Inulin-type fructan and infusion of Artemisia vulgaris protect the liver against carbon tetrachloride-induced liver injury

Corrêa-Ferreira, Marília Locatelli; Verdan, Maria Helena; Lívero, Francislaine Aparecida dos Reis; Galuppo, Larissa Favaretto; Telles, José Ederaldo Queiroz; Stefanello, Maria Élida Alves; Acco, Alexandra; Petkowicz, Carmen Lúcia de Oliveira

doi:10.1016/j.phymed.2016.11.017

Cited by 30 publications

(13 citation statements)

References 38 publications

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“…The sectioned tissue was stained with hematoxylin-eosin (HE) for histological examination of liver injury. The degree of liver injury was evaluated using a histological scoring system introduced by Corrêa-Ferreira et al [ 35 ]. This scoring system comprises three histological features: microvesicular steatosis grade (<5%, score 0; 5–33%, score 1; 33–66%, score 2; >66%, score 3); tumefaction grade (none, score 0; few, score 1; many, score 2); inflammatory grade (slight, score 0; moderate, score 1; marked, score 2; very marked, score 3).…”

Section: Methodsmentioning

confidence: 99%

Protective Effect of Eckol against Acute Hepatic Injury Induced by Carbon Tetrachloride in Mice

Liu

Zhang

et al. 2018

Marine Drugs

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Several in vitro studies have shown the potential hepatoprotective properties of eckol, a natural phlorotannin derived from the brown alga. However, the in vivo hepatoprotective potential of eckol has not been determined. In this study, we performed an in vivo study to investigate the protective effect of eckol and its possible mechanisms on the carbon tetrachloride (CCl4)-induced acute liver injury model in mice. Results revealed that eckol pre-treatment at the dose of 0.5 and 1.0 mg/kg/day for 7 days significantly suppressed the CCl4-induced increases of alanine transaminase (ALT) and aspartate aminotransferase (AST) levels in serum and meliorated morphological liver injury. Terminal deoxynucleotidyl transferase-mediated dUTP nick end labelling (TUNEL) analysis showed that the number of positive apoptotic hepatocytes in the eckol-treated group was lower than that in the CCl4 model group. Western blotting analysis also demonstrated the enhanced expression of bcl-2 and suppressed expression of cleaved caspase-3 by eckol. The CCl4-induced oxidative stress in liver was significantly ameliorated by eckol, which was characterized by reduced malondialdehyde (MDA) formations, and enhanced superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) activities and glutathione (GSH) content. Moreover, the CCl4-induced elevations of pro-inflammatory cytokines tumor necrosis factor (TNF)-α, interleukin (IL)-1β and IL-6 were markedly suppressed in the eckol-treated group. However, eckol enhanced the level of IL-10, a potent anti-inflammatory cytokine, and recruited CD11c+ dendritic cells into the liver tissues of CCl4-treated mice. These results indicated that eckol has the protective effect on CCl4-induced acute liver injury via multiple mechanisms including anti-apoptosis, anti-oxidation, anti-inflammation and immune regulation.

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Section: Methodsmentioning

confidence: 99%

Protective Effect of Eckol against Acute Hepatic Injury Induced by Carbon Tetrachloride in Mice

Liu

Zhang

et al. 2018

Marine Drugs

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“…The immunomodulating properties of these three plants were attributed to their high fructan content [58,59,60]. Fructans were also shown to be important immunomodulatory compounds in extracts of onion ( Allium cepa ), yacon ( Smallanthus sonchifolius ), Curcuma ( Curcuma kwangsiensis ), blue agave ( Agave tequilana ), and mugwort ( Artemisia vulgaris ) [61,62,63,64,65].…”

Section: General Function Of Fructans In the Human Bodymentioning

confidence: 99%

Fructans as Immunomodulatory and Antiviral Agents: The Case of Echinacea

et al. 2019

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Throughout history, medicinal purposes of plants have been studied, documented, and acknowledged as an integral part of human healthcare systems. The development of modern medicine still relies largely on this historical knowledge of the use and preparation of plants and their extracts. Further research into the human microbiome highlights the interaction between immunomodulatory responses and plant-derived, prebiotic compounds. One such group of compounds includes the inulin-type fructans (ITFs), which may also act as signaling molecules and antioxidants. These multifunctional compounds occur in a small proportion of plants, many of which have recognized medicinal properties. Echinacea is a well-known medicinal plant and products derived from it are sold globally for its cold-and flu-preventative and general health-promoting properties. Despite the well-documented phytochemical profile of Echinacea plants and products, little research has looked into the possible role of ITFs in these products. This review aims to highlight the occurrence of ITFs in Echinacea derived formulations and the potential role they play in immunomodulation.

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“…Artemisia is a large genus with over 300 species and belongs to the family Asteraceae, many of which were found to be effective for the liver diseases, such as A. capillaris [7,8], A. scoparia [9], A. sacrorum [10], A. absinthium [11], A. vulgaris [12], A. iwayomogi [13] and A. campestris [14]. A. lavandulaefolia as a substitute of the traditional Chinese medicine A. argyi was used for the treatment of hemorrhage, menstruation-related symptoms, diarrhea, skin diseases, stomatitis, bronchitis and liver ailments in diverse cultures [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Artemlavanins A and B from Artemisia lavandulaefolia and Their Cytotoxicity Against Hepatic Stellate Cell Line LX2

Shen

Huang

Geng

et al. 2020

Nat. Prod. Bioprospect.

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Two new sesquiterpenoids, artemlavanins A ( 1 ) and B ( 3 ), together with fifteen known compounds ( 2 and 4−17 ) were isolated from the EtOH extract of Artemisia lavandulaefolia . The structures of new compounds were elucidated by extensive spectroscopic analyses (HRESIMS, 1D and 2D NMR) and ECD calculations. Compound 1 was a sesquiterpenoid lactone possessing a rearranged eudesmane skeleton; compounds 2–5 , 6–8 , 9 and 10–12 belonged to the eudesmane, guaiane, oppositane and farnesane sesquiterpenoids, respectively; compounds 13–17 were the phenyl derivatives with a 4-hydroxyacetophenone moiety. Twelve compounds ( 1–3 , 5–7 , 10–12 , 14 , 15 and 17 ) displayed cytotoxicity against hepatic stellate cell line LX2 (HSC-LX2) with IC 50 values ranging from 35.1 to 370.3 μ M. Compounds 2 , 7 , 10–12 and 17 exhibited the stronger cytotoxicity than silybin (IC 50 , 169.6 μ M) with IC 50 values of 82.1, 35.1, 95.0, 83.8, 81.6 and 90.1 μ M. Compound 7 as the most active one showed significant inhibition on the deposition of human collagen type I (Col I), human hyaluronic acid (HA) and human laminin (HL) with IC 50 values of 10.7, 24.5 and 13.3 μ M. Graphic Abstract Electronic supplementary material The online version of this article (10.1007/s13659-020-00254-0) contains supplementary material, which is available to authorized users.

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Inulin-type fructan and infusion of Artemisia vulgaris protect the liver against carbon tetrachloride-induced liver injury

Cited by 30 publications

References 38 publications

Protective Effect of Eckol against Acute Hepatic Injury Induced by Carbon Tetrachloride in Mice

Protective Effect of Eckol against Acute Hepatic Injury Induced by Carbon Tetrachloride in Mice

Fructans as Immunomodulatory and Antiviral Agents: The Case of Echinacea

Artemlavanins A and B from Artemisia lavandulaefolia and Their Cytotoxicity Against Hepatic Stellate Cell Line LX2

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