2014
DOI: 10.1073/pnas.1411499111
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Abstract: Nanomedicines (NMs) offer new solutions for cancer diagnosis and therapy. However, extension of progression-free interval and overall survival time achieved by Food and Drug Administrationapproved NMs remain modest. To develop next generation NMs to achieve superior anticancer activities, it is crucial to investigate and understand the correlation between the physicochemical properties of NMs (particle size in particular) and their interactions with biological systems to establish criteria for NM optimization.… Show more

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Cited by 529 publications
(372 citation statements)
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“…S16). These results substantiate previous observations that smaller nanoparticles are more advantageous for deep tumor penetration than larger ones because of their reduced diffusional hindrance (23,42). To further visualize real-time extravasation and tumor penetration of these nanoparticles, intravital CLSM was used.…”
Section: Resultssupporting
confidence: 88%
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“…S16). These results substantiate previous observations that smaller nanoparticles are more advantageous for deep tumor penetration than larger ones because of their reduced diffusional hindrance (23,42). To further visualize real-time extravasation and tumor penetration of these nanoparticles, intravital CLSM was used.…”
Section: Resultssupporting
confidence: 88%
“…Such a transport process highly relies on much slower diffusion rather than faster convective transport because of the inherently large sizes of nanoparticles compared with small therapeutics (22). Particle size plays a vital role in dominating the penetration of nanoparticles into tumor tissue as diffusion scales inversely with particle size (23)(24)(25). Larger nanoparticles, despite being more advantageous for improved pharmacokinetics and high propensity of vascular extravasation (26), are inherently unfavorable for tumor penetration due to their huge diffusional hindrance in the tumor interstitial space (23,24).…”
mentioning
confidence: 99%
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“…To the best of our knowledge, this is the first report in which HBO therapy acts as a facilitative therapy for deep penetration of nanotherapeutics. A variety of methods have also been developed to bolster penetration of nanotherapeutics,37 and many of these focus on degradation of tumor ECM by delivering small molecular drugs or enzymes. Compared with these methods, HBO uses oxygen as a drug to oxygenate hypoxic tumors and modulate ECM.…”
Section: Resultsmentioning
confidence: 99%
“…As reported, 39,40 smaller particles have better ability to escape the capture of reticuloendothelial cells, penetrating deep tumor tissues and residing in the tumor for a longer time. However, there is a lower size limit for this effect.…”
mentioning
confidence: 73%