Investigation of the relationship between neutrophil-to-lymphocyte ratio and obstructive sleep apnoea syndrome

Yenigün, Alper; Karamanli, Harun

doi:10.1017/s0022215115001747

Cited by 29 publications

(19 citation statements)

References 24 publications

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“…1 Therefore, in our study, there was no difference between the body mass indices and mean ages of the groups ( p = 0.20 and p = 0.415 respectively). The neutrophil-to-lymphocyte ratio is now accepted as a significant predictor of adverse clinical outcomes, and various studies have found neutrophil-to-lymphocyte ratio to be a reliable biomarker in oncology, 2,3 cardiology, 4,5 and several other diseases accompanied by systemic inflammation such as Alzheimer's disease, ulcerative colitis, appendicitis and chronic kidney disease.…”

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confidence: 43%

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Investigation of the relationship between neutrophil-to-lymphocyte ratio and obstructive sleep apnoea syndrome

Bakshi

2015

J. Laryngol. Otol.

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confidence: 43%

“…For this reason, more studies have been conducted in recent years examining the association of neutrophil-to-lymphocyte ratio with inflammation. [1][2][3][4][5][6][7][8][9] The results of our study demonstrated that the neutrophilto-lymphocyte ratio values had a positive correlation with the severity of obstructive sleep apnoea syndrome (OSAS). …”

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confidence: 99%

Investigation of the relationship between neutrophil-to-lymphocyte ratio and obstructive sleep apnoea syndrome

Bakshi

2015

J. Laryngol. Otol.

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“…These findings support the opinion that as obesity levels increase inflammation also increases. In a study by Yenigun et al a positive correlation was found between the severity of OSAS and NLR and it was also shown that as AHI increased NLR also increased (27).…”

Section: Discussionmentioning

confidence: 87%

Obez olan ve olmayan OSAS’lı olgularda nötrofil lenfosit oranının önemi var mı?

Bozkuş¹,

Dikmen²,

Samur³

et al. 2018

Tuberk Toraks

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SuMMArYDoes the neutrophil-to-lymphocyte ratio have any importance between subjects with obstructive sleep apnea syndrome with obesity and without obesity? Introduction: An increase in the incidence of OSAS (obstructive sleep apnoea syndrome) has been seen due to the reported association between OSAS and obesity. Subjects are predisposed to cardiovascular disease due to systemic inflammation caused by the interactions between obesity and OSA. Inflammatory markers could be used to predict the degree of systemic inflammation, which could be a prognostic factor for future adverse events such as metabolic risks. One marker that has recently started being used as an indicator of systemic inflammation is neutrophil-to-lymphocyte ratio (NLR).

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“…Yenigun A et al evaluated the relationship between OSAS and NLR and found a positive correlation between NLR and AHI in patients with OSAS (22). In another study done in patients with metabolic syndrome showed increased NLR (23).…”

Section: Discussionmentioning

confidence: 99%

Relationship of Potential Inflammatory Markers Namely Neutrophile Lymphocyte Ratio and Platelet Lymphocyte Ratio With the Severity of Obstructive Sleep Apnea

Dikbaş¹,

Erten²,

Küçüker³

et al. 2017

Turk J Diab Obes

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Amaç: Bu çalışmanın amacı tıkayıcı uyku apnesi (OSAS) olan hastalarda hematolojik parametrelerin değerlendirilmesidir. Gereç ve Yöntemler: Bu araştırmada uyku laboratuvarında Polisomnografi testi yapılan hastalar geriye dönük olarak değerlendirilmiştir. Kanser, kardiyovasküler hastalık, hematolojik bozukluk, enfeksiyon hastalıkları, romatolojik hastalıklar, renal ve hepatik yetmezlik olan hastalar çalışmaya alınmamıştır. Çalışmaya apne-hipopne endeksi 5 olaydan fazla olan 210 hasta ve 57 AHI 5 den az olan kontrol olarak alınmıştır. Araştırma grubu polisomnografideki AHI skorlarına göre 4 gruba ayrılmıştır: hafif OSAS (AHI= 5-15), orta OSAS (AHI=15-30), ciddi OSAS (AHI> 30), ve kontrol (AHI<5). Hematolojik parametreler değerlendirilmiş ve karşılaştırılmıştır. Bulgular: Trombosit lenfosit oranı OSAS hastalarında kontrol grubuna göre anlamlı düşük saptanmıştır. (p = 0.050). OSAS ve kontrol grupları arasında nötrofil lenfosit oranı yönünden istatistiksel olarak anlamlı farklılık izlenmemiştir (p = 0.947). Serum trigliserid ve ortalama trombosit hacmi OSAS hastalarında anlamlı yüksek izlenmiştir (p < 0.0001; p = 0.043). Trombosit dağılım hacmi ciddi OSAS grubunda kontrol grubuna ve diğer OSAS alt gruplarına göre anlamlı yüksek saptanmıştır. (p = 0.014). Sonuç: OSAS ve NLR arasında herhangi bir ilişki izlenmemiştir. NLR, PLR, ve OSAS arasındaki olası ilişki üzerine hâlâ araştırmaların sonuçları tartışmalıdır. Anahtar Sözcükler: Tıkayıcı uyku apne sendromu, OSAS, Nötrofil lenfosit oranı, Platelet lenfosit oranı ABSTrAcTAim: The aim of the present study is to evaluate hematological parameters in patients with obstructive sleep apnea syndrome (OSAS). Material and Methods:Patients underwent a polysomnographic (PSG) test at our sleep laboratory was retrospectively reviewed. Patients with cancer, cardiovascular disease, hematologic disorders, infectious diseases and rheumatologically disorders, renal or hepatic insufficiency were excluded from the study. Two hundred and ten OSAS patients with an apnea-hypopnea index (AHI) of more than five events and 57 controls with an AHI of less than four events were included. Study population was divided into four groups depending on the AHI as: mild OSAS (AHI= 5-15), moderate OSAS (AHI=15-30), severe OSAS (AHI>30), and the control (AHI<5). Hematologic parameters were measured and compared. results: Platelet lymphocyte ratio was significantly lower in patients with OSAS compared to the control (p = 0.050). Neutrophil lymphocyte ratio between OSAS and the control was not different (p = 0.947). Serum triglyceride level and mean platelet volume were significantly higher in patients with OSAS (p < 0.0001; p = 0.043). Platelet distribution width was significantly higher in severe OSAS group compared to control, mild and moderate OSAS subgroups (0.014). conclusion: No relationship was found between OSAS and NLR. There is a debate over putative relationship between NLR, PLR, and OSAS.

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Investigation of the relationship between neutrophil-to-lymphocyte ratio and obstructive sleep apnoea syndrome

Abstract: Neutrophil-to-lymphocyte ratio may be used to determine disease severity, complementing polysomnography.

Cited by 29 publications

References 24 publications

Investigation of the relationship between neutrophil-to-lymphocyte ratio and obstructive sleep apnoea syndrome

Investigation of the relationship between neutrophil-to-lymphocyte ratio and obstructive sleep apnoea syndrome

Obez olan ve olmayan OSAS’lı olgularda nötrofil lenfosit oranının önemi var mı?

Relationship of Potential Inflammatory Markers Namely Neutrophile Lymphocyte Ratio and Platelet Lymphocyte Ratio With the Severity of Obstructive Sleep Apnea

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