Investigation of histopathological effects after intra-arterial sugammadex injection in an experimental animal model

Abstract

PURPOSE: Intra-arterial injection of medications are related to mortality and morbidity. It was aimed to investigate the histopathological effects caused by two different intra-arterial doses of sugammadex, a new selective relaxant binding agent used to reverse the effects of steroidal systemic muscle relaxants used in surgeries carried out under general anesthesia. METHODS: A total of 15 rabbits were randomly divided into 3 groups. The control group was given 1 mL saline bolus into the central artery of the ear. The other two groups (Group Sgdx2 and group Sgdx16) were given 2 and 16 mg/kg sugammadex, respectively, intra-arterially. RESULTS: In control group, histopathological evaluation was in normal limits. The cross-sections belonging to Group Sgdx2 did not have any signifi cant pathological change compared with control group (p > 0.05). Edema and single-cell necrosis were signifi cantly higher in Group Sgdx16 when compared to control group (p < 0.05). In comparison to Group Sgdx2, single-cell necrosis was signifi cantly higher in Group Sgdx16 (p < 0.05). CONCLUSION: Being broadly used in anesthesia, sugammadex should be administered with care because when given by intra-arterial route it may cause tissue damage and tissue loss and the patients' arteries should be carefully checked (Tab. 2, Fig. 3, Ref. 21). Text in PDF www.elis.sk.

Nephroprotective Efficacy of Sugammadex in Ischemia-Reperfusion Injury: An Experimental Study in a Rat Model

“…Efficacy varies depending on the dose [ 22 ]. Sugammadex, which is widely used in anesthesia practice, may cause tissue damage and tissue loss when administered intra-arterially, so patients should be carefully controlled to avoid accidental injection if arterial cannulation is performed [ 24 ].…”