Intravital microscopic evaluation of cremasteric microcirculation in experimental testicular torsion

Boybeyi, Özlem; Yazici, Ilker; Unlu, Gulhan; Aslan, Mustafa; Soyer, Tutku

doi:10.1016/j.jpurol.2013.01.005

Cited by 4 publications

(5 citation statements)

References 16 publications

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“…9 An increased leucocyte count as a result of torsion in the cremasteric muscle tissue surrounding testicular tissue has been reported in Wistar rats; this increase worsened hypoxia, reduced microperfusion and lowered the number of functional capillary vessels. 10 The current study similarly observed that the leukocyte count was significantly higher in patients with testicular torsion when compared with the control group.…”

Section: Discussionsupporting

confidence: 75%

The value of serum mean platelet volume in testicular torsion

et al. 2015

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Objective: To compare the serum mean platelet volume (MPV) in patients with testicular torsion and healthy control subjects. Methods: This retrospective study compared clinical and demographic data from patients who underwent surgery for testicular torsion and healthy controls. Testicular torsion was diagnosed with a physical examination and Doppler ultrasonography. Age, leukocyte count, platelet count and MPV were recorded for all participants. Results: A total of 50 patients with testicular torsion and 51 healthy control subjects were enrolled. There was no significant difference in age and platelet count between the two groups. Patients with testicular torsion had a significantly higher leukocyte count and MPV, compared with controls. According to receiver operating characteristic curve analysis performed for the prediction of testicular torsion, the best cut-off point for MPV was 7.7 fl (sensitivity 62%, specificity 96%), and the best cut-off point for leukocyte count was 9.5 Â 10 9 /l (sensitivity 58%, specificity 80%). Conclusions: The MPV may be useful as an ancillary test for the diagnosis of testicular torsion. Further studies are needed in order to confirm these preliminary results.

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Section: Discussionsupporting

confidence: 75%

The value of serum mean platelet volume in testicular torsion

et al. 2015

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“…6 A study in rats showed that testis torsion leads to an increased leukocyte count within the muscular tissue of the cremaster muscle, which surrounds the testicular tissue; moreover, that study showed deteriorating hypoxia, reduced microperfusion, and reduced capillary vessel function. 7…”

Section: Discussionmentioning

confidence: 99%

Predictive value of hematological parameters in testicular torsion: retrospective investigation of data from a high-volume tertiary care center

Yücel¹,

İlbey²

2018

J Int Med Res

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Objective To investigate the use of hematological parameters in the differential diagnosis of testis torsion and epididymo-orchitis, and to determine the predictive value of these parameters in the diagnosis of testis torsion. Methods This study retrospectively reviewed the medical data of patients who presented to our institute with the complaint of acute scrotal pain. Eighty-five patients who had undergone orchiectomy or surgical detorsion due to testis torsion and 72 patients with epididymo-orchitis were included in the study. The control group comprised 78 healthy males. The groups were compared with respect to age, hematological parameters, neutrophil to lymphocyte ratio (NLR), monocyte to eosinophil ratio (MER), and platelet to lymphocyte ratio (PLR). Results The monocyte count significantly differed between testis torsion and epididymo-orchitis, and was useful in the differential diagnosis. The mean neutrophil, platelet, and white blood cell counts, and the NLR, MER, and PLR values in the control group were significantly lower than those in the torsion and epididymo-orchitis groups. Conclusion The sensitivity and specificity of NLR in predicting testis torsion were as high as the sensitivity and specificity of doppler ultrasonography, suggesting the possible use of this parameter in the diagnosis of testis torsion.

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“…The cremaster muscle was prepared for intravital microscopy following methods reported previously [ 19 ]. Briefly, animals were anesthetized with pentobarbital (65 mg/kg, i.p.)…”

Section: Methodsmentioning

confidence: 99%

Insulin renders diabetic rats resistant to acute ischemic stroke by arresting nitric oxide reaction with superoxide to form peroxynitrite

et al. 2014

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BackgroundThe functions of free radicals on the effects of insulin that result in protection against cerebral ischemic insult in diabetes remain undefined. This present study aims to explain the contradiction among nitric oxide (NO)/superoxide/peroxynitrite of insulin in amelioration of focal cerebral ischemia–reperfusion (FC I/R) injury in streptozotocin (STZ)-diabetic rats and to delineate the underlying mechanisms. Long-Evans male rats were divided into three groups (age-matched controls, diabetic, and diabetic treated with insulin) with or without being subjected to FC I/R injury.ResultsHyperglycemia exacerbated microvascular functions, increased cerebral NO production, and aggravated FC I/R-induced cerebral infarction and neurological deficits. Parallel with hypoglycemic effects, insulin improved microvascular functions and attenuated FC I/R injury in STZ-diabetic rats. Diabetes decreased the efficacy of NO and superoxide production, but NO and superoxide easily formed peroxynitrite in diabetic rats after FC I/R injury. Insulin treatment significantly rescued the phenomenon.ConclusionsThese results suggest that insulin renders diabetic rats resistant to acute ischemic stroke by arresting NO reaction with superoxide to form peroxynitrite.

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Intravital microscopic evaluation of cremasteric microcirculation in experimental testicular torsion

Cited by 4 publications

References 16 publications

The value of serum mean platelet volume in testicular torsion

The value of serum mean platelet volume in testicular torsion

Predictive value of hematological parameters in testicular torsion: retrospective investigation of data from a high-volume tertiary care center

Insulin renders diabetic rats resistant to acute ischemic stroke by arresting nitric oxide reaction with superoxide to form peroxynitrite

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