Investigation of the Drug Carrier Properties of Insoluble Cyclodextrin Polymer Microspheres

Abstract

The investigation of the usability of solid insoluble β-cyclodextrin polymers (βCDP) in micro-sized, controlled drug delivery systems has only recently attracted interest. Our aim was to form complexes with poorly soluble active pharmaceutical ingredients (APIs) with two types of βCDP for drug delivery applications. Solid insoluble cyclodextrin polymer of irregular shape (βCDPIS) and cyclodextrin microbeads (βCDPB) were used in the experiments. Morphology, surface area, size distribution and swelling capacity of carriers were investigated. We created complexes with two APIs, curcumin and estradiol, and applied powder X-ray diffraction, FTIR and thermal analysis (TGA/DSC) to prove the complexation. Finally, the dissolution, biocompatibility and permeation of APIs on Caco-2 cells were investigated. The size of the beads was larger than 100 µm, their shape was spherical and surfaces were smooth; while the βCDPIS particles were around 4 µm with irregular shape and surface. None of the polymers showed any cytotoxic effect on Caco-2 cells. Both carriers were able to extract curcumin and estradiol from aqueous solutions, and the dissolution test showed prolonged estradiol release. Caco-2 permeability tests were in accordance with the complexation abilities and dissolution of the complexes. This study offers useful data for further pharmaceutical applications of insoluble cyclodextrin polymers.

Electrosprayed Core (Cellulose Acetate)–Shell (Polyvinylpyrrolidone) Nanoparticles for Smart Acetaminophen Delivery

“…The amorphous state is a high-energy state over the crystalline state, and, thus, the long time period of stable existence needs fine compatibility between the co-existence components to prevent possible solid-phase separation [ 78 , 79 , 80 ]. FTIR spectra can be exploited to disclose the possible secondary interactions between the components, which include hydrogen bonding, electrostatic interactions, hydrophobic interactions, and Van Der Waals forces and are favorable to high stability [ 81 , 82 , 83 ]. The ATR-FTIR spectra of the raw materials (ATP, PVP, and CA) and their electrosprayed products (P1, P2, and P3) are included in Figure 7 .…”

Effect of Molecular Weight on the Dissolution Profiles of PEG Solid Dispersions Containing Ketoprofen

“…Corrections of environmental CO 2 and H 2 O used the built-in method of the software. Spectra were evaluated as described in our previous research [ 41 ].…”

Formulation and Investigation of CK2 Inhibitor-Loaded Alginate Microbeads with Different Excipients

“…The instrument is suitable for the direct investigation of the specimens without any surface pre-treatments. Samples were placed on a specific plate with double-sided adhesive and examined using an accelerating voltage of 5 kV [ 30 ].…”

“…The permeability assay was commenced with the addition of 400 µL of the sample solution to the apical chambers of the inserts. A 50 µL aliquot was taken from the apical and basal chamber containing PBS immediately, after 4 h and 24 h. The samples were measured with high-performance liquid chromatography (HPLC) [ 30 ].…”