Intravenous Magnesium for Prevention of Atrial Fibrillation After Coronary Artery Bypass Surgery: A Systematic Review and Meta-Analysis

Alghamdi, Abdullah A.; Al‐Radi, Osman O.; Latter, David A.

doi:10.1111/j.1540-8191.2005.200447.x

Cited by 52 publications

(32 citation statements)

References 43 publications

(47 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Again, they did not recommend one specific magnesium prophylactic regimen. Finally, the most recent meta-analysis by Alghamdi et al [85], summarized only eight randomized controlled trials that compared magnesium with placebo. They also found a highly significant reduction in relative risk with the addition of magnesium.…”

Section: Pharmacologic Prophylaxis For Postoperative Atrial Fibrillationmentioning

confidence: 99%

Pharmacologic prophylaxis for atrial fibrillation following cardiac surgery: a systematic review

Koniari

Apostolakis

Rogkakou

et al. 2010

J Cardiothorac Surg

View full text Add to dashboard Cite

Atrial Fibrillation (AF) is the most common arrhythmia occurring after cardiac surgery. Its incidence varies depending on type of surgery. Postoperative AF may cause hemodynamic deterioration, predispose to stroke and increase mortality. Effective treatment for prophylaxis of postoperative AF is vital as reduces hospitalization and overall morbidity. Beta - blockers, have been proved to prevent effectively atrial fibrillation following cardiac surgery and should be routinely used if there are no contraindications. Sotalol may be more effective than standard b-blockers for the prevention of AF without causing an excess of side effects. Amiodarone is useful when beta-blocker therapy is not possible or as additional prophylaxis in high risk patients. Other agents such as magnesium, calcium channels blocker or non-antiarrhythmic drugs as glycose-insulin - potassium, non-steroidal anti-inflammatory drugs, corticosteroids, N-acetylcysteine and statins have been studied as alternative treatment for postoperative AF prophylaxis.

show abstract

Section: Pharmacologic Prophylaxis For Postoperative Atrial Fibrillationmentioning

confidence: 99%

Pharmacologic prophylaxis for atrial fibrillation following cardiac surgery: a systematic review

Koniari

Apostolakis

Rogkakou

et al. 2010

J Cardiothorac Surg

View full text Add to dashboard Cite

show abstract

“…In a recent metaanalysis of 20 randomized trials enrolling a total of 2490 patients, magnesium supplementation reduced the frequency of AF from 28% in the control group to 18% in the treatment group, but with significant heterogeneity between trials 27 . In addition, a positive effect for intravenous magnesium administration was demonstrated in another systematic review and meta-analysis 28 . Moreover, combination therapy with magnesium and sotalol markedly reduced the occurrence of AF after cardiac surgery, when compared to either sotalol or magnesium alone 29 .…”

Section: Magnesiummentioning

confidence: 99%

Atrial fibrillation post-cardiac surgery: changing perspectives

Shantsila

Watson

Lip

2006

Current Medical Research and Opinion

View full text Add to dashboard Cite

“…A previous meta-analysis of magnesium for prevention of atrial fibrillation after CABG including eight randomized controlled trials was published in 2005 [15]. The analysis showed that intravenous magnesium is associated with a significant reduction in the incidence of atrial fibrillation after CABG, with a relative risk of 0.64 (95% confidence interval (CI) 0.47-0.87).…”

Section: Introductionmentioning

confidence: 99%

Intravenous magnesium prevents atrial fibrillation after coronary artery bypass grafting: a meta-analysis of 7 double-blind, placebo-controlled, randomized clinical trials

Wang

et al. 2012

Trials

View full text Add to dashboard Cite

BackgroundPostoperative atrial fibrillation (POAF) is the most common complication after coronary artery bypass grafting (CABG). The preventive effect of magnesium on POAF is not well known. This meta-analysis was undertaken to assess the efficacy of intravenous magnesium on the prevention of POAF after CABG.MethodsEligible studies were identified from electronic databases (Medline, Embase, and the Cochrane Library). The primary outcome measure was the incidence of POAF. The meta-analysis was performed with the fixed-effect model or random-effect model according to heterogeneity.ResultsSeven double-blind, placebo-controlled, randomized clinical trials met the inclusion criteria including 1,028 participants. The pooled results showed that intravenous magnesium reduced the incidence of POAF by 36% (RR 0.64; 95% confidence interval (CI) 0.50-0.83; P = 0.001; with no heterogeneity between trials (heterogeneity P = 0.8, I2 = 0%)).ConclusionsThis meta-analysis indicates that intravenous magnesium significantly reduces the incidence of POAF after CABG. This finding encourages the use of intravenous magnesium as an alternative to prevent POAF after CABG. But more high quality randomized clinical trials are still need to confirm the safety.

show abstract

Intravenous Magnesium for Prevention of Atrial Fibrillation After Coronary Artery Bypass Surgery: A Systematic Review and Meta-Analysis

Cited by 52 publications

References 43 publications

Pharmacologic prophylaxis for atrial fibrillation following cardiac surgery: a systematic review

Pharmacologic prophylaxis for atrial fibrillation following cardiac surgery: a systematic review

Atrial fibrillation post-cardiac surgery: changing perspectives

Intravenous magnesium prevents atrial fibrillation after coronary artery bypass grafting: a meta-analysis of 7 double-blind, placebo-controlled, randomized clinical trials

Contact Info

Product

Resources

About