Intrinsic and extrinsic regulation of human skin melanogenesis and pigmentation

Serre, C.; Busuttil, V.; Botto, J.

doi:10.1111/ics.12466

Cited by 179 publications

(210 citation statements)

References 176 publications

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“…Tyrosinase is an enzyme that serves a key role in melanin pigment production [ 25 ]. When melanin is synthesized, it not only promotes aging of the skin, but also causes skin hyperpigmentation and dark spots.…”

Section: Resultsmentioning

confidence: 99%

Anti-Melanogenesis Activity of 6-O-Isobutyrylbritannilactone from Inula britannica on B16F10 Melanocytes and In Vivo Zebrafish Models

et al. 2020

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A potential natural melanogenesis inhibitor was discovered in the form of a sesquiterpene isolated from the flowers of Inula britannica, specifically 6-O-isobutyrylbritannilactone (IBL). We evaluated the antimelanogenesis effects of IBL on B16F10 melanocytes and zebrafish embryos. As a result, we found that 3-isobutyl-1-methylxanthine (IBMX)-induced melanin production was reduced in a dose-dependent manner in B16F10 cells by IBL. We also analyzed B16F10 cells that were and were not treated with IBMX, investigating the melanin concentration, tyrosinase activity, mRNA levels. We also studied the protein expressions of microphthalmia-associated transcription factor (MITF), tyrosinase, and tyrosinase-related proteins (TRP1, and TRP2). Furthermore, we found that melanin synthesis and tyrosinase expression were also inhibited by IBL through the modulation of the following signaling pathways: ERK, phosphoinositide 3-kinase (PI3K)/AKT, and CREB. In addition, we studied antimelanogenic activity using zebrafish embryos and found that the embryos had significantly reduced pigmentation in the IBL-treated specimens compared to the untreated controls.

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Section: Resultsmentioning

confidence: 99%

Anti-Melanogenesis Activity of 6-O-Isobutyrylbritannilactone from Inula britannica on B16F10 Melanocytes and In Vivo Zebrafish Models

et al. 2020

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“…1 The ratio of liposome composition is molar ratio. 2 The ratio of liposome composition is weight ratio highest EE (93.55%). Amnuaikit et al [12] reported that conventional liposome showed vesicle size, zeta potential and entrapment efficiency of 641.52±19.02 nm, -27.32±1.00 and 53.55±4.9%, respectively.…”

Section: Liposome Formulation and Characterizationmentioning

confidence: 99%

“…Skin pigmentation is a physiological defense against ultraviolet radiation (UVR) and it results in the production and distribution of melanin in epidermis [1,2]. UVR which has specific wavelengths can be divided into 3 types including UVA, UVB and UVC [3].…”

Section: Introductionmentioning

confidence: 99%

Phenylethyl Resorcinol Loaded in Liposomal Cream Formulation for Cosmeceutical Application

Raknam

Pinsuwan

Amnuaikit

2020

JPRI

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Phenylethyl Resorcinol (PR) is a cosmeceutical skin lightening agent and the purpose of this study was to enhance its stability by using liposomal cream formulation which increases local efficacy and safety. Liposome formulation was prepared by modified ethanol injection method, and it contained soy phosphatidyl choline (SPC), cholesterol (CHO), Tween 80 (TW80) and deoxycholic acid (DA) mixed with 2% PR. The physicochemical properties, skin permeation as well as cellular study were evaluated in order to obtain the optimized formulation. The optimized liposome formulation composed of SPC:TW80:DA (84:16:2.5) and exhibited vesicle size, polydispersity index (PDI) and zeta potential of 286.4±8.04 nm, 0.317±0.03 and -39.20±3.85 mV, respectively. Entrapment efficiency (EE) of liposome formulation was 93.55±0.05%. The vesicle was spherical in shape and showed good physicochemical stability for 4 months. The skin permeation study demonstrated that liposome with a negative charge could result in a high PR skin deposition value of 1732.76±216.24 µg/cm2 after 24 h. Cellular study showed that liposome formulation could inhibit melanin content in B16 melanoma cells and enhance cell viability in HaCaT keratinocyte cells. The optimized PR liposome was incorporated in cream and investigated physicochemical properties, stability and skin permeation. Liposomal PR cream showed a good stability and a superior result than PR cream in skin permeation parameters, as well as in tyrosinase inhibition.

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“…In normal aging, the beginning of hair graying occurs at the age of 34 ± 9.6, 43.9 ± 10.3, and 39 ± 9 in Caucasians, African Americans, and Asians, respectively. The melanocyte stem cells responsible for the production of key pigment melanin decrease with age, and this loss of melanocyte stem cells has been explained in various studies …”

Section: Review Of Literaturementioning

confidence: 99%

Therapeutics of premature hair graying: A long journey ahead

Kaur

Bala

2019

J of Cosmetic Dermatology

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Premature graying of hair has major psychosocial and socioeconomic repercussion, as it is considered as a sign of hastily progressing old age, ill health and often leads to loss of self-esteem. Hair is said to gray prematurely when it happens before the age of 20 years in Caucasians, 25 years in Asians, and 30 years in Africans. The hair color chiefly depends on melanin pigment, and fabrication of this pigment takes place in melanosomes through the process of melanogenesis. This complex biochemical pathway (melanogenesis) is further dependent on tyrosinase which acts as fuel.The normal human scalp is subjected to various factors categorized as intrinsic and extrinsic leading to graying of hair. Intrinsic factors comprise of variants responsible for changes at genetic level while extrinsic factors include air pollution, ultraviolet radiation, smoking, and nutrition. It has been proposed that direct or indirect effect of all these factors results in the generation of reactive oxygen species (ROS), thus leading to further damage. Though research has expanded in last few years in terms of microscopic, biochemical (hormonal, enzymatic), and molecular changes happening within hair follicle/shaft, still the exact mechanism leading to premature graying of hair is not well understood. Probable solutions toward this quandary are diet, herbal remedies, and temporary hair colorants. Ironically, the latter one being the most common has various side effects such as allergic reactions, inflammation, and hair loss. The aim of this paper was to review the manifestation and probable future interventions in preventing premature hair graying. K E Y W O R D S dyes, hair cycle, hair graying, herbal remedy, oxidative stress | 1207 KAUR et Al.

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Intrinsic and extrinsic regulation of human skin melanogenesis and pigmentation

Cited by 179 publications

References 176 publications

Anti-Melanogenesis Activity of 6-O-Isobutyrylbritannilactone from Inula britannica on B16F10 Melanocytes and In Vivo Zebrafish Models

Anti-Melanogenesis Activity of 6-O-Isobutyrylbritannilactone from Inula britannica on B16F10 Melanocytes and In Vivo Zebrafish Models

Phenylethyl Resorcinol Loaded in Liposomal Cream Formulation for Cosmeceutical Application

Therapeutics of premature hair graying: A long journey ahead

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