Intrinsically defective skin barrier function in children with atopic dermatitis correlates with disease severity

The examination of biophysical skin parameters (transepidermal water loss, skin hydration and pH value) in different body regions in Polish ponies

“…An increase in the parameter indicating epidermal damage was observed in cases of atopic dermatitis in humans (Eberlein-König et al 2000, Rudolph et al 2004, Grupta et al 2008. Similar changes were also observed in dogs, where it was found, among others, that the value of the parameter increases with the severity of the changes assessed with CADESI (Hightower et al 2008, Shimada et al 2009, Cornegliani et al 2011, Marsella 2012.…”

“…condition in human medicine. In case of human patients, they are used, among others, is assessing skin dysfunction in the course of atopic dermatitis as well as in order to determine the efficiency of locally applied treatments, including those used in atopic dermatitis (Dirschka et al 2004, Rudolph and Kownatzki 2004, Aschoff et al 2008, Grupta et al 2008, Hon et al 2011. The measurement of the aforementioned parameters, mainly transepidermal water loss, has recently also attracted the attention of veterinary dermatologists.…”

“…These methods include the examination of transepidermal water loss, corneometry, as well as measuring skin pH and Correspondence to: M. Szczepanik, e-mail: kryll@poczta.onet.pl erythema intensity. The methods were at first used in human medicine (Fluhr et al 2006, Grupta et al 2008 and are now widely applied in various diseases such as topic dermatitis (Eberlein-König et al 2000, Choi et al 2003, Rudolph et al 2004, Grupta et al 2008, contact dermatitis (Laudańska 2003) and in assessing the efficiency of locally applied medicines (Biro et al 2003, Lofler et al 2003, Aschoff et al 2008. Recently, much research involving the assessment of skin biophysical parameters has been published (Dirschka et al 2005, Fluhr et al 2006, Hightower et al 2008, Oh and Oh 2009, Cornegliani et al 2011.…”

“…TEWL measures the speed of water loss by the skin, and the measurement is subsequently used to estimate the water retention ability of the skin. The method is assumed to be a sensitive indicator of skin lesion, and a growth in the parameter is associated with epidermal damage (Oh and Oh 2009, Shimada et al 2009, Grupta et al 2008, Shah et al 2005, Fluhr et al 2006, Marsella 2012, Videmont et al 2011). …”

Biophysical parameters of rats’ skin after the administration of methimazole

“…The most common methods include transepidermal water loss (TEWL), skin hydration (corneometry), and skin pH. Correct skin hydration values are known in human medicine (10,22), and they are examined thoroughly in the course of atopic dermatitis (7,12) and contact dermatitis (20). In veterinary medicine, the mentioned parameters have been examined in dogs (14,27,30,36) and cats (4,37).…”