Invasive Fungal Infection in Primary Immunodeficiencies Other Than Chronic Granulomatous Disease

Garraffo, Aurélie; Pilmis, Benoît; Toubiana, Julie; Puel, Anne; Mahlaoui, Nizar; Blanche, Stéphane; Lortholary, Olivier

doi:10.1007/s12281-017-0273-x

Cited by 4 publications

(2 citation statements)

References 106 publications

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“…Other important anatomic locations are bones and eyes [70]. A subsequent case series found that CARD9deficient patients also can suffer from isolated IA in the CNS and gastrointestinal tract [71].…”

Section: Epidemiologymentioning

confidence: 99%

Epidemiology of Invasive Fungal Disease in Children

Pana

Roilides

Warris

et al. 2017

Journal of the Pediatric Infectious Diseases Society

170

138

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Considerable progress has been made in the prevention, diagnosis, and management of pediatric patients with invasive fungal disease (IFD). The reported decreasing trend in the incidence of invasive candidiasis (IC) over the past 15 years in both neonates and children has been encouraging. Nevertheless, due to the growing number of immunocompromised children at risk for IFD, this disease continues to be associated with significant morbidity and death and with increased financial burden to the health care system. Therefore, it is important to understand the contemporary epidemiology of IFD. Incidence rates of IFD in children are affected by geographical, population, and time variability. There is an ongoing effort to constantly document and update the incidence of IFD and species distribution among different pediatric populations as a means to direct preventative, diagnostic, and therapeutic resources to the most appropriate subset of patients. Children with a hematologic malignancy or a primary or secondary immunodeficiency, those undergoing solid organ or hematopoietic stem cell transplantation, and premature neonates are the major subsets of pediatric patients at risk of developing IFD. In this review, we focus on fungal disease epidemiology with a specific emphasis on the 2 most common pediatric IFDs, IC and invasive aspergillosis (IA).

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Section: Epidemiologymentioning

confidence: 99%

Epidemiology of Invasive Fungal Disease in Children

Pana

Roilides

Warris

et al. 2017

Journal of the Pediatric Infectious Diseases Society

170

138

View full text Add to dashboard Cite

show abstract

“…IFN-γ, which is produced predominantly by NK cells and T lymphocytes, promotes the production of reactive oxygen species and reactive nitrogen intermediates and enhances phagocytosis by activating macrophages [16,17]. There are plenty of case reports and case series demonstrating that the adjunctive use of IFN-γ to boost antifungal immunity can provide therapeutic benefit against invasive mycoses [18], especially in patients with congenital or acquired immunodeficiencies, including Signal Transducer and Activator of Transcription 3 (STAT3)-deficiency or HIV infection [19,20], in whom the impaired immune responses predispose to fungal infections [21]. Notwithstanding the promising results from case series and two phase II trials with the use of IFN-g treatment, either alone or in combination with standard antifungal treatment [19,22], larger randomized clinical trials are needed to further validate its beneficial effect.…”

Section: Interferon-gamma (Ifn-γ)mentioning

confidence: 99%

Reinforcing the Immunocompromised Host Defense against Fungi: Progress beyond the Current State of the Art

Karavalakis

Yannaki

Παπαδοπούλου

2021

JoF

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Despite the availability of a variety of antifungal drugs, opportunistic fungal infections still remain life-threatening for immunocompromised patients, such as those undergoing allogeneic hematopoietic cell transplantation or solid organ transplantation. Suboptimal efficacy, toxicity, development of resistant variants and recurrent episodes are limitations associated with current antifungal drug therapy. Adjunctive immunotherapies reinforcing the host defense against fungi and aiding in clearance of opportunistic pathogens are continuously gaining ground in this battle. Here, we review alternative approaches for the management of fungal infections going beyond the state of the art and placing an emphasis on fungus-specific T cell immunotherapy. Harnessing the power of T cells in the form of adoptive immunotherapy represents the strenuous protagonist of the current immunotherapeutic approaches towards combating invasive fungal infections. The progress that has been made over the last years in this field and remaining challenges as well, will be discussed.

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From Culture to Fungal Biomarkers: the Diagnostic Route of Fungal Infections in Children with Primary Immunodeficiencies

Mark¹,

McGinn

2019

Curr Fungal Infect Rep

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Invasive Fungal Infection in Primary Immunodeficiencies Other Than Chronic Granulomatous Disease

Cited by 4 publications

References 106 publications

Epidemiology of Invasive Fungal Disease in Children

Epidemiology of Invasive Fungal Disease in Children

Reinforcing the Immunocompromised Host Defense against Fungi: Progress beyond the Current State of the Art

From Culture to Fungal Biomarkers: the Diagnostic Route of Fungal Infections in Children with Primary Immunodeficiencies

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