Inverse relationship between circulating oxidized low density lipoprotein (oxLDL) and anti-oxLDL antibody levels in healthy subjects

The human IgM antibody SAM-6 induces tumor-specific apoptosis with oxidized low-density lipoprotein

“…Most of these antibodies are part of the innate immunity, and their biological function is the clearance of modified molecules, like oxidized LDL, to prevent cellular and molecular damage by oxidation. It has been found that some of these antibodies are affinity maturated auto antibodies, participating in several diseases (46), whereas others are involved in a protective process and are weapons of innate immune mechanisms (47,48). A good example is the natural IgM antibody EO6, described by Palinski et al (49,50).…”

Circulating Oxidized Low Density Lipoprotein Levels

“…It may be noteworthy that a recent report has demonstrated that plasma levels of OxLDL show an inverse relationship with the levels of antibody against OxLDL, implicating a role for autoantibodies in the regulation of OxLDL levels. 31 However, it is envisioned that numerous factors will affect oxidized levels, such as oxidative stress, the lipid content of LDL, LDL concentrations, conditions of the vascular wall, blood pressure, and clearance efficiency, to name a few. Because of this multifactorial regulation, it is likely that OxLDL levels did not show a relation to age, sex, or smoking habit.…”

Antioxidant-oxidant status in patients with hydatid cyst

“…PON1, protects LDL cholesterol from the oxidation induced by copper ion and free radicals. The PON1 enzyme found in HDL cholesterol degrades the active lipids found in minimally modified LDL and has protective effects against the formation of inflammatory response in the cells of the arterial wall [12,13]. Additionally, PON1 has arylesterase activity without polymorphism.…”