Intravenous immunoglobulin for the treatment of Kawasaki disease in children

Abstract

Children fulfilling the diagnostic criteria for Kawasaki disease should be treated with IVIG (2 gm/kg single dose) within 10 days of onset of symptoms.

Development of coronary artery lesions in indolent kawasaki disease following initial spontaneous defervescence: a retrospective cohort study

“…Among our patient cohort, the CAL complication rate ≤ 30 days of illness in the dKD group was not significantly different from that of the tKD group who had received initial IVIG therapy (9.9 % vs. 7.6 %). In addition, these rates were comparable to those seen in the recent, nationwide surveys in Japan (10.0 % in 2007–2008 and 8.5 % in 2009–2010) [ 11 , 12 ], and lower than those seen in 20–40 % of the historical cohort that received aspirin alone [ 13 , 14 ]. These findings partially support the recommendations of the Japanese rather than American guidelines for KD management; the former state that IVIG therapy is not definitely indicated for spontaneously defervesced KD because of the lesser severity of the disease [ 1 , 2 ].…”

Development of coronary artery lesions in indolent kawasaki disease following initial spontaneous defervescence: a retrospective cohort study

“…Among our patient cohort, the CAL complication rate ≤ 30 days of illness in the dKD group was not significantly different from that of the tKD group who had received initial IVIG therapy (9.9 % vs. 7.6 %). In addition, these rates were comparable to those seen in the recent, nationwide surveys in Japan (10.0 % in 2007–2008 and 8.5 % in 2009–2010) [ 11 , 12 ], and lower than those seen in 20–40 % of the historical cohort that received aspirin alone [ 13 , 14 ]. These findings partially support the recommendations of the Japanese rather than American guidelines for KD management; the former state that IVIG therapy is not definitely indicated for spontaneously defervesced KD because of the lesser severity of the disease [ 1 , 2 ].…”

Coronary Artery Disease and Systemic Vasculitis: Case Report and Review

“…(Pillebout et al, 2002). Correlation with acute myocardial infarction or multivessel disease has been rarely reported (AbdelHadi et al, 1981;Lutz et al, 2009;Osman & McCreery, 2000). (Table 1) An interesting finding of the present case, is the discrepancy between absence of serious risk factors for coronary artery disease in a young patient and severity of infarction (three-vessel disease), which was also reported in two similar cases, with thrombotic thrombocytopenic purpura.…”

Predictors of Coronary Artery Aneurysms in Kawasaki Disease

“…In the pre-IVIG era, approximately 25% of children with KD had coronary artery involvement, but data from the West have shown that the incidence has reduced to 5% after widespread use of IVIG. 4 Data in our country show the incidence of coronary artery abnormality to be 5.8%. 5 However, most of the ECHOs were performed by adult cardiologists, and this could also represent regional and ethnic variations in coronary artery involvement.…”

Development of coronary artery lesions in indolent kawasaki disease following initial spontaneous defervescence: a retrospective cohort study

“…Among our patient cohort, the CAL complication rate ≤ 30 days of illness in the dKD group was not significantly different from that of the tKD group who had received initial IVIG therapy (9.9 % vs. 7.6 %). In addition, these rates were comparable to those seen in the recent, nationwide surveys in Japan (10.0 % in 2007–2008 and 8.5 % in 2009–2010) [ 11 , 12 ], and lower than those seen in 20–40 % of the historical cohort that received aspirin alone [ 13 , 14 ]. These findings partially support the recommendations of the Japanese rather than American guidelines for KD management; the former state that IVIG therapy is not definitely indicated for spontaneously defervesced KD because of the lesser severity of the disease [ 1 , 2 ].…”

Coronary Artery Disease and Systemic Vasculitis: Case Report and Review

“…(Pillebout et al, 2002). Correlation with acute myocardial infarction or multivessel disease has been rarely reported (AbdelHadi et al, 1981;Lutz et al, 2009;Osman & McCreery, 2000). (Table 1) An interesting finding of the present case, is the discrepancy between absence of serious risk factors for coronary artery disease in a young patient and severity of infarction (three-vessel disease), which was also reported in two similar cases, with thrombotic thrombocytopenic purpura.…”

Predictors of Coronary Artery Aneurysms in Kawasaki Disease

“…In the pre-IVIG era, approximately 25% of children with KD had coronary artery involvement, but data from the West have shown that the incidence has reduced to 5% after widespread use of IVIG. 4 Data in our country show the incidence of coronary artery abnormality to be 5.8%. 5 However, most of the ECHOs were performed by adult cardiologists, and this could also represent regional and ethnic variations in coronary artery involvement.…”

Development of coronary artery lesions in indolent kawasaki disease following initial spontaneous defervescence: a retrospective cohort study

“…Among our patient cohort, the CAL complication rate ≤ 30 days of illness in the dKD group was not significantly different from that of the tKD group who had received initial IVIG therapy (9.9 % vs. 7.6 %). In addition, these rates were comparable to those seen in the recent, nationwide surveys in Japan (10.0 % in 2007–2008 and 8.5 % in 2009–2010) [ 11 , 12 ], and lower than those seen in 20–40 % of the historical cohort that received aspirin alone [ 13 , 14 ]. These findings partially support the recommendations of the Japanese rather than American guidelines for KD management; the former state that IVIG therapy is not definitely indicated for spontaneously defervesced KD because of the lesser severity of the disease [ 1 , 2 ].…”

Coronary Artery Disease and Systemic Vasculitis: Case Report and Review

“…(Pillebout et al, 2002). Correlation with acute myocardial infarction or multivessel disease has been rarely reported (AbdelHadi et al, 1981;Lutz et al, 2009;Osman & McCreery, 2000). (Table 1) An interesting finding of the present case, is the discrepancy between absence of serious risk factors for coronary artery disease in a young patient and severity of infarction (three-vessel disease), which was also reported in two similar cases, with thrombotic thrombocytopenic purpura.…”

Predictors of Coronary Artery Aneurysms in Kawasaki Disease

“…In the pre-IVIG era, approximately 25% of children with KD had coronary artery involvement, but data from the West have shown that the incidence has reduced to 5% after widespread use of IVIG. 4 Data in our country show the incidence of coronary artery abnormality to be 5.8%. 5 However, most of the ECHOs were performed by adult cardiologists, and this could also represent regional and ethnic variations in coronary artery involvement.…”