Investigation of terpinen-4-ol effects on vascular smooth muscle relaxation

Maia-Joca, Rebeca Peres Moreno; Joca, Humberto C.; Ribeiro, Francisca Jéssica Penha; Nascimento, Renata Vieira do; Silva‐Alves, Kerly Shamyra da; Cruz, Jáder Santos; Coelho‐de‐Souza, Andrelina Noronha; Leal-Cardoso, José Henrique

doi:10.1016/j.lfs.2014.08.022

Cited by 16 publications

(12 citation statements)

References 25 publications

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“…Interestingly, the majority of extra-systolic contractions were observed in the micromolar range, which is close to the range that induces relaxation in aortic ring preparations(Maia-Joca et al, 2014) and approximately one order of magnitude lower than the concentration necessary to obtain the negative inotropic effect observed in our study. Additionally, several types of cardiac arrhythmia events were observed in rat ECGs under a wide range of doses, varying from 0.01 to 10 mg/kg.…”

supporting

confidence: 61%

“…These data suggest that (-)-terpinen-4-ol may decrease cardiac output by both decreasing the heart rate and stroke-volume, which would account for its hypotensive effects. However, the negative inotropic effect was only reached at relatively high concentrations, approximately one order of magnitude higher than the concentrations needed to obtain smooth muscle effects (Bezerra et al, 2000;Maia-Joca et al, 2014). By contrast, (-)-terpinen-4-ol only moderately decreased heart rate.…”

Section: Discussionmentioning

confidence: 86%

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(-)-Terpinen-4-ol changes intracellular Ca2+ handling and induces pacing disturbance in rat hearts

Gondim

Lara

Santos‐Miranda

et al. 2017

European Journal of Pharmacology

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supporting

confidence: 61%

Section: Discussionmentioning

confidence: 86%

(-)-Terpinen-4-ol changes intracellular Ca2+ handling and induces pacing disturbance in rat hearts

Gondim

Lara

Santos‐Miranda

et al. 2017

European Journal of Pharmacology

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“…Till date vasodilatory activity of limonene was not evaluated. However, other monoterpenes compounds like terpinen-4ol, carvacrol and thymol were shown to have vasodilatory activity but in much higher concentrations (up to 6000 lM) in comparison to limonene, which was 70 microM and appeared to be several fold lower from other monoterpenes (70 lM) (Peixoto-Neves et al 2010;Maia-Joca et al 2014). Selected concentration range was used to roughly ''cover'' concentrations that are feasible with the in vivo conditions (Miller et al 2013).…”

Section: Vasodilatory Activitymentioning

confidence: 99%

Sea fennel (Crithmum maritimum L.): phytochemical profile, antioxidative, cholinesterase inhibitory and vasodilatory activity

et al. 2016

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Sea fennel, a rediscovered star of the coastal cuisine, has been investigated for its phytochemical profile and biological potential. Sea fennel flowers, stems and leaves were analyzed for essential oils (EOs) isolated by hydrodistillation, as well as non-volatiles obtained by ethanolic extraction. Limonene were found to be a dominant compound in EOs and ethanolic extracts; ranging from 57.5-74.2 % and 0.7-8.1 mg/g dry plant material, respectively. In addition total phenolic content was determined for ethanolic extracts. All samples and their main phytochemicals were tested for various methods. EO and extract obtained from flowers were tested for vasodilatory activity on rat aortic rings. Antioxidant activity of EOs was extremely low in comparison to extracts, on the contrary to cholinesterase inhibition where EOs showed better activity than extracts. Flower extract and chlorogenic acid showed stronger vasodilators in comparison to EO and limonene. The obtained results point out the potential impact of the dominant compounds from EO and extract on the biological properties of the sea fennel.

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“…In addition, monoterpenes have been reported to exert significant effects on the cardiovascular system [ 8 ]. Carvacrol, thymol, eugenol, methyleugenol, 1,8-cineole, and terpinen-4-ol are small monoterpenoids, which exhibited vasorelaxant effects on isolated rat aorta [ 9 , 10 , 11 , 12 , 13 , 14 ]. Moreover, 1,8-cineole and citronellol have been reported to elicit hypotension in normotensive rats [ 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Hydroxyl Group and Vasorelaxant Effects of Perillyl Alcohol, Carveol, Limonene on Aorta Smooth Muscle of Rats

et al. 2018

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The present study used isometric tension recording to investigate the vasorelaxant effect of limonene (LM), carveol (CV), and perillyl alcohol (POH) on contractility parameters of the rat aorta, focusing in particular on the structure-activity relationship. LM, CV, and POH showed a reversible inhibitory effect on the contraction induced by electromechanical and pharmacomechanical coupling. In the case of LM, but not CV and POH, this effect was influenced by preservation of the endothelium. POH and CV but not LM exhibited greater pharmacological potency on BayK-8644-induced contraction and on electromechanical coupling than on pharmacomechanical coupling. In endothelium-denuded preparations, the order of pharmacological potency on electrochemical coupling was LM < CV < POH. These compounds inhibited also, with grossly similar pharmacological potency, the contraction induced by phorbol ester dibutyrate. The present results suggest that LM, CV and POH induced relaxant effect on vascular smooth muscle by means of different mechanisms likely to include inhibition of PKC and IP3 pathway. For CV and POH, hydroxylated compounds, it was in electromechanical coupling that the greater pharmacological potency was observed, thus suggesting a relative specificity for a mechanism likely to be important in electromechanical coupling, for example, blockade of voltage-dependent calcium channel.

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Investigation of terpinen-4-ol effects on vascular smooth muscle relaxation

Cited by 16 publications

References 25 publications

(-)-Terpinen-4-ol changes intracellular Ca2+ handling and induces pacing disturbance in rat hearts

(-)-Terpinen-4-ol changes intracellular Ca2+ handling and induces pacing disturbance in rat hearts

Sea fennel (Crithmum maritimum L.): phytochemical profile, antioxidative, cholinesterase inhibitory and vasodilatory activity

Hydroxyl Group and Vasorelaxant Effects of Perillyl Alcohol, Carveol, Limonene on Aorta Smooth Muscle of Rats

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