volume 25, issue 4, P635-644 2011
DOI: 10.3233/jad-2011-110197
View full text
Sign up to set email alerts

Abstract: Abstract. The missing heritability exhibited by late-onset Alzheimer's disease is unexplained and has been partly attributed to epistatic interaction. Methods available to explore this are often based on logistic regression and allow for determination of deviation from an expected outcome as a result of statistical epistasis. Three such methodologies including Synergy Factor and the PLINK modules, -epistasis and -fast-epistasis, were applied to study an epistatic interaction between interleukin-6 and interleu…

Expand abstract