Investigation Of“anosmic Zones”associated With Nasal Allergy

Higo, Ryuzaburo; Ichimura, Keiichi; Ota, Yasushi; Ishizuka, Tetsuo; Shimazaki, Yuichi

doi:10.3950/jibiinkoka.99.1648

Cited by 14 publications

(6 citation statements)

References 8 publications

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“…21 Higo et al investigated smell alterations in patients with allergic rhinitis and speculated that rhinitis causes alterations in the olfactory mucosa, resulting in olfactory transduction impairment. 22 In the present study, smell alterations in group I were found in 33.3% of individuals (13 patients), and in group II, 11.1% (two patients). Three months postoperatively, only two patients did not achieve overall symptom improvement, with no difference between the two groups.…”

Section: Discussionsupporting

confidence: 50%

Impact of turbinoplasty on over all results of indicated nasal surgeries with or without allergic rhinitis incidence

Srivastava¹,

Singh²,

Singh³

et al. 2020

IJOAS

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Turbinoplasty is a procedure that aims to reduce the size of the inferior turbinate through exuberant bone removal with high mucosal preservation. The procedure is recommended for patients with or without allergic rhinitis and those showing irreversible hypertrophy of inferior turbinates.To evaluate the efficacy of inferior turbinoplasty for obstructive and non-obstructive symptoms in patients with or without allergic rhinitis.Prospective study with 57 patients who underwent inferior turbinoplasty. They were evaluated for nasal obstruction, snoring, facial pressure, smell alterations, sneezing, nasal itching and runny nose symptoms, surgery time, and intraoperative bleeding. The last evaluation took place three months after surgery.Thirty-nine patients with allergic rhinitis and 18 without it were assessed. Ninety days after surgery, 94.7% of patients showed breathing improvement; 89.5% showed moderate or complete improvement in snoring; all patients showed smell improvement; 95.5% experienced complete facial pressure improvement; and 89.7% showed moderate to complete improvement in nasal itching and runny nose symptoms, as well as in sneezing.The efficacy of inferior turbinoplasty was confirmed not only for obstructive symptoms, but also for non-obstructive symptoms in patients with and without allergic rhinitis.

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Section: Discussionsupporting

confidence: 50%

Impact of turbinoplasty on over all results of indicated nasal surgeries with or without allergic rhinitis incidence

Srivastava¹,

Singh²,

Singh³

et al. 2020

IJOAS

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“…Another study maintains that decongestion of AR patients' nasal mucosa with epinephrine drops did not normalize the olfactory function 31. These studies suggest a potential role for inflammatory changes in nasal mucosa 32. Patients with AR showed a close correlation between the loss of smell and inflammatory markers such as the eosinophilic cationic protein (ECP)13 and the blood eosinophil concentration 9.…”

Section: Discussionmentioning

confidence: 85%

Persistent allergic rhinitis has a moderate impact on the sense of smell, depending on both nasal congestion and inflammation

et al. 2009

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“…It has previously been hypothesized (14) that nVMR patients, because of their intolerance to odors and irritants, might be distinguished from patients having other forms of chronic rhinitis, due to an abnormality in their olfactory transduction pathway. Paradoxically, the limited number of studies investigating odorant discrimination found a greater magnitude of olfactory loss in nVMR patients in response to common odorants, such as formalin, camphor, asafetida (India saffron spice), and oil of peppermint-as compared with allergic rhinitis patients or control subjects without rhinitis (15).…”

Section: Introductionmentioning

confidence: 99%

Olfactory Receptor Gene Polymorphisms and Nonallergic Vasomotor Rhinitis

Bernstein

Zhang

et al. 2008

Journal of Asthma

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We sought a genotype-phenotype association: between single-nucleotide polymorphisms (SNPs) in olfactory receptor (OR) genes from the two largest OR gene clusters and odor-triggered nonallergic vasomotor rhinitis (nVMR). In the initial pedigree screen, using transmission disequilibrium test (TDT) analysis, six SNPs showed "significant" p-values between 0.0449 and 0.0043. In a second case-control population, the previously identified six SNPs did not re-emerge, whereas four new SNPs showed p-values between 0.0490 and 0.0001. Combining both studies, none of the SNPs in the TDT analysis survived the Bonferroni correction. In the population study, one SNP showed an empirical p-value of 0.0066 by shuffling cases and controls with 10 5 replicates; however, the p-value for this SNP was 0.83 in the pedigree study. This study emphasizes that underpowered studies having p-values between <0.05 and 0.0001 should be regarded as inconclusive and require further replication before concluding the study is "informative." However, we believe that our hypothesis that an association between OR genotypes and the nVMR phenotype remains feasible. Future studies using either a genomewide association study of all OR gene-pseudogene regions throughout the genome -at the current recommended density of 2.5 to 5 kb per tag SNP-or studies incorporating microarray analyses of the entire "OR genome" in well-characterized nVMR patients are required.

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Investigation Of“anosmic Zones”associated With Nasal Allergy

Abstract: Twenty-seven nasal allergy patients suffering from olfactory disturbance were evaluated in

Cited by 14 publications

References 8 publications

Impact of turbinoplasty on over all results of indicated nasal surgeries with or without allergic rhinitis incidence

Impact of turbinoplasty on over all results of indicated nasal surgeries with or without allergic rhinitis incidence

Persistent allergic rhinitis has a moderate impact on the sense of smell, depending on both nasal congestion and inflammation

Olfactory Receptor Gene Polymorphisms and Nonallergic Vasomotor Rhinitis

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