Investigation of circulatory cytokines in patients undergoing intensity-modulated radiotherapy (IMRT) for adenocarcinoma of the prostate and association with acute RT-induced toxicity: A prospective clinical study

Singh, Jagtar; Sohal, Sukhwinder Singh; Ahuja, Kiran; Lim, Aijye; Duncan, H. J.; Thachil, Thanuja; Ieso, Paolo De

doi:10.1016/j.cyto.2020.155108

Cited by 2 publications

(3 citation statements)

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“…To the best of our knowledge, the present study is the first to report the serum levels of TGF-β1 determined before radiotherapy and after the 25 th radiotherapy fraction in prostate cancer patients to be significantly positively associated with acute GU radiotoxicity symptoms. In contrast to our results, the study by Singh et al showed that prostate cancer patients treated with intensity-modulated radiotherapy who had a higher grade of acute GU radiotoxicity had lower plasma TGF-β1 concentrations at the end of therapy and 3 months after therapy [ 55 ]. The same inverse proportion was observed for concentrations of TGF-β1 and grades of acute GI radiotoxicity in this patient cohort [ 55 ].…”

Section: Discussioncontrasting

confidence: 99%

“…In contrast to our results, the study by Singh et al showed that prostate cancer patients treated with intensity-modulated radiotherapy who had a higher grade of acute GU radiotoxicity had lower plasma TGF-β1 concentrations at the end of therapy and 3 months after therapy [ 55 ]. The same inverse proportion was observed for concentrations of TGF-β1 and grades of acute GI radiotoxicity in this patient cohort [ 55 ]. The increased levels of circulating TGF-β1 had been associated with the risk of pulmonary radiotoxicity in patients with lung cancer [ 56 ].…”

Section: Discussioncontrasting

confidence: 99%

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Circulating levels of IL-6 and TGF-β1 in patients with prostate cancer undergoing radiotherapy: associations with acute radiotoxicity and fatigue symptoms

et al. 2022

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Background The goal of research was to investigate the possible relations between serum concentrations of IL-6 and TGF-β1, individual and clinical characteristics, and adverse effects of radiotherapy in patients with prostate cancer: acute and late genitourinary and gastrointestinal toxicity, and fatigue. Methods Thirty-nine patients with localized or locally advanced prostate cancer who were treated with radiotherapy were enrolled in this study. The acute radiotoxicity grades and fatigue levels were assessed during the radiotherapy and 1 month after the radiotherapy. Estimation of the late radiotoxicity was performed every three months in the first year, every four months in the second year, and then every six months. Serum levels of IL-6 and TGF-β1 were determined before radiotherapy and after the 25th radiotherapy fraction by ELISA. Results The significant positive association between diabetes mellitus and changes in acute genitourinary toxicity grades during the radiotherapy was observed in prostate cancer patients. In addition, patients who were smokers had significantly higher maximum fatigue levels in comparison with patients who were non-smokers. The circulating IL-6 levels were significantly higher after the 25th radiotherapy fraction in comparison with levels determined before radiotherapy. The significant positive correlations between pretreatment TGF-β1 levels and maximum genitourinary toxicity grades and between TGF-β1 levels after the 25th fraction and genitourinary toxicity grades after the 25th fraction, were found. The pretreatment IL-6 concentrations and TGF-β1 concentrations after the 25th fraction were positively correlated with maximum genitourinary toxicity grades. The IL-6 levels after the 25th fraction were positively associated with genitourinary toxicity grades after this fraction. The pretreatment IL-6 concentrations were significantly positively correlated with maximum fatigue scores. The significant positive correlation between IL-6 concentrations and fatigue scores after the 25th fraction was determined. The positive correlations between IL-6 and TGF-β1 concentrations measured after the 25th fraction and maximum fatigue scores were observed. Conclusions Our results suggest that serum levels of IL-6 and TGF-β1 might influence the severity of acute genitourinary radiotoxicity and fatigue in patients with prostate cancer. Combining clinical parameters and circulating cytokine levels might be useful for the prediction of adverse reactions to radiotherapy.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussioncontrasting

confidence: 99%

Circulating levels of IL-6 and TGF-β1 in patients with prostate cancer undergoing radiotherapy: associations with acute radiotoxicity and fatigue symptoms

et al. 2022

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“…Patients with PCa often experience fatigue, prostate atrophy, physiological complications of the urogenital tract, such as bladder and/or erectile dysfunction, urinary incontinence, infertility, diarrhoea, and rectal bleeding, and rarely secondary tumour development, which influences their quality of life (14). However, current pre-treatment assessments cannot be used to predict acute or late RT-induced toxicity (15). Therefore, novel biomarkers are required in RT oncology to predict RT-induced toxicity and improve decision-making, treatment and therapy monitoring of patients with PCa.…”

Section: Expression Of Micrornas Following Radiation Therapy and Asso...mentioning

confidence: 99%

Expression of microRNAs following radiation therapy and association with severity of radiotherapy‑induced toxicity among patients with prostate adenocarcinoma: A systematic review and meta‑analysis

Singh,

Thachil,

Misir

et al. 2024

World Acad Sci J

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Radiation-induced normal tissue toxicity is a common acute and chronic outcome of radiotherapy (RT) for prostate cancer (PCa). There are currently no existing pre-assessments before treatment to predict acute and late RT-induced toxicity. Novel predictive blood biomarkers in radiation oncology may improve treatment decision-making and therapeutic monitoring for patients with PCa. A comprehensive systematic search of microRNA (miRNA/miR) profiling studies published in PubMed, Science Direct and Google Scholar was performed. The present systematic review, supported by meta-analysis, summarises key findings and discusses the results of prospective clinical studies investigating miRNA expression levels and their association with RT-induced toxicity in PCa. Out of seven clinical studies, six highlighted levels of 10 miRNAs changing in plasma, serum or peripheral blood mononuclear cells during RT. The post-RT expression levels of miRNA-132-5p, miRNA-1-3p, miRNA-410 and miRNA-221 were increased, and miRNA-23a-3p expression was decreased among patients with low-grade RT-induced toxicity. Furthermore, in patients with high-grade RT toxicity, miRNA-197-3p, miRNA-151a-5p, miRNA-18b-5p, miRNA-99a and miRNA-21 expression was increased, while miRNA-132-5p expression was decreased. The present miRNA meta-analysis could be the focus of future studies to identify their potential clinical value as PCa biomarkers and therapeutic mediators in RT-induced toxicity. The variations in miRNA levels post-RT could be used as predictive biomarkers of RT-induced toxicity. However, further extensive validation is required to establish the relationship between miRNA expression levels and RT-induced toxicity in PCa and to confirm their predictive value.

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Investigation of circulatory cytokines in patients undergoing intensity-modulated radiotherapy (IMRT) for adenocarcinoma of the prostate and association with acute RT-induced toxicity: A prospective clinical study

Cited by 2 publications

References 38 publications

Circulating levels of IL-6 and TGF-β1 in patients with prostate cancer undergoing radiotherapy: associations with acute radiotoxicity and fatigue symptoms

Circulating levels of IL-6 and TGF-β1 in patients with prostate cancer undergoing radiotherapy: associations with acute radiotoxicity and fatigue symptoms

Expression of microRNAs following radiation therapy and association with severity of radiotherapy‑induced toxicity among patients with prostate adenocarcinoma: A systematic review and meta‑analysis

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