Intravitreal Toxicity of Hydroxyacyclovir (BW-B759U), a New Antiviral Agent

Intravitreal Application of Ganciclovir in Rabbits: ERG and Electron-Microscopic Findings

“…Hasel L l \ 0030-3755/96/2104 0215 SIO.00/0 li-Mail kargem« kargcr.ch l ax +4! 61 306 12 34 hup: /www.kargcr.ch the drug [5][6][7]. To date, numerous works have appeared in respect of this field of research [8][9][10].…”

Intravitreal Application of Ganciclovir in Rabbits: ERG and Electron-Microscopic Findings

“…Hasel L l \ 0030-3755/96/2104 0215 SIO.00/0 li-Mail kargem« kargcr.ch l ax +4! 61 306 12 34 hup: /www.kargcr.ch the drug [5][6][7]. To date, numerous works have appeared in respect of this field of research [8][9][10].…”

Retinal and Corneal Toxicity and Pharmacokinetic Analysis of Intraocular Injection of Ganciclovir in Rabbit Eyes

“…Pulido investigated the retina toxicity of GCV intravitreal injection in the rabbit. Intravitreal doses of 400 μ g produced no discernible ophthalmoscopic or histologic changes and no changes in electroretinography B-waves [24]. Peyman also demonstrated no evidence of retinal toxicity by clinical or light microscopic examination at different time intervals up to 14 days after intravitreal injections of liposome-encapsulated GCV (94 µ g/0.1 mL) and trifluridine (102 µ g/0.1 mL) [25].…”

Interaction of Intravitreal Combination Drugs and the Effect on the Targeted Site

“…Many antiviral therapies have been evaluated for intravitreal administration. [50][51][52][53][54][55][56][57][58][59][60][61][62][63][64][65][66][67] These include ganciclovir 2,000 μg, foscarnet 1,000-2,000 μg, Acyclovir 240 μg, trifl uorothymidine, vidarabine, or a combination of ganciclovir and foscarnet or other combinations. 67 Although the incidence of cytomegalovirus retinitis has decreased, intravitreal anticytomegalovirus Adapted from Peyman et al 68 intravitreal injection is up to 2.5 mg) 75,[82][83][84][85] have probably produced the most signifi cant advances in the treatment of agerelated macular degeneration and other neovascular-related disease.…”

Intravitreal Application of Ganciclovir in Rabbits: ERG and Electron-Microscopic Findings

“…Hasel L l \ 0030-3755/96/2104 0215 SIO.00/0 li-Mail kargem« kargcr.ch l ax +4! 61 306 12 34 hup: /www.kargcr.ch the drug [5][6][7]. To date, numerous works have appeared in respect of this field of research [8][9][10].…”

Retinal and Corneal Toxicity and Pharmacokinetic Analysis of Intraocular Injection of Ganciclovir in Rabbit Eyes

“…Pulido investigated the retina toxicity of GCV intravitreal injection in the rabbit. Intravitreal doses of 400 μ g produced no discernible ophthalmoscopic or histologic changes and no changes in electroretinography B-waves [24]. Peyman also demonstrated no evidence of retinal toxicity by clinical or light microscopic examination at different time intervals up to 14 days after intravitreal injections of liposome-encapsulated GCV (94 µ g/0.1 mL) and trifluridine (102 µ g/0.1 mL) [25].…”

Interaction of Intravitreal Combination Drugs and the Effect on the Targeted Site

“…Many antiviral therapies have been evaluated for intravitreal administration. [50][51][52][53][54][55][56][57][58][59][60][61][62][63][64][65][66][67] These include ganciclovir 2,000 μg, foscarnet 1,000-2,000 μg, Acyclovir 240 μg, trifl uorothymidine, vidarabine, or a combination of ganciclovir and foscarnet or other combinations. 67 Although the incidence of cytomegalovirus retinitis has decreased, intravitreal anticytomegalovirus Adapted from Peyman et al 68 intravitreal injection is up to 2.5 mg) 75,[82][83][84][85] have probably produced the most signifi cant advances in the treatment of agerelated macular degeneration and other neovascular-related disease.…”

Intravitreal Application of Ganciclovir in Rabbits: ERG and Electron-Microscopic Findings

“…Hasel L l \ 0030-3755/96/2104 0215 SIO.00/0 li-Mail kargem« kargcr.ch l ax +4! 61 306 12 34 hup: /www.kargcr.ch the drug [5][6][7]. To date, numerous works have appeared in respect of this field of research [8][9][10].…”

Retinal and Corneal Toxicity and Pharmacokinetic Analysis of Intraocular Injection of Ganciclovir in Rabbit Eyes

“…Pulido investigated the retina toxicity of GCV intravitreal injection in the rabbit. Intravitreal doses of 400 μ g produced no discernible ophthalmoscopic or histologic changes and no changes in electroretinography B-waves [24]. Peyman also demonstrated no evidence of retinal toxicity by clinical or light microscopic examination at different time intervals up to 14 days after intravitreal injections of liposome-encapsulated GCV (94 µ g/0.1 mL) and trifluridine (102 µ g/0.1 mL) [25].…”

Interaction of Intravitreal Combination Drugs and the Effect on the Targeted Site

“…Many antiviral therapies have been evaluated for intravitreal administration. [50][51][52][53][54][55][56][57][58][59][60][61][62][63][64][65][66][67] These include ganciclovir 2,000 μg, foscarnet 1,000-2,000 μg, Acyclovir 240 μg, trifl uorothymidine, vidarabine, or a combination of ganciclovir and foscarnet or other combinations. 67 Although the incidence of cytomegalovirus retinitis has decreased, intravitreal anticytomegalovirus Adapted from Peyman et al 68 intravitreal injection is up to 2.5 mg) 75,[82][83][84][85] have probably produced the most signifi cant advances in the treatment of agerelated macular degeneration and other neovascular-related disease.…”