Lília Jorge, Ricardo Martins, Nádia Canário, Carolina Xavier, Antero Abrunhosa, Isabel Santana, Miguel Castelo-Branco
Abstract:Background: It has been proposed that amyloid-β (Aβ) plays a causal role in Alzheimer’s disease (AD) by triggering a series of pathologic events—possibly including neuroinflammation—which culminate in progressive brain atrophy. However, the interplay between the two pathological molecular events and how both are associated with neurodegeneration is still unclear. Objective: We aimed to estimate the spatial inter-relationship between neurodegeneration, neuroinflammation and Aβ deposition in a cohort of in 20 mi…
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