Investigation of perfusion impairment in degenerative cervical myelopathy beyond the site of cord compression

Abstract

The aim of this study was to determine tissue-specific blood perfusion impairment of the cervical cord above the compression site in patients with degenerative cervical myelopathy (DCM) using intravoxel incoherent motion (IVIM) imaging. A quantitative MRI protocol, including structural and IVIM imaging, was conducted in healthy controls and patients. In patients, T2-weighted scans were acquired to quantify intramedullary signal changes, the maximal canal compromise, and the maximal cord compression. T2*-weighted MRI and IVIM were applied in all participants in the cervical cord (covering C1–C3 levels) to determine white matter (WM) and grey matter (GM) cross-sectional areas (as a marker of atrophy), and tissue-specific perfusion indices, respectively. IVIM imaging resulted in microvascular volume fraction ($$F$$ F ), blood velocity ($$D^{*}$$ D ∗ ), and blood flow ($$F \cdot D^{*}$$ F · D ∗ ) indices. DCM patients additionally underwent a standard neurological clinical assessment. Regression analysis assessed associations between perfusion parameters, clinical outcome measures, and remote spinal cord atrophy. Twenty-nine DCM patients and 30 healthy controls were enrolled in the study. At the level of stenosis, 11 patients showed focal radiological evidence of cervical myelopathy. Above the stenosis level, cord atrophy was observed in the WM (− 9.3%; p = 0.005) and GM (− 6.3%; p = 0.008) in patients compared to healthy controls. Blood velocity (BV) and blood flow (BF) indices were decreased in the ventral horns of the GM (BV: − 20.1%, p = 0.0009; BF: − 28.2%, p = 0.0008), in the ventral funiculi (BV: − 18.2%, p = 0.01; BF: − 21.5%, p = 0.04) and lateral funiculi (BV: − 8.5%, p = 0.03; BF: − 16.5%, p = 0.03) of the WM, across C1–C3 levels. A decrease in microvascular volume fraction was associated with GM atrophy (R = 0.46, p = 0.02). This study demonstrates tissue-specific cervical perfusion impairment rostral to the compression site in DCM patients. IVIM indices are sensitive to remote perfusion changes in the cervical cord in DCM and may serve as neuroimaging biomarkers of hemodynamic impairment in future studies. The association between perfusion impairment and cervical cord atrophy indicates that changes in hemodynamics caused by compression may contribute to the neurodegenerative processes in DCM.

Extrapyramidal spinal tracts impairment in patients with degenerative cervical myelopathy evaluated with the magnetization transfer saturation technique

“…A recently published study that used spinal cord perfusion MRI in different white matter tracts also suggested perfusion impairment predominantly in the ventral areas of the spinal cord 27 .…”

Test-retest repeatability of intravoxel incoherent motion (IVIM) measurements in the cervical cord

“…Of note, a clinical study has investigated perfusion impairment in patients with degenerative cervical myelopathy compared to healthy subjects, using the current IVIM protocol 49 . The results showed a significant decrease in 𝐷 * and 𝐹 • 𝐷 * , with an average difference of -9.5% and -15.9% in the white matter and -11.0 % and -14.4% in the grey matter, respectively, at the group level (29 DCM patients, 30 healthy subjects), using the voxel-wise one-step fit.…”