens, Citrullus colocynthis and Cuscuta reflexa.

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Investigation of the topical application of procyanidin oligomers from apples to identify their potential use as a hair‐growing agent

Cited by 28 publications

References 19 publications

Efficacy of Off-Label Topical Treatments for the Management of Androgenetic Alopecia: A Review

Efficacy of Off-Label Topical Treatments for the Management of Androgenetic Alopecia: A Review

Induction of Hair Keratins Expression by an Annurca Apple-Based Nutraceutical Formulation in Human Follicular Cells

A bibliometric study of scientific literature in Scopus on botanicals for treatment of androgenetic alopecia

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