Intrinsic Timescales Across the Basal Ganglia

Nougaret, Simon; Fascianelli, V.; Ravel, Sabrina; Genovesio, Aldo

doi:10.1101/2021.04.07.438040

Cited by 3 publications

(16 citation statements)

References 40 publications

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“…Additional studies have replicated and extended the INT hierarchy, reinforcing the idea that brain regions exhibit unique timescales in their intrinsic activity, which reflect functional specialization in terms of temporal integration (Cavanagh, Wallis, Kennerley, & Hunt, 2016;Cirillo, Fascianelli, Ferrucci, & Genovesio, 2018;Fascianelli, Tsujimoto, Marcos, & Genovesio, 2019;Murray et al, 2014;Ogawa & Komatsu, 2010;Rossi-Pool et al, 2021, Maisson et al, 2021. The concept of INT hierarchy has even been extended to subcortical regions-specifically the basal ganglia (Nougaret, Fascianelli, Ravel, & Genovesio, 2021). Moreover, a large-scale network model, based on anatomical connectivity and the strength of local recurrent connectivity, has been used to successfully reproduce the temporal hierarchy (Chaudhuri, Knoblauch, Gariel, Kennedy, & Wang, 2015).…”

Section: Introductionmentioning

confidence: 84%

Intrinsic timescales as an organizational principle of neural processing across the whole rhesus macaque brain

Manea

Zilverstand

Uğurbil

et al. 2022

eLife

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Hierarchical temporal dynamics are a fundamental computational property of the brain; however, there are no whole-brain, noninvasive investigations into timescales of neural processing in animal models. To that end, we used the spatial resolution and sensitivity of ultrahigh field fMRI performed at 10.5 Tesla to probe timescales across the whole macaque brain. We uncovered within-species consistency between timescales estimated from fMRI and electrophysiology. Crucially, we extended existing electrophysiological hierarchies to whole brain topographies. Our results validate the complementary use of hemodynamic and electrophysiological intrinsic timescales, establishing a basis for future translational work. Further, with these results in hand, we were able to show that one facet of the high-dimensional functional connectivity topography of any region in the brain is closely related to hierarchical temporal dynamics. We demonstrated that intrinsic timescales are organized along spatial gradients that closely match functional connectivity gradient topographies across the whole brain. We conclude that intrinsic timescales are a unifying organizational principle of neural processing across the whole brain.

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Section: Introductionmentioning

confidence: 84%

Intrinsic timescales as an organizational principle of neural processing across the whole rhesus macaque brain

Manea

Zilverstand

Uğurbil

et al. 2022

eLife

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show abstract

“…(E) INTs across the MPFC reported by Maisson et al (2021). (F) INTs across the basal ganglia reported by Nougaret et al (2021). The cortical areas were defined separately for each panel to match the recording sites of the data set.…”

Section: Resultsmentioning

confidence: 99%

“…Overall, we demonstrated that INTs are organized along spatial gradients that closely matched FC gradients. Nougaret et al (2021). The cortical areas were defined separately for each panel to match the recording sites of the data set.…”

Section: Int Hierarchies Are Closely Related To Fc Gradients Across the Brainmentioning

confidence: 99%

“…Additional studies have replicated and extended the INT hierarchy, reinforcing the idea that brain regions exhibit unique timescales in their intrinsic activity, which reflect functional specialization in terms of temporal integration (Cavanagh, Wallis, Kennerley, & Hunt, 2016; Cirillo, Fascianelli, Ferrucci, & Genovesio, 2018; Fascianelli, Tsujimoto, Marcos, & Genovesio, 2019; Murray et al, 2014; Ogawa & Komatsu, 2010; Rossi-Pool et al, 2021, Maisson et al, 2021). The concept of INT hierarchy has even been extended to subcortical regions—specifically the basal ganglia (Nougaret, Fascianelli, Ravel, & Genovesio, 2021). Moreover, a large-scale network model, based on anatomical connectivity and the strength of local recurrent connectivity, has been used to successfully reproduce the temporal hierarchy (Chaudhuri, Knoblauch, Gariel, Kennedy, & Wang, 2015).…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, taking advantage of the whole-brain coverage of fMRI, we are investigating INT topography. This is important since more recent work has shown that there is significant heterogeneity within regions (Cavanagh et al, 2020; Cirillo et al, 2018; Nougaret et al, 2021), while initial investigations had assigned INTs to cortical regions as a whole,…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Intrinsic timescales as an organizational principle of neural processing across the whole rhesus macaque brain

