Intrinsically disordered regions regulate RhlE RNA helicase functions in bacteria
Stéphane Hausmann,
Johan Geiser,
George Edward Allen
et al.
Abstract:RNA helicases-central enzymes in RNA metabolism- often feature intrinsically disordered regions (IDRs) that enable phase separation and complex molecular interactions. In the bacterial pathogenPseudomonas aeruginosa, the non-redundant RhlE1 and RhlE2 RNA helicases share a conserved REC catalytic core but differ in C-terminal IDRs. Here, we show how the IDR diversity defines RhlE RNA helicase specificity of function. Both IDRs facilitate RNA binding and phase separation, localizing proteins in cytoplasmic clust… Show more
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