Invasive Aspergillus Sinusitis in Pediatric Bone Marrow Transplant Patients: Evaluation and Management

The Rate and Outcome of Sinonasal Disease in Children with Primary Immunodeficiency; Tertiary Hospital Experience

“…That is why mortality in this study was related to underlying diseases rather than bacterial or fungal infection, as in AIFR. Likewise, study in adult immune compromised patients showed similar detection rate where (36%) of the patients had positive culture results [6] .The detected fungal species in our study was Aspergillus spp which is in accordance with previous studies [18,19,20]. These microorganisms are saprophytes that may be found in degraded materials, soil, and fruits, as well as in healthy people's throats, nasal cavities, and feces.…”

Surgery for pediatric invasive fungal sinonasal disease

“…12 Overall, Alternaria fungal species seem to be much less commonly documented in IFSND, especially within the pediatric literature. 1,2,13,14 However, a recent retrospective review conducted by Park et al reported a similar microbiologic composition to our study with Alternaria as one of the most commonly isolated organisms. 15 Interestingly, none of patients included in this study showed pathological evidence of mucormycosis, which has also been extensively described in prior literature.…”

“…Aspergillus species are often cited as the most common etiological agents of IFSND . Overall, Alternaria fungal species seem to be much less commonly documented in IFSND, especially within the pediatric literature . However, a recent retrospective review conducted by Park et al reported a similar microbiologic composition to our study with Alternaria as one of the most commonly isolated organisms .…”

Invasive mold infections in iatrogenically immunocompromised children: An eight‐yr review

“…Late presentation (more than six months after onset of immunocompromised state) occurred in nearly a third of cases, when the index of suspicion for fungal infection may be lower. The lung was the most common site of infection, followed by the sinuses, as has been observed in other series (11, 13, 14). This is of relevance to the investigation of patients with suspected aspergillosis: patients with normal CT scans of their sinuses and chest have a low likelihood of aspergillosis, thereby potentially influencing choice of empiric antifungal therapy.…”