Introduction: The Origin, Current Status, and Future of Microfluidics

Lei, Kin Fong

doi:10.1002/9783527800643.ch1

Cited by 11 publications

(6 citation statements)

References 68 publications

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“…As the materials used and their applications evolved, more specific terminology was developed, and the most widely known silicone became PDMS [26,27]. Currently, PDMS is one of the most widely used materials for fabricating microfluidic devices/systems in research laboratories [28].…”

Section: Historical Perspective On Microfluidic Systemsmentioning

confidence: 99%

Microfluidic Devices for Precision Nanoparticle Production

Bezelya,

Küçüktürkmen,

Bozkır

2023

Micro

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In recent years, the field of drug delivery has seen a significant shift towards the exploration and utilization of nanoparticles (NPs) as versatile carriers for therapeutic agents. With its ability to provide exact control over NPs’ characteristics, microfluidics has emerged as a potent platform for the efficient and controlled synthesis of NPs. Microfluidic devices designed for precise fluid manipulation at the micro-scale offer a unique platform for tailoring NP properties, enabling enhanced control over NP properties such as size, morphology, and size distribution while ensuring high batch-to-batch reproducibility. Microfluidics can be used to produce liposomes, solid lipid nanoparticles, polymer-based NPs, and lipid-polymer hybrid NPs, as well as a variety of inorganic NPs such as silica, metal, metal oxide, quantum dots, and carbon-based NPs, offering precise control over composition and surface properties. Its unique precision in tailoring NP properties holds great promise for advancing NP-based drug delivery systems in both clinical and industrial settings. Although challenges with large-scale production still remain, microfluidics offers a transformative approach to NP synthesis. In this review, starting from the historical development of microfluidic systems, the materials used to create the systems, microfabrication methods, and system components will be discussed in order to provide the reader with an overview of microfluidic systems. In the following, studies on the fabrication of nanoparticles such as lipid NPs, polymeric NPs, and inorganic NPs in microfluidic devices are included.

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Section: Historical Perspective On Microfluidic Systemsmentioning

confidence: 99%

Microfluidic Devices for Precision Nanoparticle Production

Bezelya,

Küçüktürkmen,

Bozkır

2023

Micro

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“…• effective mass and heat transfer • large surface-to-volume ratio • lower costs per analysis • lower number of steps in the process • higher specificity, sensitivity, reliability of the process. 31 The advantages of microsystems allow easy process optimisation, transfer of the process to a larger scale (scale-up), combining the elements of the system in sequence and continuous processes. 32 Connecting the elements of a microsystem can be realised in parallel or in series, and with internal and external increase in the number of subunits.…”

Section: Microfluidic Systemsmentioning

confidence: 99%

Emulsification on a Microscale: Faster, Better, and More Effective

Čulo

Grgić

Jurina³

et al. 2022

Kemija U Industriji

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Emulsions are traditionally prepared with the application of high shear forces generated by the use of static mixers, homogenisers, or ultrasound. The resulting emulsions are sensitive to change of process conditions. The application of high forces and temperatures can significantly affect the constituents of the emulsions and their final stability. Microfluidic technology seems to be a very efficient alternative to classic emulsification methods. The dimensions of microdevices in combination with continuous processes offer a great advantage over classic batch emulsification processes carried out on a larger scale. The small dimensions of the microdevices allow easy transport of equipment, better control and safety of the process, and intensified mass and energy transfer. The mixing time in microdevices is reduced to a few milliseconds because the molecules in the microchannels have a short diffusion path. In this paper, an overview of emulsification processes, the advantages of use of microfluidics in emulsification, and future perspectives of microemulsification are presented.

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“…Microfluidics have been raised from different origins of microelectronics, molecular biology, and chemical analysis [2,52,53]. One of the origins of microfluidics is microelectronics where microfabrication techniques such as photolithography have been shown to be very successful in microelectronics and MEMS devices.…”

Section: Microfluidicsmentioning

confidence: 99%

Evolution of Biochip Technology: A Review from Lab-on-a-Chip to Organ-on-a-Chip

et al. 2020

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Following the advancements in microfluidics and lab-on-a-chip (LOC) technologies, a novel biomedical application for microfluidic based devices has emerged in recent years and microengineered cell culture platforms have been created. These micro-devices, known as organ-on-a-chip (OOC) platforms mimic the in vivo like microenvironment of living organs and offer more physiologically relevant in vitro models of human organs. Consequently, the concept of OOC has gained great attention from researchers in the field worldwide to offer powerful tools for biomedical researches including disease modeling, drug development, etc. This review highlights the background of biochip development. Herein, we focus on applications of LOC devices as a versatile tool for POC applications. We also review current progress in OOC platforms towards body-on-a-chip, and we provide concluding remarks and future perspectives for OOC platforms for POC applications.

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Introduction: The Origin, Current Status, and Future of Microfluidics

Cited by 11 publications

References 68 publications

Microfluidic Devices for Precision Nanoparticle Production

Microfluidic Devices for Precision Nanoparticle Production

Emulsification on a Microscale: Faster, Better, and More Effective

Evolution of Biochip Technology: A Review from Lab-on-a-Chip to Organ-on-a-Chip

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