Invasive zygomycosis in India: experience in a tertiary care hospital

Chakrabarti, Arunaloke; Chatterjee, Shiv Sekhar; Das, Ashim; Panda, Naresh K.; Shivaprakash, M. R.; Kaur, Apjit; Varma, Subhash; Singhi, Sunit; Bhansali, Anil; Sakhuja, Vinay

doi:10.1136/pgmj.2008.076463

Cited by 217 publications

(256 citation statements)

References 30 publications

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“…Three case series on mucormycosis have been reported from our tertiary-care centre: 129 cases over 10 years (1990)(1991)(1992)(1993)(1994)(1995)(1996)(1997)(1998)(1999), 178 cases during the subsequent five years (2000)(2001)(2002)(2003)(2004) and then 75 cases in an 18 month period during (Chakrabarti et al, 2001, 2009. Rhizopus oryzae and Apophysomyces elegans (sensu lato) were the predominant isolates in these series (Chakrabarti et al, 2001(Chakrabarti et al, , 2006(Chakrabarti et al, , 2009.…”

Section: Introductionmentioning

confidence: 96%

“…Aspergilloma, a localized infection, has been shown to consist of highly agglutinated hyphae encased in an extracellular matrix (Loussert et al, 2010;Mowat et al, 2009). A similar exopolysaccharide matrix is also produced at the surface of fungal hyphae during invasive pulmonary aspergillosis (Loussert et al, 2010 and fungal-ball formation (Chakrabarti et al, 2001(Chakrabarti et al, , 2006(Chakrabarti et al, , 2009Goodnight et al, 1993;Kirkpatrick et al, 1979;Lahiri et al, 2001;Robey et al, 2009). Mucormycosis is categorized into rhino-orbito-cerebral (ROC), pulmonary, gastrointestinal, cutaneous and disseminated types depending upon the clinical presentation and the anatomical sites involved (Chakrabarti et al, 2001(Chakrabarti et al, , 2006(Chakrabarti et al, , 2009.…”

Section: Introductionmentioning

confidence: 99%

“…A similar exopolysaccharide matrix is also produced at the surface of fungal hyphae during invasive pulmonary aspergillosis (Loussert et al, 2010 and fungal-ball formation (Chakrabarti et al, 2001(Chakrabarti et al, , 2006(Chakrabarti et al, , 2009Goodnight et al, 1993;Kirkpatrick et al, 1979;Lahiri et al, 2001;Robey et al, 2009). Mucormycosis is categorized into rhino-orbito-cerebral (ROC), pulmonary, gastrointestinal, cutaneous and disseminated types depending upon the clinical presentation and the anatomical sites involved (Chakrabarti et al, 2001(Chakrabarti et al, , 2006(Chakrabarti et al, , 2009. While the ROC type is often associated with individuals having uncontrolled diabetes and diabetic ketoacidosis, the pulmonary, gastrointestinal and cutaneous types occur in patients with haematological malignancies or neutropenia, severe malnutrition, and trauma or burns, respectively (Chakrabarti et al, 2001(Chakrabarti et al, , 2006(Chakrabarti et al, , 2009.…”

Section: Introductionmentioning

confidence: 99%

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Biofilm formation by zygomycetes: quantification, structure and matrix composition

2011

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Most studies on fungal biofilms have focused on Candida in yeasts and Aspergillus in mycelial fungi. To the authors’ knowledge, biofilm formation by zygomycetes has not been reported previously. In this study, the biofilm-forming capacity of Rhizopus oryzae, Lichtheimia corymbifera, Rhizomucor pusillus and Apophysomyces elegans was evaluated. At appropriate seeding spore densities, Rhp . oryzae (105 c.f.u. ml−1), L. corymbifera (104 c.f.u. ml−1) and Rhm. pusillus (104 c.f.u. ml−1) produced highly intertwined, adherent structures on flat-bottomed polystyrene microtitre plates after 24 h at 37 °C. The adhered fungal hyphae were encased in an extracellular matrix, as confirmed by phase-contrast and confocal microscopy. The thickness of Rhp. oryzae, L. corymbifera and Rhm. pusillus biofilms was 109.67±10.02, 242±23.07 and 197±9.0 µm (mean±sd), respectively. Biochemical characterization of the biofilm matrix indicated the presence of glucosamine, constituting 74.54–82.22 % of its dry weight, N-acetylglucosamine, glucose and proteins. Adherence and biofilm formation were not observed in A. elegans. Although A. elegans spores germinated at all three seeding densities tested (1×107, 1×106 and 1×105 c.f.u. ml−1), no significant difference was observed (P>0.05) between the A 490 of wells inoculated with A. elegans and the cut-off A 490 for biofilm detection. This study highlights the potential for biofilm formation by at least three medically important species of zygomycetes.

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Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Biofilm formation by zygomycetes: quantification, structure and matrix composition

2011

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“…An extensive review of literature by Mignogna et [12][13][14] The higher prevalence of mucormycosis in India can be related to climatic and socioeconomic conditions and also to large diabetic population. The fungi has an affinity for blood vessels which they clog hampering the blood supply to the recipient bone that secondarily gets necrosed.…”

Section: Discussionmentioning

confidence: 99%

Management of rhinomaxillary mucormycosis with Posaconazole in immunocompetent patients

Rai

Yadav

Kumar

et al. 2016

Journal of Oral Biology and Craniofacial Research

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“…Deferoxamine binds to the host iron and is presented to the microorganism as siderophores, inducing sporulation and development of zygomycosis (10,15). Pulmonary zygomycosis is seen in patients with renal failure (16). Chronic renal failure was present in 3 of the cases: 2 patients with the rhino-orbitocerebral form and 1 patient with the disseminated form, all of whom died.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of patients with zygomycosis

Kaya¹,

Çavuş²,

Turhan³

et al. 2014

Turk J Med Sci

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Conspicuous vegetation entities of pedogenic soils rich in cadmium and their diethylene triamine pentaacetic acid (DTPA)extractable Cd content (DCd) under the temperate continental and Mediterranean climatic conditions of western Anatolia were determined. Foliage of herbaceous plants and nearby soil samples was collected from 51 zinc mining areas. DCd content was found to reach 11.6%-16.2% of the total Cd content, indicating more extractability than in many other heavy metals. Growth chamber and nursery experiments were conducted with the seeds collected. Dactylis glomerata and Galium tenuissimum subsp. tenuissimum, both common in grazing lands, were found to be accumulating 23.5 mg Cd kg -1 and 22.3 mg Cd kg -1 dry matter, respectively, which are highly phytotoxic levels. Thlaspi praecox, known as a Cd-hyperaccumulating plant species, could not be successfully introduced into the Cd-rich mining soils under controlled conditions, suggesting genetic variation or inability to adapt. Volunteer species under controlled conditions included Poa bulbosa and Plantago lanceolata, both of which were potential Cd-hyperaccumulating candidates. Silene aegyptiaca and Silene vulgaris were other species commonly found around zinc mines and they were grown under controlled conditions without difficulty. However, Cd concentrations in the above-ground tissues of all species mentioned above were not over the 100 mg kg -1 dry matter threshold value for hyperaccumulating cadmium.

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Invasive zygomycosis in India: experience in a tertiary care hospital

Cited by 217 publications

References 30 publications

Biofilm formation by zygomycetes: quantification, structure and matrix composition

Biofilm formation by zygomycetes: quantification, structure and matrix composition

Management of rhinomaxillary mucormycosis with Posaconazole in immunocompetent patients

Evaluation of patients with zygomycosis

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