Investigating forthcoming strategies to tackle deadly superbugs: current status and future vision

Mitra, Saikat; Sultana, Sifat Ara; Prova, Shajuthi Rahman; Uddin, Tanvir Mahtab; Islam, Fahadul; Das, Rajib; Nainu, Firzan; Sartini, Sartini; Chidambaram, Kumarappan; Alhumaydhi, Fahad A.; Emran, Talha Bin; Simal-Gándara, Jesús

doi:10.1080/14787210.2022.2122442

Cited by 12 publications

(3 citation statements)

References 191 publications

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“…Antimicrobial resistance (AMR) poses a significant global public health challenge, jeopardizing our ability to combat bacterial infections, as evidenced by the emergence of superbugs ( Mitra et al, 2022 ). The World Health Organization is now adopting a “One Health” approach to address global AMR, emphasizing the interconnection of humans, animals, and environmental health ( McEwen and Collignon, 2018 ; Collineau et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

High rate of multidrug resistance and integrons in Escherichia coli isolates from diseased ducks in select regions of China

et al. 2023

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Section: Introductionmentioning

confidence: 99%

High rate of multidrug resistance and integrons in Escherichia coli isolates from diseased ducks in select regions of China

et al. 2023

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“…The global rise in antibiotic resistance is alarming, partially attributed to excessive and inappropriate antibiotic use ( Ghweil et al, 2022 ; Mitra et al, 2022 ). In this study, S. epidermidis exhibited high sensitivity to tigacycline, linezolid, vancomycin, quinupristin/dalfopristin, rifampicin, furantoin, and gentamicin.…”

Section: Discussionmentioning

confidence: 99%

The impact of oxygen content on Staphylococcus epidermidis pathogenesis in ocular infection based on clinical characteristics, transcriptome and metabolome analysis

Lv,

Zhang,

Zhao

et al. 2024

Front. Microbiol.

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IntroductionThis study aims to delineate the etiology and prevalence of isolated pathogens, along with the clinical characteristics of endophthalmitis patients over a 9-year period at hospital in Southwest of China. Additionally, we investigating the metabolic and cellular processes related to environmental factors may offer novel insights into endophthalmitis.MethodsWe analyzed data pertaining to endophthalmitis patients treated at the Affiliated Hospital of Yunnan University from 2015 to 2023. According to our clinical data, we conducted an experiment based on transcriptomics and metabolomics analysis to verify whether environmental factors affect behavior of S. epidermidis by culturating S. epidermidis under oxic and microoxic condition.ResultsIn this study, 2,712 fungi or bacteria strains have been analyzed, gram-positive bacteria constituted 65.08%, with S. epidermidis being the most predominant species (25.55%). Ophthalmic trauma was the primary pathogenic factor for S. epidermidis ocular infections. Regarding fluoroquinolones, S. epidermidis exhibited the higher resistance rate to levofloxacin than moxifloxacin. Moreover, our investigation revealed that S. epidermidis in microoxic environment increase in energy metabolism, amino acid metabolism, and membrane transport.ConclusionOur findings underscore the significance of S. epidermidis as a crucial pathogen responsible for infectious endophthalmitis. It is crucial to exercise vigilance when considering Levofloxacin as the first-line drug for empiric endophthalmitis treatment. The metabolites alteration observed during the commensal-to-pathogen conversion under microoxic condition serve as a pivotal environmental signal contributing to S. epidermidis metabolism remodeling, toward more pathogenic state.

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“…The media showed perfect growth for cave actinobacteria. Antibiotic resistance is a serious concern in recent days, as WHO estimates that there will be no treatment options in the future if the rate of resistance among the bacteria continues to be the same [35,36]. The problem is that the rate of resistance in bacteria is much more than the discovery of novel antibiotics.…”

Section: Antimicrobial Activities Of Cave Actinobacteria Against Xdr ...mentioning

confidence: 99%

Exploring the Antimicrobials Production Potential of Actinobacteria Isolated from Caves at Bahadurkhel Karak, Pakistan

Nawaz

Fatima

Saleem

et al. 2023

PPASB

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Cave actinobacteria are relatively less explored and are considered as the new targets for the discovery of novel antimicrobials, specifically against highly resistant pathogens such as extensively drug-resistant (XDR) Salmonella. In this study N=20 actinobacteria isolates were retrieved from the least disturbed caves situated at Bahadurkhel Karak, Pakistan (33° 16’ 52” North, 70° 79’ 07” East) and (33° 15’ 90” North, 70° 94’ 72” East). The isolates were identified using standard morphological and biochemical characterization procedures as well as by 16S rDNA sequencing. N= 16 isolates were targeted for further antimicrobial activity screening based on their preliminary morphological and biochemical identification. The methanolic extracts were prepared from the culture broth of the isolates by using Amberlite® XAD-16 resin to execute in situ solid phase extraction. The thin layer chromatography (TLC) showed the presence of a variety of different compounds in the crude extracts of the secondary metabolites. The extracts’ antimicrobial potential was analyzed against several test strains, including Salmonella enterica, Staphylococcus aureus, Bacillus subtilis, Klebsiella pneumoniae, and Escherichia coli. Among the isolated strains, the isolates SNK 93 and SNK47 were found to be the most active against the tested pathogenic bacteria, showing growth inhibition zones of 20 mm and 27 mm respectively against extensively drug-resistant (XDR) Salmonella. Based on these results it can be concluded that cave actinobacteria are a promising source of potentially novel antimicrobials against multidrug-resistant (MDR) and XDR pathogens.

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Investigating forthcoming strategies to tackle deadly superbugs: current status and future vision

Cited by 12 publications

References 191 publications

High rate of multidrug resistance and integrons in Escherichia coli isolates from diseased ducks in select regions of China

High rate of multidrug resistance and integrons in Escherichia coli isolates from diseased ducks in select regions of China

The impact of oxygen content on Staphylococcus epidermidis pathogenesis in ocular infection based on clinical characteristics, transcriptome and metabolome analysis

Exploring the Antimicrobials Production Potential of Actinobacteria Isolated from Caves at Bahadurkhel Karak, Pakistan

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