volume 9, issue 1, P247-255 2017
DOI: 10.18632/aging.101156
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Marianne Nygaard, Mikael Thinggaard, Kaare Christensen, Lene Christiansen

Abstract: A large meta-analysis recently found the 5q33.3 locus to be associated with survival to ≥ 90 years and lower all-cause mortality, thus suggesting it as a third human longevity locus alongside APOE and FOXO3A. The 5q33.3 locus has previously been associated with blood pressure regulation and cardiovascular diseases in middle-aged individuals. However, part of the influence on mortality appears to be independent of cardiovascular phenotypes, and the role of the 5q33.3 locus in longevity and survival is therefore…

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