Investigation of adropin and leptin levels in pediatric obesity-related nonalcoholic fatty liver disease

Sayın, Oya; Tokgöz, Yavuz; Arslan, Nur

doi:10.1515/jpem-2013-0296

Cited by 66 publications

(61 citation statements)

References 13 publications

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“…Reduced levels of adropin have been observed in obesity-associated insulin resistance, gestational diabetes, nonalcoholic fatty liver disease (NAFLD), acute myocardial infarction, coronary atherosclerosis and endothelial dysfunction [7,8]. Sayin et al have demonstrated that low adropin concentrations were associated with the risk of NAFLD (18). It should be stressed, however, that their study involved children and not adults.…”

Section: Discussionmentioning

confidence: 99%

Afamin and adropin in patients with alcohol-induced liver cirrhosis

Prystupa¹,

Kiciński²,

Luchowska-Kocot³

et al. 2018

Ann Agric Environ Med.

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The aim of the study was to determine serum concentrations of afamin and adropin in patients with alcoholic liver cirrhosis and to define their correlation with the stage of disease. The study included 99 patients with alcoholic cirrhosis from the region of Lublin, (Eastern Poland). Liver cirrhosis was diagnosed based on clinical features, history of heavy alcohol consumption, laboratory tests and abdominal ultrasonography. The control group consisted of 20 healthy individuals without liver disease who did not abuse alcohol. The serum afamin and adropin concentrations were determined using ELISA kits. The concentration of afamin was found to be significantly lower in patients with compensated alcoholic liver cirrhosis, i.e. P-Ch B (85.1±40.6 μg/ml) and P-Ch C (56.4±32.3 μg/ml) individuals, compared to the control group (135.9±43.6 μg/ml); p-value was <0.01 and <0.001, respectively. As far as adropin is concerned, a reverse relationship was demonstrated: the highest concentration was found in patients with P-Ch C (11.7±5.7 ng/ml) cirrhosis. Furthermore, the above concentration was significantly higher compared to patients with P-Ch A cirrhosis (7.2±2.8 ng/ml; p<0.05) and controls (7.5±2.6 ng/ml; p<0.05). The concentration of afamin decreases with the severity of alcoholic liver cirrhosis, which most likely results from impaired hepatic synthesis. Otherwise, the higher the stage of disease according to the Child-Pugh score, the higher the concentration of adropin.

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Section: Discussionmentioning

confidence: 99%

Afamin and adropin in patients with alcohol-induced liver cirrhosis

Prystupa¹,

Kiciński²,

Luchowska-Kocot³

et al. 2018

Ann Agric Environ Med.

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“…Correlations between circulating adropin levels and different pathophysiological states in mice and humans have been reported (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14). In brief, the circulating concentration of adropin was reduced markedly in several metabolic diseases, including obesity-associated insulin resistance (1,5,11); obesity-related, nonalcoholic fatty liver disease (11); gestational diabetes mellitus (7); and endothelial dysfunction (6,8,14). However, conversely, other studies found that plasma adropin levels in humans were not correlated inversely with obesity on the basis of body mass index (6,8,13) or with endothelial dysfunction (9).…”

mentioning

confidence: 99%

Adropin Is a Brain Membrane-bound Protein Regulating Physical Activity via the NB-3/Notch Signaling Pathway in Mice

Wong

Wang²,

Lee³

et al. 2014

Journal of Biological Chemistry

101

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Background:The mechanism of action of adropin on metabolism remains elusive. Results: Adropin is a plasma membrane protein that can bind to the brain-specific, non-canonical Notch1 ligand NB-3. Conclusion: Adropin regulates physical activity, motor coordination, and cerebellum development in mice via the NB-3/ Notch1 signaling pathway. Significance: Adropin is a highly conserved polypeptide that might also be important for cerebellum development in mammals.

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“…In literature, there are recent studies that suggest the existence of an association between adropin, and obesity and IR (1,3,9). Based on our findings, however, while a difference was present in lipid profiles and HOMA-IR values of controls and patients, consisting of children with obesity and MetS, the absence of such a difference between adropin levels of patient and control groups, and of a correlation between adropin, and weight and HOMA-IR suggested that no association is present between adropin, and obesity and IR.…”

Section: Discussionmentioning

confidence: 99%

Are obesity and metabolic syndrome associated with plasma adropin levels in children?

Kocaoğlu¹,

Buyukınan²,

Erdem³

et al. 2015

Journal of Pediatric Endocrinology and Metabolism

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Studies performed on mice suggest that adropin is a peptide hormone playing a role in metabolic homeostasis and prevention of obesity-associated insulin resistance. Our study was conducted to investigate the role of adropin in children with obesity or metabolic syndrome. The study group consisted of 70 patients, including 42 obese and 28 with metabolic syndrome, and 26 healthy volunteers. After anthropometric variables and blood pressure of all participants were measured, serum lipids were analyzed, liver USG and oral glucose tolerance test were performed, and HOMA-IR values were calculated. Plasma adropin levels were collectively analyzed from collected plasma samples. In patient and control groups, no difference was observed in the levels of adropin (327.7±124.7 vs. 344.6±208.5 ng/L, respectively). The adropin levels of metabolic syndrome, obesity, and control groups also showed no difference (316±142.3, 335.8±112.5, and 344.6±208.5 ng/L, respectively). While the adropin levels of patients with and without hepatic steatosis were 319.6±123.7 and 347.8±128.7 ng/L, respectively, patients with HOMA-IR values of < 3.16 and ≥ 3.16 had levels 342.3±124.8 and 296.5±136.7 ng/L, respectively. Although statistically insignificant, our findings are considered to support the hypothesis suggesting a nexus between adropin and obesity and metabolic syndrome. Small sample size in our study may have prevented our results to reach a more significant level. So, long-term follow-up studies with large population are needed to enlighten the role of adropin in metabolic homeostasis.

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Investigation of adropin and leptin levels in pediatric obesity-related nonalcoholic fatty liver disease

Cited by 66 publications

References 13 publications

Afamin and adropin in patients with alcohol-induced liver cirrhosis

Afamin and adropin in patients with alcohol-induced liver cirrhosis

Adropin Is a Brain Membrane-bound Protein Regulating Physical Activity via the NB-3/Notch Signaling Pathway in Mice

Are obesity and metabolic syndrome associated with plasma adropin levels in children?

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