Introductory Chapter: Biopharmaceuticals

Chen, Yuan‐Chuan; Yeh, Ming–Kung

doi:10.5772/intechopen.79194

Cited by 9 publications

(7 citation statements)

References 27 publications

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“…More than 300 protein-based drugs have been approved in the US and Europe, with proteins accounting for almost a third of all drugs under development. Almost half of the market is made up of therapeutic proteins (e.g., enzymes, antibodies, vaccines, growth factors, and cytokines), followed by industrial proteins (e.g., technical enzymes) and reagents (e.g., antibodies for protein detection and purification) [ 150 , 151 , 152 ]. Advances in recombinant protein production technologies, including engineering of expression hosts, optimization of upstream culture (e.g., bioreactor design and nutritional and physical parameters), and the development of more efficient protein extraction and purification methods are important market developments [ 19 , 153 ].…”

Section: Transgenic Plants As Green Biofactories For the Production O...mentioning

confidence: 99%

Genetic Manipulation and Bioreactor Culture of Plants as a Tool for Industry and Its Applications

et al. 2022

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In recent years, there has been a considerable increase in interest in the use of transgenic plants as sources of valuable secondary metabolites or recombinant proteins. This has been facilitated by the advent of genetic engineering technology with the possibility for direct modification of the expression of genes related to the biosynthesis of biologically active compounds. A wide range of research projects have yielded a number of efficient plant systems that produce specific secondary metabolites or recombinant proteins. Furthermore, the use of bioreactors allows production to be increased to industrial scales, which can quickly and cheaply deliver large amounts of material in a short time. The resulting plant production systems can function as small factories, and many of them that are targeted at a specific operation have been patented. This review paper summarizes the key research in the last ten years regarding the use of transgenic plants as small, green biofactories for the bioreactor-based production of secondary metabolites and recombinant proteins; it simultaneously examines the production of metabolites and recombinant proteins on an industrial scale and presents the current state of available patents in the field.

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Section: Transgenic Plants As Green Biofactories For the Production O...mentioning

confidence: 99%

Genetic Manipulation and Bioreactor Culture of Plants as a Tool for Industry and Its Applications

et al. 2022

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“…The beneficial forms of biopharmaceuticals are chiefly included the recombinant protein treatment, antibody therapy, gene therapy and cell therapy. Biopharmaceuticals are gifted at disease treatment securely and efficiently by indicating biological action and perform definite functions by stand-in on the illness pathophysiology [116]. Presently, biopharmaceuticals are widely used as beneficial agents, for example, vaccines, whole blood, antigens, immunosera, hormones, enzymes, cytokines, allergenics, gene remedies, cell therapies, monoclonal antibodies and bioproducts resulting from recombinant DNA, etc.…”

Section: In Pharmacology and Pharmaceuticalsmentioning

confidence: 99%

“…Presently, biopharmaceuticals are widely used as beneficial agents, for example, vaccines, whole blood, antigens, immunosera, hormones, enzymes, cytokines, allergenics, gene remedies, cell therapies, monoclonal antibodies and bioproducts resulting from recombinant DNA, etc. [116]. As biotherapeutic protein examination using LC-MS tool is a developing zone, this distinct focus matter in the presence of advances and deliberations of application of LC-MS for characterization along with quantification of therapeutic proteins [117].…”

Section: In Pharmacology and Pharmaceuticalsmentioning

confidence: 99%

Bioengineering tools for the production of pharmaceuticals: current perspective and future outlook

2019

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The bioengineering tools have significant advantages through less time-consuming and utilized as a promising stage for the production of pharmaceutical bioproducts under the single platform. This review highlighted the advantages and current improvement in the plant, animal and microbial bioengineering tools and outlines feasible approaches by biological and process's bioengineering levels for advancing the economic feasibility of pharmaceutical's production. The critical analysis results revealed that system biology and synthetic biology along with advanced bioengineering tools like transcriptome, proteome, metabolome and nano bioengineering tools have shown a promising impact on the development of pharmaceutical's bioproducts. Tools to overcome and resolve the accompanying encounters of pharmaceutical's production that include nano bioengineering tools are also discussed. As a summary and prospect, it also gives new insight into the challenges and possible breakthrough of the development of pharmaceutical's bioproducts through bioengineering tools.

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“…The first use of a commercial product developed by recombinant DNA technology goes back to 1982. U.S. Food and Drug Administration (FDA) approved the human insulin‐based therapeutic agent Humulin ® [3,4]. After that significant first step in this area, the gene cloning and gene expression of several biological compounds such as erythropoietin, IFN‐α, recombinant clotting factors, monoclonal antibodies, and so on have led to rapid progress [3,4].…”

Section: Introductionmentioning

confidence: 99%

“…Biopharmaceuticals are biological, medical products produced from various living sources such as humans, microbial, animals, and so on by manufacturing, extraction, or semi-synthesis. They are active biomolecules with therapeutic effects produced from native biological tissues or living cells, and they can overcome challenging issues in pharmaceutical and medical applications [2,3]. Biopharmaceuticals are applied for various therapeutic purposes, and they include vaccines, recombinant DNA technology-based products, gene therapy, blood components, enzymes, monoclonal antibodies, and so on [3].…”

Section: Introductionmentioning

confidence: 99%

Recent biopharmaceutical applications of capillary electrophoresis methods on recombinant DNA technology‐based products

et al. 2021

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Recent biopharmaceutical applications of capillary electrophoresis methods on recombinant DNA technology-based productsBiopharmaceuticals (recombinant technology-based products, vaccines, whole blood and blood components, gene therapy, cells, tissues, etc.,) are described as biological medical products produced from various living sources such as human, microbial, animal, and so on by manufacturing, extraction, or semi-synthesis. They are complex molecules having high molecular weights. For their safety and efficacy, their structural, clinical, physicochemical, and chemical features must be carefully controlled, and they must be well characterized by analytical techniques before the approval of the final product. Capillary electrophoresis (CE) having versatile modes can provide valuable safety and efficacy information, such as amino acid sequence, size variants (low and high molecular weight variants), charged variants (acidic and basic impurities), aggregates, N-linked glycosylation, and O-linked glycosylation. There are numerous applications of CE in the literature. In this review, the most significant and recent studies on the analysis of recombinant DNA technology-based products using different CE modes in the last ten years have been overviewed. It was seen that the researches mostly focus on the analysis of mAbs and IgG. In addition, in recent years, researchers have started to prefer CE combined mass spectrometry (MS) techniques to provide a more detailed characterization for protein and peptide fragments.

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Introductory Chapter: Biopharmaceuticals

Cited by 9 publications

References 27 publications

Genetic Manipulation and Bioreactor Culture of Plants as a Tool for Industry and Its Applications

Genetic Manipulation and Bioreactor Culture of Plants as a Tool for Industry and Its Applications

Bioengineering tools for the production of pharmaceuticals: current perspective and future outlook

Recent biopharmaceutical applications of capillary electrophoresis methods on recombinant DNA technology‐based products

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