Investigation of biphasic calcium phosphate/gelatin nanocomposite scaffolds as a bone tissue engineering

Bakhtiari, Leila; Rezaie, Hamid Reza; Hosseinalipour, Seyed Mohamad; Shokrgozar, Mohammad Ali

doi:10.1016/j.ceramint.2010.07.012

Cited by 57 publications

(36 citation statements)

References 21 publications

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“…It is inexpensive, widely available, and mass producible [62]. Chitosan, a partial derivative of chitin, has received much attention because of its excellent biocompatibility and biodegradability [23].…”

Section: Stress Shieldingmentioning

confidence: 99%

“…HAp scaffolds stimulate cell attachment, growth, and differentiation [23,48,66], even though they degrade at a very slow rate [67]. -tricalcium phosphate ( -TCP) is the second most widely used CaP ceramic in bioengineering, and its alkaline nature makes it a good candidate for hybrid scaffolds to counteract the acidity resulting from polymer breakdown [8,27,46,62,68]. -TCP degrades much faster than HAp and is known for its excellent biocompatibility and osteoconductivity that stimulates the proliferation and differentiation of cells [46].…”

Section: Current Bioceramics Being Investigatedmentioning

confidence: 99%

“…HAp [23,44,46,51,[59][60][61][62] is the most commonly used ceramic biomaterial in orthopedic applications because of its biocompatibility [63][64][65]. HAp scaffolds stimulate cell attachment, growth, and differentiation [23,48,66], even though they degrade at a very slow rate [67].…”

Section: Current Bioceramics Being Investigatedmentioning

confidence: 99%

“…Col-I is sometimes associated with immunogenic responses from the host as well as pathogen transmission. However, the major problems associated with collagen are its cost, solubility, and lack of commercial sources [62]. Gelatin collagen is the denatured version of collagen and does not have the same drawbacks as the naturally …”

Section: Polymer Propertiesmentioning

confidence: 99%

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Development of Composite Scaffolds for Load Bearing Segmental Bone Defects

Pilia¹,

Guda²,

Appleford³

2013

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The need for a suitable tissue-engineered scaffold that can be used to heal load-bearing segmental bone defects (SBDs) is both immediate and increasing. During the past 30 years, various ceramic and polymer scaffolds have been investigated for this application. More recently, while composite scaffolds built using a combination of ceramics and polymeric materials are being investigated in a greater number, very few products have progressed from laboratory benchtop studies to preclinical testing in animals. This review is based on an exhaustive literature search of various composite scaffolds designed to serve as bone regenerative therapies. We analyzed the benefits and drawbacks of different composite scaffold manufacturing techniques, the properties of commonly used ceramics and polymers, and the properties of currently investigated synthetic composite grafts. To follow, a comprehensive review of in vivo models used to test composite scaffolds in SBDs is detailed to serve as a guide to design appropriate translational studies and to identify the challenges that need to be overcome in scaffold design for successful translation. This includes selecting the animal type, determining the anatomical location within the animals, choosing the correct study duration, and finally, an overview of scaffold performance assessment.

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Section: Stress Shieldingmentioning

confidence: 99%

Section: Current Bioceramics Being Investigatedmentioning

confidence: 99%

Section: Current Bioceramics Being Investigatedmentioning

confidence: 99%

Section: Polymer Propertiesmentioning

confidence: 99%

See 2 more Smart Citations

Development of Composite Scaffolds for Load Bearing Segmental Bone Defects

Pilia¹,

Guda²,

Appleford³

2013

View full text Add to dashboard Cite

show abstract

“…[50,51] Degradation of synthetic polymers are generally occurred by simple hydrolysis. [52] PGA:-The first attempt for pulp tissue engineering in vitro was achieved using PGA with human pulpal fibroblasts. A new tissue-like construct with similar cellularity as in normal pulp tissue could be observed.…”

Section: Issn: 2320-5407mentioning

confidence: 99%