Investigation of Plantago ovata Husk as Pharmaceutical Excipient for Solid Dosage Form (Orodispersible Tablets)

Abstract

The objective of the study was to investigate the suitability of the Plantago ovata (PO) husk as a pharmaceutical excipient. Various phytoconstituents of the husk were determined according to the standard test procedures. The Plantago ovata husk was evaluated for various pharmaceutical parameters related to flow, swelling index, and compressibility index. Orodispersible tablets (ODTs) were prepared, containing different concentrations (2.5, 3, 5, 7.5, 10, and 15% w / w ) of the Plantago ovata husk. Before compression, all the formulations were evaluated for their flow. Compressed ODTs were evaluated for physical characteristics (physical appearance, weight and weight variation, thickness, and moisture content), mechanical strength (crushing strength, specific crushing strength, tensile strength, and friability), disintegration behavior (disintegration time and oral disintegration time), drug content, and in vitro drug release. Phytochemical evaluation of the Plantago ovata husk confirmed the presence of various phytoconstituents like alkaloids, tannins, glycosides, saponins, flavonoids, and phenols. SEM photograph of the Plantago ovata husk showed that it has a fibrous structure, with a porous and rough surface. The Plantago ovata husk had a high swelling index (380%) which decreased by pulverization (310%). Precompression evaluation of the powder blend for all the formulations of ODTs showed good flow properties, indicating that the Plantago ovata husk improved the rheological characteristics of the powder blend. Compressed ODTs had good mechanical strength, and their friability was within the official limits (<1%). Best disintegration was observed with formulation F-6 containing 10% w / w of the Plantago ovata husk. It is concluded that the Plantago ovata husk can be used as a disintegrant in the formulation of ODTs.

Assessment of Iris albicans lange as potential antimicrobial and analgesic agent

“…This filtrate was reacted with Mayer's reagent (potassium mercuric iodide) and checked the precipitate growth. Appearance of yellow color precipitate confirmed alkaloids presence [14,15].…”

“…Crude extract of iris albicans and its corresponding fractions (IACCF) were evaluated for their phytochemical constituents using standard protocols [13][14][15]. These protocols and procedure were related to identification of phyto-constituents like phenolic compounds, glycosides, alkaloids, saponins, terpenoids, flavonoids, anthraquinones, steroids and tannins as described [14,15].…”

“…Alcoholic α-naphthol solution (3 drops) was added to filtrate, taken in a test tube and observed the junction. Presence of carbohydrates was confirmed by appearance of violet ring at the junction [14,15].…”

“…Afterward the test tube was placed in stand for ~15 min and noted the results. Strongly positive (+++) meant more than 5 cm froth, (++) meant more than 2 cm froth, (+) meant <1 cm froth and (-) represent no froth [14,15].…”

“…Filtrate was reacted with ferric chloride solution (3-4 drops) and observed formation of precipitate. The appearance of bluish black color precipitate indicated presence of phenol [14,15]. Test for glycosides.…”