Invasion of epithelial mammalian cells by Paracoccidioides brasiliensis leads to cytoskeletal rearrangement and apoptosis of the host cell

Induction of apoptosis in A549 pulmonary cells by two Paracoccidioides brasiliensis samples

“…brasiliensis (Pb) yeast cells can enter different types of cells and probably manipulate the host cell environment to benefit their own growth and survival (Mendes-Giannini et al 2004). The successive events that may occur with P. brasiliensis are fungal adhesion, translocation into the cell cytoplasm, multiplication and the induction of apoptosis.…”

“…The successive events that may occur with P. brasiliensis are fungal adhesion, translocation into the cell cytoplasm, multiplication and the induction of apoptosis. The correlation between pathogenic mechanisms in vivo could elucidate the initial steps of the infection , 2004. The death of cells with internalised P. brasiliensis yeast cells could allow the yeast to disseminate to distant sites, such as the metastatic focus.…”

“…The mechanisms of P. brasiliensis invasion into host cells, their persistence and the subsequent induction of apoptosis may explain their ability to disseminate (Mendes Giannini et al 2004). However, the apoptotic mechanisms in alveolar epithelial cells remain largely unexplored.…”

Interactions of Paracoccidioides brasiliensis with host cells: recent advances

“…Secondly, the internalization of yeast cells of P. brasiliensis by epithelial and endothelial cells has also been demonstrated [22,23]. This could be a mechanism, by which the microorganisms gain access to the bloodstream and spread to other tissues.…”

Influência do cobre no padrão de expressão de genes envolvidos na interação de Paracoccidioides brasiliensis com a matriz extracelular

“…brasiliensis é considerado um fungo intracelular facultativo, podendo aderir e invadir células epiteliais in vivo e in vitro . A endocitose deste fungo ativa os microfilamentos e microtubulos, além de induzir apoptose (MENDES-GIANNINI et al, 2004). Embora a invasão de células não fagocíticas seja de extrema importância na patogênese da doença, a descrição de adesinas, o conhecimento de genes e moléculas relacionados à adesão e invasão durante o processo infeccioso ainda é restrito GONZALEZ et al, 2005;VICENTINI et al, 2004;MENDES-GIANNINI et al, 2006;DONÓFRIO et al, 2009;NETO et al, 2009).…”