Introduction to Thematic Reviews on Aging and Geriatric Medicine

Pignolo, Robert J.; Nath, Karl A.

doi:10.1016/j.mayocp.2020.04.018

Cited by 4 publications

(3 citation statements)

References 15 publications

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“…24 Aging is also associated with a chronic state of increased low-grade inflammation due to an increase of pro-inflammatory cytokines. 23,25,26 Increasing age is also associated with decreased microbial diversity and an increase in facultative and obligate anaerobes in the gut. 27 This is thought to be related to physiologic changes of aging that include prolonged transit time, decreased intestinal motility, fecal retention, along with an increased use of laxatives and antibiotics, and a decrease in fiber intake.…”

Section: Distinct Disease Phenotype and Natural Historymentioning

confidence: 99%

“…These pathophysiologic alterations include cellular senescence, progenitor cell dysfunction and chronic inflammation. 23 Aging-related immunosenescence is the result of a decrease in hematopoiesis which leads to impaired innate and adaptive immune systems. The subsequent impairment in T- and B-cell responses promotes an aberrant immune response to environmental antigens, and can promote the development of IBD.…”

Section: Section I: Updates In Disease Characterization and Risk Stra...mentioning

confidence: 99%

“…24 Aging is also associated with a chronic state of increased low-grade inflammation due to an increase of pro-inflammatory cytokines. 23,25,26…”

Section: Section I: Updates In Disease Characterization and Risk Stra...mentioning

confidence: 99%

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The elderly IBD patient in the modern era: changing paradigms in risk stratification and therapeutic management

Hong

Katz

2021

Therap Adv Gastroenterol

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The incidence and prevalence of inflammatory bowel disease (IBD) is rising in the elderly population. Compared with patients with onset during their younger years, patients with elderly onset IBD have a distinct clinical presentation, disease phenotype, and natural history. Genetics contribute less to pathogenesis of disease, whereas biological changes associated with aging including immunosenescence, dysbiosis, and frailty have a greater impact on disease outcomes. With the advent of an increasingly wider array of biologic and small-molecule therapeutic options, data regarding efficacy and safety of these agents in elderly IBD patients specifically are paramount, given the unique characteristics of this population.

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