Investigation of microemulsion microstructure and its impact on skin delivery of flufenamic acid

Mahrhauser, Denise-Silvia; Kählig, Hanspeter; Partyka-Jankowska, E.; Peterlik, Herwig; Binder, Lisa; Kwizda, Kristina; Valenta, Claudia

doi:10.1016/j.ijpharm.2015.05.056

Cited by 25 publications

(10 citation statements)

References 25 publications

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“…In the case of microemulsion formulations, the Q 8h and D 8h were remarkably enhanced about 14.8~33.0-fold and 1.53~14.1-fold, respectively. This finding agreed with earlier studies reporting that drug permeability can be remarkably enhanced by using nanoscale carriers [11][12][13][14][15][16][17][18]…”

Section: In Vitro Permeation and Accumulation Studysupporting

confidence: 93%

Gel-Based Nanocarrier for Intravesical Chemotherapy Delivery: In Vitro and In Vivo Study

et al. 2020

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Intravesical administration of chemotherapeutic agents can enhance drug accumulation in tumors and reduce systemic side effects. Nanocarriers were developed for intravesical administration and exploit the permeation enhancement effect. In vitro permeation evaluation, the drug transdermal amount and accumulation amounts in the tissue of gemcitabine-loaded nanocarriers through biological membrane significantly increased about 14.8~33.0-fold and 1.5~14.1-fold respectively, when compared to a control group of 1% gemcitabine saline solution. In in vivo intravesical administration, the drug accumulation amount in bladder tissue of nanocarrier of 75.2 ± 5.4 μg was revealed as being comparably higher than that of the control group of 44.8 ± 6.4 μg. In confocal laser scanning microscopy imagery, the penetration depth of fluorescent dyes-rhodamine was increased from 80 μm up to 120 μm when a nanocarrier was used. This result implies that the nanocarrier is a promising drug delivery agent for intravesical administration.

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Section: In Vitro Permeation and Accumulation Studysupporting

confidence: 93%

Gel-Based Nanocarrier for Intravesical Chemotherapy Delivery: In Vitro and In Vivo Study

et al. 2020

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“…A number of NSAIDs have been available as gel and cream formulations for many years. There is extensive literature focused on the development and evaluation of ME and NE systems for topical delivery of a number of NSAIDs including diclofenac [ 62 , 63 ], aceclofenac [ 57 , 64 , 65 ], piroxicam [ 66 ], indomethacin [ 67 , 68 , 69 ], ibuprofen, celecoxib [ 70 , 71 ], etoricoxib [ 72 ], naproxen [ 73 ], flufenamic acid [ 50 , 74 , 75 ], ketoprofen [ 39 , 76 , 77 ], flurbiprofen [ 78 ], lornoxicam [ 79 ], and meloxicam [ 80 ]. Consequently, we have focused our discussion on this drug class to illustrate the development and potential of ME/NE formulations for topical and transdermal delivery.…”

Section: Skin Delivery From Nano and Microemulsionsmentioning

confidence: 99%

“…Oleic acid-based ME have also been investigated for skin delivery of flufenamic acid [ 74 , 75 , 83 ]. Mahrhauser et al [ 75 ] combined a fluorosurfactant (Hexafor TM 670 or Chemguard S-550-100) with isopropyl alcohol as cosurfactant (total S + CoS 65% w / w ) to form an anisotropic ME with oleic acid (10% w / w ) and water (25% w / w ), loaded with flurbiprofen. Physical characterisation using conductivity, SAXS and NMR showed that the ME was oil in water with spherical or rod-shaped microstructures.…”

Section: Skin Delivery From Nano and Microemulsionsmentioning

confidence: 99%

Topical Nano and Microemulsions for Skin Delivery

et al. 2017

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Nanosystems such as microemulsions (ME) and nanoemulsions (NE) offer considerable opportunities for targeted drug delivery to and via the skin. ME and NE are stable colloidal systems composed of oil and water, stabilised by a mixture of surfactants and cosurfactants, that have received particular interest as topical skin delivery systems. There is considerable scope to manipulate the formulation components and characteristics to achieve optimal bioavailability and minimal skin irritancy. This includes the incorporation of established chemical penetration enhancers to fluidize the stratum corneum lipid bilayers, thus reducing the primary skin barrier and increasing permeation. This review discusses nanosystems with utility in skin delivery and focuses on the composition and characterization of ME and NE for topical and transdermal delivery. The mechanism of skin delivery across the stratum corneum and via hair follicles is reviewed with particular focus on the influence of formulation.

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“…FFA is an anthranilic acid derivative that inhibits both forms of cyclooxygenase izoenzymes, and is accountable for prostaglandin biosynthesis [ 17 , 18 , 19 , 20 ]. FFA demonstrated its anti-inflammatory and analgesic potential in various topical marketed formulations intended for use in different rheumatic disorders and soft tissue injuries [ 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Development, Optimization and In Vitro/In Vivo Characterization of Collagen-Dextran Spongious Wound Dressings Loaded with Flufenamic Acid

et al. 2017

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The aim of this study was the development and optimization of some topical collagen-dextran sponges with flufenamic acid, designed to be potential dressings for burn wounds healing. The sponges were obtained by lyophilization of hydrogels based on type I fibrillar collagen gel extracted from calf hide, dextran and flufenamic acid, crosslinked and un-crosslinked, and designed according to a 3-factor, 3-level Box-Behnken experimental design. The sponges showed good fluid uptake ability quantified by a high swelling ratio. The flufenamic acid release profiles from sponges presented two stages—burst effect resulting in a rapid inflammation reduction, and gradual delivery ensuring the anti-inflammatory effect over a longer burn healing period. The resistance to enzymatic degradation was monitored through a weight loss parameter. The optimization of the sponge formulations was performed based on an experimental design technique combined with response surface methodology, followed by the Taguchi approach to select those formulations that are the least affected by the noise factors. The treatment of experimentally induced burns on animals with selected sponges accelerated the wound healing process and promoted a faster regeneration of the affected epithelial tissues compared to the control group. The results generated by the complex sponge characterization indicate that these formulations could be successfully used for burn dressing applications.

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Investigation of microemulsion microstructure and its impact on skin delivery of flufenamic acid

Cited by 25 publications

References 25 publications

Gel-Based Nanocarrier for Intravesical Chemotherapy Delivery: In Vitro and In Vivo Study

Gel-Based Nanocarrier for Intravesical Chemotherapy Delivery: In Vitro and In Vivo Study

Topical Nano and Microemulsions for Skin Delivery

Development, Optimization and In Vitro/In Vivo Characterization of Collagen-Dextran Spongious Wound Dressings Loaded with Flufenamic Acid

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