2017
DOI: 10.18632/aging.101156
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Abstract: A large meta-analysis recently found the 5q33.3 locus to be associated with survival to ≥ 90 years and lower all-cause mortality, thus suggesting it as a third human longevity locus alongside APOE and FOXO3A. The 5q33.3 locus has previously been associated with blood pressure regulation and cardiovascular diseases in middle-aged individuals. However, part of the influence on mortality appears to be independent of cardiovascular phenotypes, and the role of the 5q33.3 locus in longevity and survival is therefore… Show more

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Cited by 8 publications
(4 citation statements)
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References 29 publications
(33 reference statements)
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“…In particular the SNP, rs2149954-T, in chromosome 5q33.3 is associated with low blood pressure, and they showed that minor allele (T) carriers present lower mortality risk for CVD, eventually linking longevity with a lower risk for stroke. The authors identified for the first time a real "longevity locus" as the association observed is positive, meaning that centenarians are characterized by an high frequency of the alleles associated with low blood pressures 128 .…”
Section: The Link Between Longevity Variants and Age-related Diseasesmentioning
confidence: 99%
“…In particular the SNP, rs2149954-T, in chromosome 5q33.3 is associated with low blood pressure, and they showed that minor allele (T) carriers present lower mortality risk for CVD, eventually linking longevity with a lower risk for stroke. The authors identified for the first time a real "longevity locus" as the association observed is positive, meaning that centenarians are characterized by an high frequency of the alleles associated with low blood pressures 128 .…”
Section: The Link Between Longevity Variants and Age-related Diseasesmentioning
confidence: 99%
“…Recently, this has led to large-scale studies attempting to associate genetic variation with longevity [2,12,13]. However, so far only three loci significantly associated with human longevity or healthy human aging have been identified, genetic variations on APOE, FOXO3A and 5q3.33 [2,[14][15][16]. The APOE ε4 allele, representing a risk factor for Alzheimer's disease, has been found to be less frequent in centenarians compared to younger controls [17].…”
Section: Introductionmentioning
confidence: 99%
“…The APOE ε4 allele, representing a risk factor for Alzheimer's disease, has been found to be less frequent in centenarians compared to younger controls [17]. The Single Nucleotide Polymorphism (SNP) rs2149954 on chromosome 5q3.33 has shown to be associated with lower all-cause mortality in long-lived individuals [14,18,19].…”
Section: Introductionmentioning
confidence: 99%
“…, autofagia e extensão de vida útil celular) foram os genes que tiveram associação mais robusta com longevidade(Broer et al, 2015; . Um terceiro locus apresentou associação mais recente com longevidade, um locus intergênico no cromossomo 5q55.3, associado também a fenótipos de adipogênese, doença cardiovascular, funcionalidade física e estresse psicológico crônico(Deelen et al, 2014;Nygaard et al, 2017;Slagboom et al, 2018) Nebel et al, 2011)…”
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