Introducing Biomedisa as an open-source online platform for biomedical image segmentation

Lösel, Philipp; Kamp, Thomas van de; Jayme, Alejandra; Ershov, Alexey; Faragó, Tomáš; Pichler, O; Jerome, Nicholas Tan; Aadepu, Narendar; Bremer, Sabine; Chilingaryan, S.; Heethoff, Michael; Kopmann, A.; Odar, Janes; Schmelzle, Sebastian; Zubér, M. S.; Wittbrodt, Joachim; Baumbach, Tilo; Heuveline, Vincent

doi:10.1038/s41467-020-19303-w

Cited by 129 publications

(114 citation statements)

References 52 publications

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“…Technical information : 3D rendering of murine skull, mandible, and masseter muscles corresponds to PTA contrast-enhanced high-resolution microCT data taken at the Max Planck Institute for Evolutionary Anthropology (Leipzig, Germany). Skull and mandible segmented with Avizo 9.2 (Thermo Scientific™, USA); masseter muscles segmented with the Biomedical Segmentation App (Biomedisa) ( 128 ). 3D rendering of hard and soft tissues performed with DRAGONFLY 4.1 (Object Research Systems, Canada).…”

Section: Masticatory Muscles and Bones As Secretory Tissues Muscle-bmentioning

confidence: 99%

Muscle-Bone Crosstalk in the Masticatory System: From Biomechanical to Molecular Interactions

et al. 2021

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The masticatory system is a complex and highly organized group of structures, including craniofacial bones (maxillae and mandible), muscles, teeth, joints, and neurovascular elements. While the musculoskeletal structures of the head and neck are known to have a different embryonic origin, morphology, biomechanical demands, and biochemical characteristics than the trunk and limbs, their particular molecular basis and cell biology have been much less explored. In the last decade, the concept of muscle-bone crosstalk has emerged, comprising both the loads generated during muscle contraction and a biochemical component through soluble molecules. Bone cells embedded in the mineralized tissue respond to the biomechanical input by releasing molecular factors that impact the homeostasis of the attaching skeletal muscle. In the same way, muscle-derived factors act as soluble signals that modulate the remodeling process of the underlying bones. This concept of muscle-bone crosstalk at a molecular level is particularly interesting in the mandible, due to its tight anatomical relationship with one of the biggest and strongest masticatory muscles, the masseter. However, despite the close physical and physiological interaction of both tissues for proper functioning, this topic has been poorly addressed. Here we present one of the most detailed reviews of the literature to date regarding the biomechanical and biochemical interaction between muscles and bones of the masticatory system, both during development and in physiological or pathological remodeling processes. Evidence related to how masticatory function shapes the craniofacial bones is discussed, and a proposal presented that the masticatory muscles and craniofacial bones serve as secretory tissues. We furthermore discuss our current findings of myokines-release from masseter muscle in physiological conditions, during functional adaptation or pathology, and their putative role as bone-modulators in the craniofacial system. Finally, we address the physiological implications of the crosstalk between muscles and bones in the masticatory system, analyzing pathologies or clinical procedures in which the alteration of one of them affects the homeostasis of the other. Unveiling the mechanisms of muscle-bone crosstalk in the masticatory system opens broad possibilities for understanding and treating temporomandibular disorders, which severely impair the quality of life, with a high cost for diagnosis and management.

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Section: Masticatory Muscles and Bones As Secretory Tissues Muscle-bmentioning

confidence: 99%

Muscle-Bone Crosstalk in the Masticatory System: From Biomechanical to Molecular Interactions

et al. 2021

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“…Easier access to improved high-resolution microscopy (e.g. X-ray microtomography, atomic force microscopy, confocal laser scanning microscopy) allows a more detailed insight into structure and geometry of complex biological samples [8]. Consequently, scientists from all kinds of disciplines publish their findings on different cuticle properties from various body parts across a variety of insect species, tested with several mechanical setups.…”

Section: A Complex Materials Requires Complex Analysismentioning

confidence: 99%

Biomechanics of insect cuticle: an interdisciplinary experimental challenge

2021

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The cuticle exoskeleton plays a key role in facilitating the evolutionary success of insects. Since the mid of the last century, many different biomechanical properties of exoskeletons have been investigated, always utilizing the most sophisticated scientific methods available at the time. So far, information on the biomechanical properties of cuticle seems to be as diverse as the methods used to measure them. As a consequence, insect cuticle is often considered to exhibit the most complex and diverse biomechanical properties of any biological material. However, it remains unclear which role the respective measurement methods and sample treatments used in previous studies play in supporting this claim. This review provides a broad overview of examination techniques used to study biomechanical properties of insect exoskeletons and discusses their respective advantages and disadvantages in describing the properties of a complex material such as cuticle. Our meta-analysis of the present data confirms significant effects of the respective measurement methods, sample treatments and body parts on the obtained mechanical properties. Based on our findings, we highlight research gaps and point out important factors which should be taken into account in future studies on insect cuticle.

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“…The two segmentation approaches implemented in the Biomedical Image Segmentation App (Biomedisa; Lösel & Heuveline, 2016; Lösel et al, 2020) were tested for selected synthetic CT volumes. An image stack with four unsegmented slices between segmentations of the phantom stack was used for the weighted random walk approach (segmentation performed on several days in November 2019).…”

Section: Methodsmentioning

confidence: 99%

Section: Segmentation Using Biomedisamentioning

confidence: 99%

Accuracy of bone segmentation and surface generation strategies analyzed by using synthetic CT volumes

Engelkes

2020

Journal of Anatomy

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Introducing Biomedisa as an open-source online platform for biomedical image segmentation

Cited by 129 publications

References 52 publications

Muscle-Bone Crosstalk in the Masticatory System: From Biomechanical to Molecular Interactions

Muscle-Bone Crosstalk in the Masticatory System: From Biomechanical to Molecular Interactions

Biomechanics of insect cuticle: an interdisciplinary experimental challenge

Accuracy of bone segmentation and surface generation strategies analyzed by using synthetic CT volumes

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