Investigation of Antiviral Potential of Licorice (Glycyrrhiza Glabra L.) Crude Extract Against Tobacco Mosaic Virus

doi:10.36899/japs.2020.1.0013

Cited by 3 publications

(1 citation statement)

References 30 publications

(42 reference statements)

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“…Plants extracts and pure compounds have been described as potential tools to manage different crop pests and weeds, due to easily available sources, low cost, biodegradability, varied modes of action, and low toxicity to non-targeted organisms [ 25 , 26 , 27 , 28 , 29 ]. Activity of plant compounds against phyto-viruses has been reported [ 30 , 31 , 32 ]. Plant phenolic compounds are involved in plant defense [ 33 , 34 ] and show several properties against a wide spectrum of plant pathogens [ 35 , 36 ], specifically against various viruses, including tobamoviruses [ 37 , 38 , 39 , 40 ].…”

Section: Introductionmentioning

confidence: 99%

Autoxidation Products of the Methanolic Extract of the Leaves of Combretum micranthum Exert Antiviral Activity against Tomato Brown Rugose Fruit Virus (ToBRFV)

Iobbi

Lanteri²,

Minuto³

et al. 2022

Molecules

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Tomato brown rugose fruit virus (ToBRFV) is a new damaging plant virus of great interest from both an economical and research point of view. ToBRFV is transmitted by contact, remains infective for months, and to-date, no resistant cultivars have been developed. Due to the relevance of this virus, new effective, sustainable, and operator-safe antiviral agents are needed. Thus, 4-hydroxybenzoic acid was identified as the main product of the alkaline autoxidation at high temperature of the methanolic extract of the leaves of C. micranthum, known for antiviral activity. The autoxidized extract and 4-hydroxybenzoic acid were assayed in in vitro experiments, in combination with a mechanical inoculation test of tomato plants. Catechinic acid, a common product of rearrangement of catechins in hot alkaline solution, was also tested. Degradation of the viral particles, evidenced by the absence of detectable ToBRFV RNA and the loss of virus infectivity, as a possible consequence of disassembly of the virus coat protein (CP), were shown. Homology modeling was then applied to prepare the protein model of ToBRFV CP, and its structure was optimized. Molecular docking simulation showed the interactions of the two compounds, with the amino acid residues responsible for CP-CP interactions. Catechinic acid showed the best binding energy value in comparison with ribavirin, an anti-tobamovirus agent.

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Section: Introductionmentioning

confidence: 99%

Autoxidation Products of the Methanolic Extract of the Leaves of Combretum micranthum Exert Antiviral Activity against Tomato Brown Rugose Fruit Virus (ToBRFV)

Iobbi

Lanteri²,

Minuto³

et al. 2022

Molecules

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Biosynthesis of cupric oxide nanoparticles: its antiviral activities against TMV by directly destroying virion and inducing plant resistance

Liu,

Tian,

Liu

et al. 2024

Phytopathol Res

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Tobacco mosaic virus (TMV) is widely recognized as one of the most important plant viruses, causing significant agricultural losses in terms of both quality and yield worldwide each year. This study demonstrated the biosynthesis of copper oxide nanoparticles (CuONPs) using orange peel extract for effective control of TMV infection both in vitro and in vivo. After treatment with CuONPs (100 mg/L) for 2 h, TMV particles exhibited evident fragmentation in vitro, reducing infectivity on tobacco plants. Similarly, the application of CuONPs on Nicotiana benthamiana (N. benthamiana) positively impeded viral replication and accumulation in vivo. Interestingly, the expression of systemic resistance-related genes (PR1, PR2, ERF1, and JAZ3) in the host plant was up-regulated by CuONPs treatment, supporting that CuONPs activated plant immunity to inhibit TMV. Importantly, the application of CuONPs (100 mg/L) did not exhibit any toxic effects on tobacco and, instead, resulted in the promotion of chlorophyll content, as well as an increase in the fresh weight and dry weight of the plant when compared to the control treatment. Overall, we proposed that the appropriate concentration of CuONPs (100 mg/L) can directly break viral particles by passivating, boost plant immunity by stimulating systemic acquired resistance (SAR), and provide nutritional supplements to promote plant growth.

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Antiviral Properties of Various Bioactive Components Present in the Root of Glycyrrhiza glabra: Review

Joseph

Shrivastava

Benny

et al. 2023

CNF

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The plant, Glycyrrhiza glabra species (liquorice or licorice), a flowering plant of the bean family Fabaceae, is of utmost importance as it contains glycyrrhizin an important antiviral compound along with other significant phytoconstituents like glycyrrhetinic acid, glabrin A&B, triterpene sterols, isoflavones, and many more. Glycyrrhiza glabra has been recognized since time immemorial for its ethnopharmacological values, as it exhibits various pharmacological activities. The crux of this review focuses on the antiviral activity of liquorice against several viruses that pose a severe threat to humankind like herpes simplex virus (HSV), Hepatitis C virus (HCV), H5N1 virus, human immunodeficiency virus (HIV), H3N2 virus, influenza, and influenza A virus, pseudorabies virus (PrV), etc. To recapitulate, this review article explains the compilation of data obtained from Scopus indexed journal articles over 5 years ranging from 2015 to 2020, which not only aims to shed light on the application of Glycyrrhiza glabra against human viruses but also on how to develop these responses further to improve the efficacy. Further the review also focuses on of Glycyrrhiza glabra for its potential commercial uses, such as for the treatment of porcine virus in pigs and piglets, is also verified.

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Investigation of Antiviral Potential of Licorice (Glycyrrhiza Glabra L.) Crude Extract Against Tobacco Mosaic Virus

Cited by 3 publications

References 30 publications

Autoxidation Products of the Methanolic Extract of the Leaves of Combretum micranthum Exert Antiviral Activity against Tomato Brown Rugose Fruit Virus (ToBRFV)

Autoxidation Products of the Methanolic Extract of the Leaves of Combretum micranthum Exert Antiviral Activity against Tomato Brown Rugose Fruit Virus (ToBRFV)

Biosynthesis of cupric oxide nanoparticles: its antiviral activities against TMV by directly destroying virion and inducing plant resistance

Antiviral Properties of Various Bioactive Components Present in the Root of Glycyrrhiza glabra: Review

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