Investigation of the effects of intranasal desmopressin on the bleeding of the patients during open septorhinoplasty: A randomized double-blind clinical trial

Akbarpour, Maliheh; Jalali, Mir-Mohammad; Akbari, Maryam; Nasirmohtaram, Sevil; Haddadi, Soudabeh; Habibi, Ali Faghih; Azad, Fateme

doi:10.1016/j.heliyon.2023.e17855

Cited by 1 publication

(1 citation statement)

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“…In a study by Akbarpour et al [14], it was found that bleeding during an open septorhinoplasty surgery can cause problems and affect the quality of the operating field in a bad way. This means that clinical results from traditional methods might not be good enough.…”

Section: Discussionmentioning

confidence: 99%

Desmopressin as a Treatment in Patients With Von Willebrand Disease: A Systematic Review

Beltran,

Jaramillo,

Vallejo

et al. 2023

Cureus

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Von Willebrand disease (VWD) and hemophilia A are the most common inherited bleeding disorders. Quantitative or qualitative von Willebrand factor (VWF) anomalies cause this disorder in men and women. VWF, a plasma glycoprotein, relies on platelets for primary hemostasis. It also carries and stabilizes factor VIII in the blood. VWD has several categories. Types 1 and 3 have partial or total VWF quantitative deficiencies. However, type 2 and its subtypes have VWF quality issues. The major treatment is desmopressin (DDAVP), which replaces endogenous VWF and factor VIII (FVIII). Plasma-derived VWF/FVIII products may also be substituted exogenously. Treatment with plasma-derived or recombinant VWF concentrates without FVIII is also possible. The purpose of this retrospective, single-center research was to evaluate DDAVP's efficacy in treating VWD based on many criteria established in the current literature. We looked at the results on Google Scholar, the Cochrane Library, and PubMed/Medline. There were a total of 10 papers found, evaluated, and accepted for inclusion in this study. A comprehensive analysis of DDVAP's role in VWD was compiled from the aforementioned papers. Various aspects of DDVAP were captured by including an analysis of complementary treatments used in surgical and clinical settings. We also describe the treatment's intended impact on the different variations of the disease. Given these results, further investigation is required to determine the most effective method for managing VWD so that it may be included in standard clinical practice.

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Section: Discussionmentioning

confidence: 99%