2016
DOI: 10.18632/aging.100960 View full text |Buy / Rent full text
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Abstract: Genetic studies using model organisms have shown that many long-lived mutants display impaired fitness, such as reduced fecundity and delayed development. However, in several wild animals, the association between longevity and fitness does not seem to be inevitable. Thus, the relationship between longevity and fitness in wild organisms remains inconclusive. Here, we determined the correlation between lifespan and fitness, developmental rate and brood size, by using 16 wild-derived C. elegans strains originated… Show more

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“…Interventions that extend lifespan are often associated with developmental and fitness trade-offs (Van Voorhies et al, 2006;Rollins et al, 2017;Lee et al, 2016;Ball et al, 1947;Thondamal et al, 2014). We found that worms treated with either of the synergistic drug combinations showed a slight delay in development and peak egg laying and an extension of reproductive span, but we detected no change in total fertility (Figures 7A-7C).…”
Section: Drug Synergy Improves Healthspan and Delays Agingmentioning
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“…Interventions that extend lifespan are often associated with developmental and fitness trade-offs (Van Voorhies et al, 2006;Rollins et al, 2017;Lee et al, 2016;Ball et al, 1947;Thondamal et al, 2014). We found that worms treated with either of the synergistic drug combinations showed a slight delay in development and peak egg laying and an extension of reproductive span, but we detected no change in total fertility (Figures 7A-7C).…”
Section: Drug Synergy Improves Healthspan and Delays Agingmentioning
“…Social isolation may increase release of stress hormones and off-target inflammatory responses (Hawkley and Cacioppo, 2003), whereas social contact could provide beneficial environmental enrichment (Donlea et al, 2014), but is likely to increase competition for reproduction, food or territory, and exposure to communicable diseases (Krause and Ruxton, 2002). Moreover, social facilitation or 'group effects' have been observed whereby insects raised in groups rather than isolation develop faster and invest more in reproduction (Grassé, 1946;Lihoreau and Rivault, 2008;Schausberger et al, 2017;Uzsák and Schal, 2013), which may have carryover effects on adult lifespan (Lee et al, 2016).…”
Section: Introductionmentioning
“…Although early fecundity does not appear to impact longevity [30], an inverse relationship between longevity and developmental rate has been reported in a study of 16 wild-derived strains. Interestingly, this examination failed to find this correlation also among individuals within a single strain [31]. Using fish, Lee and colleagues [32] were able to artificially manipulate growth rate by controlling ambient temperature early in life.…”
Section: Intraspecies Comparisons Linking Growth Rate and Longevitymentioning