Investigation of the protective effect of nesfatin‐1 on testicular ischaemia‐reperfusion damage: An experimental study

Abstract

First described in the 1800s, testicular torsion is a urological disease that requires urgent intervention (Yagmurdur et al., 2006). The disease is mostly seen in adolescence and childhood (Yagmurdur et al., 2006). The aetiology of ischaemic damage from testicular torsion includes oxidative stress and inflammation due to reactive oxygen species (ROS); this process is called the ischaemic injury period (Wu, 1997). The extent of testicular damage primarily depends on the reduction of oxygen in the testicle. After the torsion is corrected, reperfusion injury begins with the formation of ROS products (Wu, 1997). Nesfatin-1 was first found in the hypothalamus in 2006. It is a molecule consisting of 82 amino acids weighing 9.7 kDa (NUKB2; Oh-I et al., 2006). Nesfatin-1 is found not only in brain tissues but also in peripheral tissues, such as adipose tissue, stomach tissue, pancreatic islets, liver tissue and the testicles (Stengel et al., 2009; Zhang et al., 2010). Nesfatin-1 is an amino group terminal fragment derived from nucleobindin-2 (NUKB2; Oh-I et al., 2006). NUKB2, which contains proteins that play an important role in the regulation of appetite and metabolism, has been found in the paraventricular (PVN), arcuate (ARC) and supra-optic tractus solitarius nucleus of the hypothalamus and in the lateral hypothalamic area, dorsomedial hypothalamic nucleus and zona incerta, as well as the cell bodies of

Letter to the editor regarding the article 'Investigation of the protective effect of nesfatin‐1 on testicular ischaemia‐reperfusion damage: An experimental study'

“…We read with great interest the currently published article written by Erdogan et al (2020) entitled 'Investigation of the protective effect of nesfatin-1 on testicular ischaemia-reperfusion damage:…”