Inverse micellar sugar glass (IMSG) nanoparticles for transfollicular vaccination

Mittal, Ankit; Schulze, Kai; Ebensen, Thomas; Weißmann, Sebastian; Hansen, Steffi; Guzmán, Carlos A.; Lehr, Claus‐Michael

doi:10.1016/j.jconrel.2015.03.017

Cited by 40 publications

(25 citation statements)

References 57 publications

(75 reference statements)

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“…Transfollicular delivery of ovalbumin using polymeric NPs was recently shown to induce a significant cellular and humoral immune response, without compromising the SC barrier by any pretreatment, when combined with innovative adjuvants. 413−415 …”

Section: In Vivo Treatment (“Particle-based Delivery”)mentioning

confidence: 99%

Diverse Applications of Nanomedicine

Pelaz¹,

et al. 2017

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The design and use of materials in the nanoscale size range for addressing medical and health-related issues continues to receive increasing interest. Research in nanomedicine spans a multitude of areas, including drug delivery, vaccine development, antibacterial, diagnosis and imaging tools, wearable devices, implants, high-throughput screening platforms, etc. using biological, nonbiological, biomimetic, or hybrid materials. Many of these developments are starting to be translated into viable clinical products. Here, we provide an overview of recent developments in nanomedicine and highlight the current challenges and upcoming opportunities for the field and translation to the clinic.

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Section: In Vivo Treatment (“Particle-based Delivery”)mentioning

confidence: 99%

Diverse Applications of Nanomedicine

Pelaz¹,

et al. 2017

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“…Chloroform is also applicable for preparation of W/O emulsions prior to lyophilization . High pressure homogenization and an ultrasound method are also applicable for the formation of stable W/O emulsion precursors . The role of these techniques is comprehensively reviewed elsewhere .…”

Section: Development Of the S/o Nanodispersionsmentioning

confidence: 99%

Solid‐in‐oil nanodispersions for transdermal drug delivery systems

Kitaoka

Wakabayashi

Kamiya

et al. 2016

Biotechnology Journal

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Transdermal administration of drugs has advantages over conventional oral administration or administration using injection equipment. The route of administration reduces the opportunity for drug evacuation before systemic circulation, and enables long‐lasting drug administration at a modest body concentration. In addition, the skin is an attractive route for vaccination, because there are many immune cells in the skin. Recently, solid‐in‐oil nanodisperison (S/O) technique has demonstrated to deliver cosmetic and pharmaceutical bioactives efficiently through the skin. S/O nanodispersions are nanosized drug carriers designed to overcome the skin barrier. This review discusses the rationale for preparation of efficient and stable S/O nanodispersions, as well as application examples in cosmetic and pharmaceutical materials including vaccines. Drug administration using a patch is user‐friendly, and may improve patient compliance. The technique is a potent transcutaneous immunization method without needles.

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“…In a relevant mouse model we could recently demonstrate that transfollicular delivery of ovalbumin using polymeric nanoparticles (NPs) may lead to a significant cellular and humoral immune response, without compromising the SC barrier by any pretreatment, provided this nanotechnology approach is combined with some innovative adjuvantation [69][70][71]. This is another example for the potential of nanomedicine to effectively address the immune system (compare with the section 'Nanocarriers interfering with the immune system').…”

Section: Targeting Of Nanomedicines To the Intestinal Mucosa For The mentioning

confidence: 99%

Not Just for Tumor Targeting: Unmet Medical Needs and Opportunities for Nanomedicine

Lepeltier

Nuhn

Lehr

et al. 2015

Nanomedicine (Lond.)

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During the last 3 decades, nanomedicines have provided novel opportunities to improve the delivery of chemotherapeutics in cancer therapy effectively. However, many principles learnt from there have the potential to be transferred to other diseases. This perspective article, on the one hand, critically reflects the limitations of nanomedicines in tumor therapy and, on the other hand, provides alternative examples of nanomedicinal applications in immunotherapy, noninvasive drug deliveries across epithelial barriers and strategies to combat intra- and extra-cellular bacterial infections. Looking ahead, access to highly complex nanoparticular delivery vehicles given nowadays may allow further improved therapeutic concepts against several diseases in the future too.

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Inverse micellar sugar glass (IMSG) nanoparticles for transfollicular vaccination

Cited by 40 publications

References 57 publications

Diverse Applications of Nanomedicine

Diverse Applications of Nanomedicine

Solid‐in‐oil nanodispersions for transdermal drug delivery systems

Not Just for Tumor Targeting: Unmet Medical Needs and Opportunities for Nanomedicine

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