Invasive Respiratory or Vasopressor Support and/or Death as a Proposed Composite Outcome Measure for Perioperative Care Research

Mizota, Toshiyuki; Li, Dong; Takeda, Chikashi; Shiraki, Atsuko; Matsukawa, Shino; Shimizu, Satoshi; Kai, Shinichi

doi:10.1213/ane.0000000000003921

Cited by 9 publications

(8 citation statements)

References 34 publications

(44 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Vasoactive agents are widely used in the perioperative period and are administered according to blood pressure and other hemodynamic goals 33,34 . Mizota et al reported that in a retrospective cohort study of 2776 patients who underwent major abdominal surgery, postoperative invasive respiratory or vasopressor support was associated with higher hospital mortality and lower long-term survival when limiting their analysis to 30-day survivors 35 . In our study, a 30-day mortality rate was also found to be significantly higher in patients who received inotrope/vasoconstrictor drug support due to hemodynamic instability in the first 24 postoperative hours.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of perioperative parameters in patients undergoing radical cystectomy urinary diversion surgery for bladder cancer

Ergenoğlu

Ersoy

ARIBOGAN³

2022

Cukurova Medical Journal

View full text Add to dashboard Cite

Purpose: The aim of this study was to evaluate the effect of red blood cell transfusion and/or inotropic/vasopressor agent infusion during intraoperative and postoperative first 24-hour period on 30-day and one-year survival. Materials and Methods: In the final analysis, 133 patients who underwent radical cystectomy and urinary diversion surgery between November 2011 and January 2019 were included in this study. Perioperative anesthesia management early postoperative intensive care patient follow-ups were based on. Results: A statistically significant relationship was found between intraoperative red blood cell transfusion and one-year mortality rates. A statistically significant relationship was found between red blood cell transfusion in the intensive care unit and postoperative 30-day mortality rates. The relationship between vasopressor/inotrope agent infusion in intensive care unit and postoperative 30-day mortality was statistically significant. Conclusion: In radical cystectomy and urinary diversion, intraoperative red blood cell and/or inotrope/vasopressor drug administration, and red blood cell transfusion within first 24 postoperative hours in intensive care unit are associated with lower survival rates in both early and late periods. Future studies should focus on developing and implementing different strategies for perioperative blood management and maintenance of patient hemodynamics that may affect early and late outcomes.

show abstract

Section: Discussionmentioning

confidence: 99%

Evaluation of perioperative parameters in patients undergoing radical cystectomy urinary diversion surgery for bladder cancer

Ergenoğlu

Ersoy

ARIBOGAN³

2022

Cukurova Medical Journal

View full text Add to dashboard Cite

show abstract

“…We consecutively selected patients who underwent surgery under the care of anesthesiologists at Kyoto University Hospital (1121 beds). We have published several studies using the Kyoto-IMPACT database 20 , 21 . We included adult female patients aged 18 years or older who underwent gynecologic laparoscopic surgery (i.e., adnexal surgery and/or hysterectomy) at Kyoto University Hospital between January 2012 and December 2017.…”

Section: Methodsmentioning

confidence: 99%

Association between intraoperative end-tidal carbon dioxide and postoperative nausea and vomiting in gynecologic laparoscopic surgery

Dong

Takeda

Yamazaki

et al. 2022

Sci Rep

Self Cite

View full text Add to dashboard Cite

Gynecologic laparoscopic surgery has a high incidence of postoperative nausea and vomiting (PONV). Studies suggest that low intraoperative end-tidal carbon dioxide (EtCO2) is associated with an increased incidence of PONV, but the results have not been consistent among studies. This study investigated the association between intraoperative EtCO2 and PONV in patients undergoing gynecologic laparoscopic surgeries under general anesthesia. This retrospective cohort study involved patients who underwent gynecologic laparoscopic surgeries under general anesthesia at Kyoto University Hospital. We defined low EtCO2 as a mean EtCO2 of < 35 mmHg. Multivariable modified Poisson regression analysis examined the association between low EtCO2 and PONV during postoperative two days and the postoperative length of hospital stay (PLOS). Of the 739 patients, 120 (16%) had low EtCO2, and 430 (58%) developed PONV during postoperative two days. There was no substantial association between low EtCO2 and increased incidence of PONV (adjusted risk ratio: 0.96; 95% confidence interval [CI] 0.80–1.14; p = 0.658). Furthermore, there was no substantial association between low EtCO2 and prolonged PLOS (adjusted difference in PLOS: 0.13; 95% CI − 1.00 to 1.28; p = 0.816). Intraoperative low EtCO2, specifically a mean intraoperative EtCO2 below 35 mmHg, was not substantially associated with either increased incidence of PONV or prolonged PLOS.

show abstract

“…We identified eligible patients using the Kyoto University Hospital IMProve Anesthesia Care and ouTcomes (Kyoto-IMPACT) database, which is designed to identify the relationship between intraoperative respiratory and circulatory parameters and postoperative outcomes. We have previously published several papers using this database [ 10 , 11 , 12 ]. We excluded patients younger than 18 years, patients admitted to the intensive care unit postoperatively, and patients undergoing epidural anesthesia.…”

Section: Methodsmentioning

confidence: 99%

Relationship between the Use of Fentanyl-Based Intravenous Patient-Controlled Analgesia and Clinically Significant Events in Laparoscopic Gynecological Surgery: A Single-Center Retrospective Cohort Study

Hamada

Takeda

Dong

et al. 2022

JCM

Self Cite

View full text Add to dashboard Cite

Background: This study examined the relationship between the use of fentanyl-based intravenous patient-controlled analgesia (ivPCA) and the incidence of a clinically significant event (CSE), while considering both the analgesic effects and side effects in laparoscopic gynecological surgery. Methods: This study included 816 patients undergoing laparoscopic gynecological surgery under general anesthesia at Kyoto University Hospital between 2012 and 2018. The primary exposure was the use of fentanyl-based ivPCA. We defined an outcome measure—CSE—that integrates severe wound pain and vomiting assumed to negatively affect patient recovery. We performed multivariable logistic regression analysis to assess the independent relationship between ivPCA use and CSE. Results: Multivariable logistic regression analysis revealed that fentanyl-based ivPCA was independently associated with increased CSE (adjusted odds ratio (95% confidence interval): 1.80 (1.24–2.61), p = 0.002). Use of ivPCA was associated with a reduced incidence of postoperative severe wound pain (adjusted odds ratio (95% confidence interval): 0.50 (0.27–0.90), p = 0.022), but was also associated with an increased incidence of vomiting (adjusted odds ratio (95% confidence interval): 2.65 (1.79–3.92), p < 0.001). Conclusion: The use of fentanyl-based ivPCA in laparoscopic gynecological surgery is associated with increased CSE.

show abstract

Invasive Respiratory or Vasopressor Support and/or Death as a Proposed Composite Outcome Measure for Perioperative Care Research

Cited by 9 publications

References 34 publications

Evaluation of perioperative parameters in patients undergoing radical cystectomy urinary diversion surgery for bladder cancer

Evaluation of perioperative parameters in patients undergoing radical cystectomy urinary diversion surgery for bladder cancer

Association between intraoperative end-tidal carbon dioxide and postoperative nausea and vomiting in gynecologic laparoscopic surgery

Relationship between the Use of Fentanyl-Based Intravenous Patient-Controlled Analgesia and Clinically Significant Events in Laparoscopic Gynecological Surgery: A Single-Center Retrospective Cohort Study

Contact Info

Product

Resources

About