Investigation of the interaction of anthraquinones of Cassia occidentalis seeds with bovine serum albumin by molecular docking and spectroscopic analysis: Correlation to their in vitro cytotoxic potential

Induction of Apoptosis in HepaRG Cell Line by Aloe-Emodin through Generation of Reactive Oxygen Species and the Mitochondrial Pathway

“…Studies have shown that aloe-emodin has many pharmacological effects [10-12]. Some studies demonstrated that aloe-emodin might be one of the hepatotoxic components in Rheum palmatum L. and Cassia occidentalis [10, 21, 22].…”

“…Studies have shown that aloe-emodin has many pharmacological effects [10-12]. Some studies demonstrated that aloe-emodin might be one of the hepatotoxic components in Rheum palmatum L. and Cassia occidentalis [10, 21, 22]. Previous studies have confirmed the effectiveness of aloe-emodin in promoting anti-proliferation and apoptosis in human hepatoma cell lines through up-regulation of the expression of p53, stimulation of p21/ WAF1 and down-regulation of calpain-2 (CAPN2) and ubiquitin-protein ligase E3A (UBE3A) [33, 34].…”

“…1) is an anthraquinone polyphenol and a naturally active ingredient of Chinese herbs such as Cassia occidentalis , Rheum palmatum L. and Polygonum multiflorum Thunb, which are used as traditional medicines in many countries [10-12]. Recent studies have demonstrated that aloe-emodin possesses a wide range of biological and pharmacological activities, such as anticancer [13-15], antiviral [16], antimicrobial [17], and anti-inflammatory effects [18].…”

“…Previous studies have revealed that aloe-emodin exhibits therapeutic effects via regulation of the expressions of protein kinase C (PKC), bcl-2, caspases and members of the mitogen-activated protein kinase (MAPK) family [19, 20]. Panigrahi et al reported that methanol extracts of Cassia occidentalis seeds showed significant cytotoxicities in rat primary hepatocytes and HepG2 cells, indicating that aloe-emodin might be one of its main toxic components [10, 21]. In addition, aloe-emodin has been shown to be one of the primary toxic components of Rheum palmatum L which causes hepatic and renal toxicity in rats [22].…”

Aloe-emodin Induces Apoptosis in Human Liver HL-7702 Cells through Fas Death Pathway and the Mitochondrial Pathway by Generating Reactive Oxygen Species

“…Aloe‐emodin (Fig. ) is an anthraquinone polyphenol and a natural active ingredient of Chinese herbs, including Cassia occidentalis (Panigrahi et al ., ), Rheum palmatum L. (Huang et al ., ), and Aloe vera (Hamman, ). These herbs have been wildly used as traditional medicines in many countries, especially in eastern Asia.…”