Intravenous Hydrocortisone, Corticotropin and the Electroencephalogram

Electrophysiological effects of peptides derived from pro-opiomelanocortin

“…Different mechanisms for experimentally induced seizure activity and pathological human epilepsy (Schmidt and Wilder, 1968) may perhaps account for the dissimilar action of ACTH on this abnormal activity in experimental animals and in humans. Nevertheless, these and other studies (Glaser, 1953;Glaser et al, 1955) have shown that ACTH may change brain electrical activity in both humans and experimental animals by acting directly upon the brain.…”

Electrophysiological effects of peptides derived from pro-opiomelanocortin

“…Different mechanisms for experimentally induced seizure activity and pathological human epilepsy (Schmidt and Wilder, 1968) may perhaps account for the dissimilar action of ACTH on this abnormal activity in experimental animals and in humans. Nevertheless, these and other studies (Glaser, 1953;Glaser et al, 1955) have shown that ACTH may change brain electrical activity in both humans and experimental animals by acting directly upon the brain.…”

Quantitative Electroencephalographic Correlates of Steroid Administration in Man

“…Glaser et al [9], for example, found that acute intravenous administration o f hydrocor tisone resulted in an alpha shift to a slower frequency with an increase in theta and 2-3 cycles per second spike and wave activity, although Koppel et al [12] found that acute hydrocortisone administration did not alter alpha wave frequency. Hall et al [1] performed EEGs on 9 patients with steroid psychosis and found that 5 had nonspecific changes including bursts of theta wave activity and a decrease in the amplitude and frequency o f alpha waves; these changes normalized following corticosteroid with drawal.…”

“…Fur ther, many patients with Cushing's syndrome, character ized by increased circulating levels o f endogenous cortico steroids, display pathological behavioral changes [5][6][7], Many o f the earliest studies o f these phenomena sought to relate such changes to changes in brain electrophysiology [8][9][10][11], Since the late 1950s, however, few studies have reexamined this relationship, and most o f the studies that have been conducted have investigated corticosteroid effects on brain electrophysiology in medically ill patients [1], with some exceptions [12]. Such studies often share the common drawback o f being unable to differentiate true corticosteroid-induced electrophysiological effects from effects which are secondary to the underlying medi cal illnesses.…”

The effects of stress and stress hormones on human cognition: Implications for the field of brain and cognition

“…In one man, glucocorticoid therapy sometimes led to epileptic seizures and even to status epilepticus (Loewenberg, 1954;Stephen & Noad, 1951). Similarly, some EEG abnormalities were also found in patients with Cushing's disease (Glaser, Kornfeld, & Knight, 1955;Plotz, Knowlton, & Ragan, 1952). On the whole, the clinical descriptions of cases of steroid psychosis following glucocorticoid therapy were strikingly similar to the mental disturbances associated with Cushing's disease, leading to the idea that glucocorticoids might be the underlying causes of steroid psychosis.…”

Electrophysiological effects of peptides derived from pro-opiomelanocortin

“…Different mechanisms for experimentally induced seizure activity and pathological human epilepsy (Schmidt and Wilder, 1968) may perhaps account for the dissimilar action of ACTH on this abnormal activity in experimental animals and in humans. Nevertheless, these and other studies (Glaser, 1953;Glaser et al, 1955) have shown that ACTH may change brain electrical activity in both humans and experimental animals by acting directly upon the brain.…”

Quantitative Electroencephalographic Correlates of Steroid Administration in Man

“…Glaser et al [9], for example, found that acute intravenous administration o f hydrocor tisone resulted in an alpha shift to a slower frequency with an increase in theta and 2-3 cycles per second spike and wave activity, although Koppel et al [12] found that acute hydrocortisone administration did not alter alpha wave frequency. Hall et al [1] performed EEGs on 9 patients with steroid psychosis and found that 5 had nonspecific changes including bursts of theta wave activity and a decrease in the amplitude and frequency o f alpha waves; these changes normalized following corticosteroid with drawal.…”

“…Fur ther, many patients with Cushing's syndrome, character ized by increased circulating levels o f endogenous cortico steroids, display pathological behavioral changes [5][6][7], Many o f the earliest studies o f these phenomena sought to relate such changes to changes in brain electrophysiology [8][9][10][11], Since the late 1950s, however, few studies have reexamined this relationship, and most o f the studies that have been conducted have investigated corticosteroid effects on brain electrophysiology in medically ill patients [1], with some exceptions [12]. Such studies often share the common drawback o f being unable to differentiate true corticosteroid-induced electrophysiological effects from effects which are secondary to the underlying medi cal illnesses.…”

The effects of stress and stress hormones on human cognition: Implications for the field of brain and cognition

“…In one man, glucocorticoid therapy sometimes led to epileptic seizures and even to status epilepticus (Loewenberg, 1954;Stephen & Noad, 1951). Similarly, some EEG abnormalities were also found in patients with Cushing's disease (Glaser, Kornfeld, & Knight, 1955;Plotz, Knowlton, & Ragan, 1952). On the whole, the clinical descriptions of cases of steroid psychosis following glucocorticoid therapy were strikingly similar to the mental disturbances associated with Cushing's disease, leading to the idea that glucocorticoids might be the underlying causes of steroid psychosis.…”

Electrophysiological effects of peptides derived from pro-opiomelanocortin

“…Different mechanisms for experimentally induced seizure activity and pathological human epilepsy (Schmidt and Wilder, 1968) may perhaps account for the dissimilar action of ACTH on this abnormal activity in experimental animals and in humans. Nevertheless, these and other studies (Glaser, 1953;Glaser et al, 1955) have shown that ACTH may change brain electrical activity in both humans and experimental animals by acting directly upon the brain.…”

Quantitative Electroencephalographic Correlates of Steroid Administration in Man

“…Glaser et al [9], for example, found that acute intravenous administration o f hydrocor tisone resulted in an alpha shift to a slower frequency with an increase in theta and 2-3 cycles per second spike and wave activity, although Koppel et al [12] found that acute hydrocortisone administration did not alter alpha wave frequency. Hall et al [1] performed EEGs on 9 patients with steroid psychosis and found that 5 had nonspecific changes including bursts of theta wave activity and a decrease in the amplitude and frequency o f alpha waves; these changes normalized following corticosteroid with drawal.…”

“…Fur ther, many patients with Cushing's syndrome, character ized by increased circulating levels o f endogenous cortico steroids, display pathological behavioral changes [5][6][7], Many o f the earliest studies o f these phenomena sought to relate such changes to changes in brain electrophysiology [8][9][10][11], Since the late 1950s, however, few studies have reexamined this relationship, and most o f the studies that have been conducted have investigated corticosteroid effects on brain electrophysiology in medically ill patients [1], with some exceptions [12]. Such studies often share the common drawback o f being unable to differentiate true corticosteroid-induced electrophysiological effects from effects which are secondary to the underlying medi cal illnesses.…”

The effects of stress and stress hormones on human cognition: Implications for the field of brain and cognition

“…In one man, glucocorticoid therapy sometimes led to epileptic seizures and even to status epilepticus (Loewenberg, 1954;Stephen & Noad, 1951). Similarly, some EEG abnormalities were also found in patients with Cushing's disease (Glaser, Kornfeld, & Knight, 1955;Plotz, Knowlton, & Ragan, 1952). On the whole, the clinical descriptions of cases of steroid psychosis following glucocorticoid therapy were strikingly similar to the mental disturbances associated with Cushing's disease, leading to the idea that glucocorticoids might be the underlying causes of steroid psychosis.…”