Manea

Zilverstand

Uğurbil

et al. 2021

Preprint

View full text Add to dashboard Cite

Hierarchical temporal dynamics are a fundamental computational property of the brain; however, there are no whole-brain, noninvasive investigations into timescales of neural processing in animal models. To that end, we used the spatial resolution and sensitivity of ultra-high field fMRI to probe timescales across the whole macaque brain. We uncovered within-species consistency between timescales estimated from fMRI and electrophysiology. Crucially, we were not only able to demonstrate that we can replicate existing electrophysiological hierarchies, but we extended these to whole brain topographies. Our results validate the complementary use of hemodynamic and electrophysiological intrinsic timescales, establishing a basis for future translational work. Second, with those results in hand, we were able to show that one facet of the high-dimensional FC topography of any region in the brain is closely related to hierarchical temporal dynamics. We demonstrated that intrinsic timescales are organized along spatial gradients that closely match functional connectivity gradient topographies across the whole brain. We conclude that intrinsic timescales are an unifying organizational principle of neural processing across the whole brain.

show abstract

Neuromodulation of striatal D1 cells shapes BOLD fluctuations in anatomically connected thalamic and cortical regions

Markicevic

Sturman

Bohacek

et al. 2022

Preprint

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Understanding how the brain's macroscale dynamics are shaped by underlying microscale mechanisms is a key problem in neuroscience. In animal models, we can now investigate this relationship in unprecedented detail by directly manipulating cellular-level properties while measuring the whole-brain response using resting-state fMRI. Here we focused on understanding how blood-oxygen-level-dependent (BOLD) dynamics, measured within a structurally well-defined striato-thalamo-cortical circuit, are shaped by chemogenetically exciting or inhibiting D1 medium spiny neurons (MSNs) of the right dorsomedial striatum (CPdm). We characterize changes in both the BOLD dynamics of individual cortical and subcortical brain areas, and patterns of inter-regional coupling (functional connectivity) between pairs of areas. Using a classification approach based on a large and diverse set of time-series properties, we found that CPdm neuromodulation alters BOLD dynamics within thalamic subregions that project back to dorsomedial striatum. In the cortex, the strongest changes in local dynamics were observed in unimodal regions, i.e., regions that process information from a single sensory modality, while changes in the local dynamics weakened along a putative cortical hierarchical gradient towards transmodal regions. In contrast, a decrease in functional connectivity was observed only for cortico-striatal connections after D1 excitation. Our results provide a comprehensive understanding of how targeted cellular-level manipulations affect local BOLD dynamics at the macroscale, including the role of a circuit's structural characteristics and hierarchical cortical level in shaping those dynamics. These findings contribute to ongoing attempts to understand the influence of structure-function relationships in shaping inter regional communication at subcortical and cortical levels.

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Intrinsic Timescales Across the Basal Ganglia

Cited by 3 publications

References 40 publications

Intrinsic timescales as an organizational principle of neural processing across the whole rhesus macaque brain

Intrinsic timescales as an organizational principle of neural processing across the whole rhesus macaque brain

Intrinsic timescales as an organizational principle of neural processing across the whole rhesus macaque brain

Neuromodulation of striatal D1 cells shapes BOLD fluctuations in anatomically connected thalamic and cortical regions

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