Inverse correlation between vitamin D and CRP levels in alopecia areata: A pilot study

Abstract

IntroductionAlopecia areata (AA) is an autoimmune non‐scarring hair loss. The role of micronutrients such as iron, zinc, and vitamins, especially vitamin D, on the natural hair cycle is well defined in literature. This study aims to evaluate the correlation between vitamin D and CRP levels in patients with alopecia areata.MethodsThis cross‐sectional study was performed from beginning of October 2020 until end of December 2021. Alopecia areata patients over 18 years of age gave their written consent to participate in the study. The severity of the patients' disease was assessed using the Severity of Alopecia Tool. Serum vitamin D and CRP levels were measured and CBC and LFT were also performed.ResultsThere were significant differences between the patients with the localized form of AA and its universal form in the following variables: Vitamin D levels, SALT score, WBC, ALKP, and CRP. There was also a significant inverse correlation between CRP and vitamin D levels (p < 0.0001).ConclusionVitamin D deficiency is associated with higher CRP levels, and patients with low serum vitamin D and high CRP levels are at a higher risk of developing the universalis form of AA; therefore, these patients should undergo more aggressive treatments.

C‐reactive protein as a novel biomarker for vitamin D deficiency in alopecia areata

“…The underlying reason for this intriguing observation could be attributed to the immunomodulatory properties of vitamin D, which have been shown to influence the body's immune response and inflammatory processes 34 . Several studies matched our findings 34–36 . We advocated testing CRP to evaluate disease activity and severity in AA alongside assessing and evaluating the other physical illness symptoms and signs.…”

“…34 Several studies matched our findings. [34][35][36] We advocated testing CRP to evaluate disease activity and severity in AA alongside assessing and evaluating the other physical illness symptoms and signs.…”