Invasive Spindle Cell Carcinoma of the Conjunctiva

Confronting the Unseen: A Journey Through Primary Intra-orbital Squamous Cell Carcinoma

“…It is unclear whether this variant of SCC is a more aggressive form, or if the aggressive course of the tumor will depend on the origin and site of malignancy. Most spindle SCC arises from the conjunctiva [ 13 - 14 ]. There is a large population of pluripotent stem cells in the orbital region, and it is hypothesized that the primary spindle SCC of the orbit is a culmination of malignant degeneration of the stem cells into mesenchymal and epithelial cells [ 9 ].…”

Confronting the Unseen: A Journey Through Primary Intra-orbital Squamous Cell Carcinoma

“…It is unclear whether this variant of SCC is a more aggressive form, or if the aggressive course of the tumor will depend on the origin and site of malignancy. Most spindle SCC arises from the conjunctiva [ 13 - 14 ]. There is a large population of pluripotent stem cells in the orbital region, and it is hypothesized that the primary spindle SCC of the orbit is a culmination of malignant degeneration of the stem cells into mesenchymal and epithelial cells [ 9 ].…”

Sarcomatoid Squamous Cell Carcinoma of the Conjunctiva: A Rare Entity and A Brief Review of Literature

“…Spindle cell squamous cell carcinoma is a rare and a poorly differentiated variant of squamous cell carcinoma and has been reported to occur in numerous sites like an aerodigestive tract, skin. It is also known as spindle cell carcinoma [3][4][5][6][7][8][9][10][11] . Other terms which have been used to describe the same include polypoid carcinoma, pleomorphic carcinoma, carcinosarcoma or pseudosarcoma [4] .…”

Treatment and Pathology of an Unusual Large Carcinoma of the Conjunctiva

“…Histologically most epithelial neoplasia of the ocular surface are squamous cell carcinomas. Other entities include spindle cell carcinoma, mucoepidermoid carcinoma, and basal cell carcinoma [ 6 – 9 ]. The majority of small tumors are well differentiated squamous cell carcinomas with keratinization, but poorly differentiated cancers do occur, especially in large tumors.…”

Confronting the Unseen: A Journey Through Primary Intra-orbital Squamous Cell Carcinoma

“…It is unclear whether this variant of SCC is a more aggressive form, or if the aggressive course of the tumor will depend on the origin and site of malignancy. Most spindle SCC arises from the conjunctiva [ 13 - 14 ]. There is a large population of pluripotent stem cells in the orbital region, and it is hypothesized that the primary spindle SCC of the orbit is a culmination of malignant degeneration of the stem cells into mesenchymal and epithelial cells [ 9 ].…”

Sarcomatoid Squamous Cell Carcinoma of the Conjunctiva: A Rare Entity and A Brief Review of Literature

“…Spindle cell squamous cell carcinoma is a rare and a poorly differentiated variant of squamous cell carcinoma and has been reported to occur in numerous sites like an aerodigestive tract, skin. It is also known as spindle cell carcinoma [3][4][5][6][7][8][9][10][11] . Other terms which have been used to describe the same include polypoid carcinoma, pleomorphic carcinoma, carcinosarcoma or pseudosarcoma [4] .…”

Treatment and Pathology of an Unusual Large Carcinoma of the Conjunctiva

“…Histologically most epithelial neoplasia of the ocular surface are squamous cell carcinomas. Other entities include spindle cell carcinoma, mucoepidermoid carcinoma, and basal cell carcinoma [ 6 – 9 ]. The majority of small tumors are well differentiated squamous cell carcinomas with keratinization, but poorly differentiated cancers do occur, especially in large tumors.…”

Confronting the Unseen: A Journey Through Primary Intra-orbital Squamous Cell Carcinoma

“…It is unclear whether this variant of SCC is a more aggressive form, or if the aggressive course of the tumor will depend on the origin and site of malignancy. Most spindle SCC arises from the conjunctiva [ 13 - 14 ]. There is a large population of pluripotent stem cells in the orbital region, and it is hypothesized that the primary spindle SCC of the orbit is a culmination of malignant degeneration of the stem cells into mesenchymal and epithelial cells [ 9 ].…”

Sarcomatoid Squamous Cell Carcinoma of the Conjunctiva: A Rare Entity and A Brief Review of Literature

“…Spindle cell squamous cell carcinoma is a rare and a poorly differentiated variant of squamous cell carcinoma and has been reported to occur in numerous sites like an aerodigestive tract, skin. It is also known as spindle cell carcinoma [3][4][5][6][7][8][9][10][11] . Other terms which have been used to describe the same include polypoid carcinoma, pleomorphic carcinoma, carcinosarcoma or pseudosarcoma [4] .…”

Treatment and Pathology of an Unusual Large Carcinoma of the Conjunctiva

“…Histologically most epithelial neoplasia of the ocular surface are squamous cell carcinomas. Other entities include spindle cell carcinoma, mucoepidermoid carcinoma, and basal cell carcinoma [ 6 – 9 ]. The majority of small tumors are well differentiated squamous cell carcinomas with keratinization, but poorly differentiated cancers do occur, especially in large tumors.…”